Smallpox
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Sign up freeTop drugs studied for this disease
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FDA approval · 2021-06-04FDA Approved: TEMBEXA — Original Application (Emergent BioDefense Operations Lansing LLC)
FDA approves TEMBEXA (brincidofovir) from Emergent BioDefense Operations Lansing LLC under an original application for the prevention of sma…
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CLINICAL_TRIALS trial_result · 2021-05-27Clinical Trial Update: Freeze-Dried MVA-BN® Lot Consistency Smallpox Trial [Phase 3]
A Phase 3 trial evaluating the lot consistency of Freeze-Dried MVA-BN for smallpox has been completed, with results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-01-12Clinical Trial Update: Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally [Phase 2]
Phase 2 trial comparing lyophilized versus liquid IMVAMUNE and a lower-dose intradermal liquid form for smallpox; results posted after compl…
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CLINICAL_TRIALS trial_result · 2020-10-12Clinical Trial Update: A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects [Phase 2]
Phase II trial comparing liquid-frozen and freeze-dried IMVAMUNE (MVA-BN) smallpox vaccine formulations in vaccinia-naïve healthy subjects; …
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CLINICAL_TRIALS trial_result · 2020-04-02Clinical Trial Update: Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection [Phase 2]
Phase II randomized trial assessing safety and immunogenicity of MVA-BN Smallpox Vaccine in HIV-infected immunocompromised subjects; study c…
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CLINICAL_TRIALS trial_result · 2019-12-05Clinical Trial Update: A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000® [Phase 3]
A Phase 3 non-inferiority trial comparing MVA-BN Smallpox vaccine to ACAM2000 in vaccinia-naïve adults 18-42; study completed with results p…
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CLINICAL_TRIALS trial_result · 2019-02-18Clinical Trial Update: An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees [Phase 2]
Phase II open-label study assessing immunogenicity and safety of a single IMVAMUNE booster given two years after prior vaccination in former…
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CLINICAL_TRIALS trial_result · 2019-01-10Clinical Trial Update: A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects [Phase 2]
A Phase 2 study assessing safety and immunogenicity of one and two doses of IMVAMUNE smallpox vaccine in vaccinia-experienced adults aged 56…
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CLINICAL_TRIALS trial_result · 2019-01-10Clinical Trial Update: Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine. [Phase 2]
A Phase 2 dose-finding study evaluated immunogenicity at three dose levels of IMVAMUNE (MVA-BN) smallpox vaccine; study completed.
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CLINICAL_TRIALS trial_result · 2019-01-09Clinical Trial Update: A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy Subjects [Phase 2]
Phase 2 randomized, double-blind trial evaluating immunogenicity and safety of MVA-BN (IMVAMUNE) smallpox vaccine in healthy subjects; resul…
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CLINICAL_TRIALS trial_result · 2019-01-03Clinical Trial Update: A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve Subjects [Phase 3]
A Phase 3 trial evaluated the immunogenicity and safety of three consecutive production lots of IMVAMUNE (MVA-BN) smallpox vaccine in health…
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FDA approval · 2018-07-13FDA Approved: TPOXX — Original Application (SIGA Technologies, Inc.)
FDA granted original approval for TPOXX (tecovirimat monohydrate) from SIGA Technologies for the treatment of smallpox due to variola virus.
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CLINICAL_TRIALS trial_result · 2018-07-05Clinical Trial Update: Poly-ICLC to Prevent Respiratory Viral Infections A Safety Study [Phase 1]
Phase 1 safety study of Poly-ICLC aimed at preventing respiratory viral infections has completed, evaluating its safety in conditions includ…
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CLINICAL_TRIALS trial_result · 2017-11-28Clinical Trial Update: A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat [Phase 3]
Phase 3 clinical trial update evaluating safety, tolerability, and pharmacokinetics of tecovirimat (TPOXX) for smallpox; the study completed…
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CLINICAL_TRIALS trial_result · 2015-12-11Clinical Trial Update: Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE® [Phase 2]
Phase II trial of IMVAMUNE to assess safety and immunogenicity for smallpox has completed. Results were posted on December 11, 2015.
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CLINICAL_TRIALS research · 2015-04-07Clinical Trial Update: VHA Clinicians and Bioterror Events: Interactive Web-based Learning [NA]
Completed clinical trial evaluating an interactive web-based learning module for VA clinicians on bioterror events related to smallpox and a…
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CLINICAL_TRIALS trial_result · 2014-12-19Clinical Trial Update: Combination Study With MVA BN and Dryvax [Phase 1]
A Phase 1 trial evaluating a combination of MVA-BN and Dryvax vaccines for smallpox has completed.
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CLINICAL_TRIALS trial_result · 2014-12-05Clinical Trial Update: Expanded Dryvax Dilution Study in Previously Vaccinated Adults [Phase 2]
A Phase 2 trial update for an expanded Dryvax dilution study in adults who were previously vaccinated against smallpox; the study status is …
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CLINICAL_TRIALS trial_result · 2014-01-22Clinical Trial Update: Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination [Phase 2]
Phase 2 trial evaluated the dose safety, tolerability, and immunogenicity of a new smallpox vaccine in adults without previous smallpox vacc…
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CLINICAL_TRIALS trial_result · 2014-01-22Clinical Trial Update: Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox Vaccine [Phase 2]
Phase 2 clinical trial evaluating safety, tolerability, and immunogenicity of three dose levels of the ACAM3000 Smallpox Vaccine. The study …
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CLINICAL_TRIALS withdrawal · 2014-01-22Clinical Trial Update: Safety Study of MVA Smallpox Vaccine in Subjects With a History of Atopic Dermatitis (AD) [Phase 1]
Phase 1 safety trial of the MVA Smallpox Vaccine in people with a history of atopic dermatitis has been withdrawn.
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CLINICAL_TRIALS research · 2014-01-22Clinical Trial Update: Safety Study of MVA Smallpox Vaccine in HIV-positive Subjects Who Are Vaccinia Naive [Phase 1]
Phase 1 safety study of the Modified Vaccinia Ankara (MVA) smallpox vaccine in HIV-positive, vaccinia-naive individuals; the trial sponsored…
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CLINICAL_TRIALS trial_result · 2014-01-13Clinical Trial Update: Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults [Phase 1]
This is a Phase 1 clinical trial evaluating safety, tolerability, and immune response of the ACAM3000 Modified Vaccinia Ankara (MVA) smallpo…
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CLINICAL_TRIALS trial_result · 2013-12-06Clinical Trial Update: Safety and Efficacy of CJ Smallpox Vaccine in Healthy Volunteers [Phase 3]
The document reports the completion of a Phase 3 trial assessing safety and efficacy of the CJ Smallpox Vaccine in healthy volunteers for sm…
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CLINICAL_TRIALS trial_result · 2013-08-02Clinical Trial Update: Safety, Reactogenicity and Immunogenicity of MVA in Hematopoietic Stem Cell Transplant (HSCT) Subjects [Phase 1]
This Phase 1 trial update reports safety, reactogenicity, and immunogenicity data for the Modified Vaccinia Ankara (MVA) vaccine in hematopo…