Solid Tumors

• CLINICAL_TRIALS trial_result · 2025-09-18
  Clinical Trial Update: Study of SUPLEXA in Patients With Metastatic Solid Tumours and Haematologic Malignancies [Phase 1]

  Phase 1 study of SUPLEXA in patients with metastatic solid tumors and hematologic malignancies has completed with results posted.

• CLINICAL_TRIALS trial_result · 2025-09-16
  Clinical Trial Update: A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of KD033 (SAR445710) in Subjects With Metastatic or Locally Advanced Solid Tumors [Phase 1]

  Phase 1 study of KD033 (SAR445710) in metastatic or locally advanced solid tumors has been terminated; the document provides trial details i…

• CLINICAL_TRIALS trial_result · 2025-09-11
  Clinical Trial Update: 90-Day Mortality After Emergency Department Discharge in Advanced Cancer

  The trial update reports 90-day mortality outcomes for patients with cancer after discharge from the emergency department.

• CLINICAL_TRIALS trial_result · 2025-09-10
  Clinical Trial Update: A First-in-Human Dose Escalation and Expansion Study to Evaluate Intratumoral Administration of SAR441000 as Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors [Phase 1]

  First-in-human Phase 1 dose-escalation and expansion study of intratumoral SAR441000 as monotherapy and in combination with cemiplimab in pa…

• CLINICAL_TRIALS trial_result · 2025-09-08
  Clinical Trial Update: The Safety and Dosimetry Study of 177Lu-LNC1004 Injection [Phase 1]

  This clinical trial update reports safety and dosimetry findings from a Phase 1 study of the radiopharmaceutical 177Lu-LNC1004 Injection in …

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• CLINICAL_TRIALS trial_result · 2025-08-27
  Clinical Trial Update: Atezolizumab and Tiragolumab in Patients With NSCLC or Advanced Solid Tumors Having Had Prior Treatment With a PD-1 Inhibitor [Phase 2]

  Phase 2 trial evaluating atezolizumab plus tiragolumab in patients with non-small cell lung cancer or advanced solid tumors who previously r…

• CLINICAL_TRIALS trial_result · 2025-08-22
  Clinical Trial Update: Granzyme B PET Imaging Drug as a Predictor of Immunotherapy Response to Checkpoint Inhibitors [Phase 1]

  Phase 1 results for a Granzyme B PET imaging agent studied as a predictor of response to checkpoint inhibitor immunotherapy in adults with s…

• CLINICAL_TRIALS trial_result · 2025-08-22
  Clinical Trial Update: A Study of DS-1471a In Subjects With Advanced Solid Tumors [Phase 1]

  DS-1471a was evaluated in a Phase 1 study for advanced solid tumors, and the trial has been terminated.

• CLINICAL_TRIALS trial_result · 2025-08-20
  Clinical Trial Update: Study of RP-6306 With FOLFIRI in Advanced Solid Tumors [Phase 1]

  A Phase 1 trial of RP-6306 in combination with FOLFIRI for advanced solid tumors has been terminated, with results posted.

• CLINICAL_TRIALS trial_result · 2025-08-17
  Clinical Trial Update: A Study of ADRX-0706 in Select Advanced Solid Tumors [Phase 1]

  Phase 1 study of ADRX-0706 in select advanced solid tumors is active/not recruiting, evaluating the investigational agent in triple-negative…

• CLINICAL_TRIALS trial_result · 2025-08-14
  Clinical Trial Update: A Long-term Follow-up Study of Subjects Who Received CRISPR CAR T Cellular Therapies

  This document describes a long-term follow-up study involving subjects who received CRISPR-based CAR T cell therapies; the trial is currentl…

• CLINICAL_TRIALS trial_result · 2025-08-14
  Clinical Trial Update: PLAN Intervention to Enhance Engagement of Latino Cancer Patients in Advanced Care Planning [NA]

  Completed clinical trial evaluating PLAN intervention to enhance engagement of Latino cancer patients in advanced care planning; results pos…

• CLINICAL_TRIALS trial_result · 2025-08-12
  Clinical Trial Update: Assessment of Safety and Preliminary Efficacy With BAT6026 in Solid Tumour Patients [Phase 1]

  Phase 1 trial assessing safety and preliminary efficacy of BAT6026 in patients with advanced solid tumors; the study has been terminated.

• CLINICAL_TRIALS trial_result · 2025-08-12
  Clinical Trial Update: FID-007 in Treating Participants With Advanced Solid Tumors [Phase 1]

  This clinical trial update reports on the Phase 1 study of FID-007 for advanced solid tumors, with the study currently active but not recrui…

• CLINICAL_TRIALS trial_result · 2025-08-06
  Clinical Trial Update: A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma [Phase 1, Phase 2]

  Phase 1/2 study evaluating abemaciclib in combination with other anti-cancer therapies in children and young adults with solid tumors, inclu…

• CLINICAL_TRIALS trial_result · 2025-08-03
  Clinical Trial Update: A Phase 1 Study of INCMGA00012 in Patients With Advanced Solid Tumors [Phase 1]

  This document reports the completion of a Phase 1 study of INCMGA00012 in patients with Locally Advanced Solid Tumors and Metastatic Solid T…

• CLINICAL_TRIALS trial_result · 2025-08-03
  Clinical Trial Update: A Study of INCB099280 in Combination With Axitinib in Adults With Advanced Solid Tumors [Phase 1, Phase 2]

  The Phase 1/2 trial of INCB099280 in combination with axitinib in adults with advanced solid tumors was terminated.

• CLINICAL_TRIALS trial_result · 2025-07-31
  Clinical Trial Update: Acetaminophen Before Surgery Lowers Postop Pain in Pediatric Solid Tumor Patients (ERAS) [Phase 1]

  A Phase 1 trial in pediatric patients undergoing surgery for solid tumors evaluated preoperative acetaminophen as part of an Enhanced Recove…

• CLINICAL_TRIALS trial_result · 2025-07-30
  Clinical Trial Update: Gene-Modified T Cells, Vaccine Therapy, and Nivolumab in Treating Patients With Stage IV or Locally Advanced Solid Tumors Expressing NY-ESO-1 [Phase 1]

  Phase 1 trial update evaluating NY-ESO-1–targeted gene-modified T cells combined with NY-ESO-1 vaccine therapy and nivolumab in patients wit…

• CLINICAL_TRIALS trial_result · 2025-07-29
  Clinical Trial Update: TTX-030 in Combination With Immunotherapy and/or Chemotherapy in Subjects With Advanced Cancers [Phase 1]

  Phase 1 trial update for TTX-030 in combination with immunotherapy and/or chemotherapy in adults with advanced solid tumors; the study has c…

• CLINICAL_TRIALS trial_result · 2025-07-24
  Clinical Trial Update: A First-in-human Study of Multiple Doses of BB-1701 in Subjects With Locally Advanced/Metastatic HER2 Expressing Solid Tumors [Phase 1]

  The document reports the completion of a first-in-human Phase 1 study evaluating multiple doses of BB-1701 in patients with locally advanced…

• CLINICAL_TRIALS trial_result · 2025-07-24
  Clinical Trial Update: A Phase I Clinical Study for Evaluating the Safety and Efficacy of MASCT-I in Patients With Advanced Solid Tumors [Phase 1]

  Phase I clinical trial evaluating MASCT-I for safety and efficacy in patients with advanced solid tumors has been terminated.

• CLINICAL_TRIALS trial_result · 2025-07-17
  Clinical Trial Update: A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas [Phase 1]

  A Phase I clinical trial evaluating indenoisoquinolines LMP400 and LMP776 in adults with relapsed solid tumors and lymphomas has completed.

• CLINICAL_TRIALS trial_result · 2025-07-14
  Clinical Trial Update: Patient Response to Immunotherapy Using Spliceosome Mutational Markers (PRISMM)

  PRISMM evaluates immunotherapy guided by spliceosome mutational markers in patients with metastatic solid tumors carrying SF3B1, U2AF1, or S…

• CLINICAL_TRIALS trial_result · 2025-07-10
  Clinical Trial Update: Use of Individual Pharmacokinetically (PK)-Guided Sunitinib Dosing: A Feasibility Study in Patients With Advanced Solid Tumors [Phase 1]

  A Phase 1 feasibility study assessing individual pharmacokinetic-guided dosing of sunitinib in patients with advanced solid tumors.