Seizures
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2016-10-07Clinical Trial Update: Lactate Compared to Creatine Kinase as Diagnostic Marker in Generalized Epileptic Seizure
A completed clinical trial evaluated lactate as a diagnostic biomarker compared with creatine kinase for generalized epileptic seizures, inf…
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CLINICAL_TRIALS trial_result · 2016-08-16Clinical Trial Update: Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures. [Phase 3]
Phase 3 trial evaluating diazepam for management of refractory epilepsy in patients requiring intermittent medical intervention for acute re…
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CLINICAL_TRIALS safety_alert · 2016-08-10Clinical Trial Update: Drug Utilization and Safety Events Among Children Using Esomeprazole, Other Proton Pump Inhibitors or H2-receptor Antagonists
Clinical trial update describing drug utilization and safety events in children treated with esomeprazole, other proton pump inhibitors, or …
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FDA approval · 2016-06-16FDA Approved: CEREBYX — Supplemental Application (Pfizer Laboratories Div Pfizer Inc)
The FDA approved a supplemental application for Cerebyx (fosphenytoin sodium) submitted by Pfizer Laboratories Div Pfizer Inc, expanding the…
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CLINICAL_TRIALS research · 2016-06-01Clinical Trial Update: Search for Genes Influencing Childhood Absence Epilepsy (CAE) Study
Completed clinical trial investigating genetic factors influencing childhood absence epilepsy. The study aimed to identify genes associated …
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FDA approval · 2016-05-16FDA Approved: FOSPHENYTOIN — Supplemental Application (Fresenius Kabi USA, LLC)
FDA approved a supplemental application for fosphenytoin sodium from Fresenius Kabi USA, LLC under an existing ANDA.
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CLINICAL_TRIALS trial_result · 2016-03-11Clinical Trial Update: Seizure Prophylaxis in Aneurysm Repair [Phase 4]
Phase 4 trial evaluating seizure prophylaxis during intracranial aneurysm repair was terminated; results were posted in 2016.
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CLINICAL_TRIALS trial_result · 2016-01-07Clinical Trial Update: Comparative Trial of IV Lacosamide Versus Phenytoin for Seizure Management [Phase 4]
A Phase 4 trial comparing intravenous lacosamide with phenytoin for seizure management has been terminated.
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CLINICAL_TRIALS trial_result · 2015-01-06Clinical Trial Update: Pharmacokinetics and Tolerability of Rufinamide in Healthy Chinese Subjects [Phase 1]
Phase 1 study assessing pharmacokinetics and tolerability of Rufinamide in healthy Chinese subjects has completed.
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CLINICAL_TRIALS trial_result · 2014-09-08Clinical Trial Update: Dosing of Levetiracetam (Keppra) in Neonates [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating dosing of levetiracetam (Keppra) in neonates completed with results posted in 2014.
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CLINICAL_TRIALS trial_result · 2014-03-26Clinical Trial Update: Dose-Optimization, Adjunctive Treatment Study of Ezogabine/Retigabine Immediate Release in Partial-onset Seizures [Phase 4]
Phase 4 dose-optimization study of ezogabine/retigabine IR as adjunctive treatment in partial-onset seizures was terminated; results posted …
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CLINICAL_TRIALS trial_result · 2013-06-04Clinical Trial Update: Prevention of Photoparoxysmal Abnormalities by Mozart K448 [NA]
This clinical trial evaluating prevention of photoparoxysmal abnormalities by Mozart K448 in people with epilepsy and seizures was terminate…
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FDA approval · 2013-02-28FDA Approved: LEVETIRACETAM — Original Application (Camber Pharmaceuticals, Inc.)
FDA approved Camber Pharmaceuticals' original ANDA for levetiracetam oral, authorizing a generic version of the antiepileptic drug.
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CLINICAL_TRIALS trial_result · 2013-01-29Clinical Trial Update: Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy. [Phase 3]
Phase 3 clinical trial comparing the long-term effectiveness, safety, and tolerability of carisbamate to two other frequently prescribed ant…
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CLINICAL_TRIALS research · 2013-01-21Clinical Trial Update: Neuroimaging Predictors of Treatment Failure in Adult New-onset Epilepsy
This clinical trial update discusses research on neuroimaging predictors of treatment failure in adults with new-onset epilepsy. The sponsor…
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FDA approval · 2012-12-26FDA Approved: PHENYTOIN — Original Application (Rising Pharma Holdings, Inc.)
FDA approves Rising Pharma's original ANDA for phenytoin, permitting a generic version of this antiseizure drug for seizure disorders.
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CLINICAL_TRIALS research · 2012-07-27Clinical Trial Update: Study of Bedside EEG to Evaluate Brain Injury in Premature Newborns
This clinical trial registry entry describes a study using bedside EEG to evaluate brain injury and seizures in premature newborns; sponsor …
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CLINICAL_TRIALS trial_result · 2012-07-10Clinical Trial Update: Randomized Trial Comparing 3 Routes of Delivering Lorazepam to Children. [Phase 3]
A Phase 3 randomized trial comparing three routes of delivering lorazepam to children with seizures has been terminated.
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CLINICAL_TRIALS withdrawal · 2012-05-18Clinical Trial Update: Levetiracetam in Treating Patients With Seizures Caused by Brain Metastases [NA]
The clinical trial evaluating levetiracetam for seizures caused by brain metastases has been withdrawn.
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FDA approval · 2011-11-13FDA Approved: CEREBYX — Supplemental Application (Pfizer Laboratories Div Pfizer Inc)
The FDA approved a supplemental application for Cerebyx (fosphenytoin sodium) submitted by Pfizer Laboratories Div Pfizer Inc.
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CLINICAL_TRIALS trial_result · 2011-10-26Clinical Trial Update: Intranasal Midazolam Versus Rectal Diazepam for Treatment of Seizures [Phase 2]
Phase 2 trial comparing intranasal midazolam with rectal diazepam for treatment of seizures has completed with results posted in 2011.
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CLINICAL_TRIALS trial_result · 2011-07-28Clinical Trial Update: A Pilot Study of Efficacy and Tolerability of Levetiracetam Monotherapy in Subjects With Childhood Absence Epilepsy [NA]
A completed pilot study evaluated the efficacy and tolerability of levetiracetam as monotherapy in children with childhood absence epilepsy.
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CLINICAL_TRIALS trial_result · 2011-06-08Clinical Trial Update: A Study of the Efficacy and Safety of Topiramate Treatment in Patients With Epilepsy [Phase 3]
Phase 3 study assessing the efficacy and safety of Topiramate in patients with epilepsy; the trial completed.
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CLINICAL_TRIALS trial_result · 2011-06-03Clinical Trial Update: A Study of the Efficacy and Safety of Topiramate as an add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut Syndrome [Phase 3]
Phase 3 trial assessing the efficacy and safety of add-on topiramate in Lennox-Gastaut syndrome; the study status is completed.
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CLINICAL_TRIALS research · 2010-12-16Clinical Trial Update: Pharmacokinetics of Levetiracetam (Keppra) in Neonates
This clinical trial update describes the pharmacokinetics of levetiracetam (Keppra) in neonates to inform dosing for seizures/epilepsy. The …