Schizophrenia
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: An 8-week Open-label Study of an Accelerated and Slower Switching to Xanomeline/Trospium Following Atypical Antipsychotic Treatment in Participants With Schizophrenia [Phase 4]
An 8-week open-label Phase 4 study evaluating accelerated and slower switching to Xanomeline/Trospium in participants with schizophrenia who…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: An Open-Label Study to Evaluate the Efficacy and Tolerability of Xanomeline/Trospium In First Episode/Early Phase Schizophrenia Patients [Phase 4]
A Phase 4 open-label study evaluating the efficacy and tolerability of the Xanomeline/Trospium combination in patients with first-episode or…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
A Yale University trial uses PET imaging to visualize cannabinoid receptors in people with schizophrenia, cannabis use disorder, and other p…
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CLINICAL_TRIALS trial_result · 2025-04-08Clinical Trial Update: Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments(SMART-CAT) [Phase 3]
A Phase 3 SMART design trial (SMART-CAT) evaluating sequences of antipsychotic treatments for schizophrenia has completed.
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CLINICAL_TRIALS withdrawal · 2025-04-08Clinical Trial Update: A Study to Evaluate the Safety and Tolerability of Long-Acting Oral Risperidone (LYN-005) in Participants With Schizophrenia or Schizoaffective Disorder [Phase 3]
A Phase 3 trial evaluating the safety and tolerability of Lyndra's long-acting oral risperidone (LYN-005) in schizophrenia or schizoaffectiv…
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CLINICAL_TRIALS research · 2025-04-08Clinical Trial Update: Do Antipsychotic Agents Induce Supersensitivity in Humans: A Combined PET/MRI Study in Patients With Schizophrenia [NA]
This clinical trial update describes a PET/MRI study in patients with schizophrenia to investigate whether antipsychotic medications may ind…
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CLINICAL_TRIALS trial_result · 2025-04-03Clinical Trial Update: PET Imaging Study of α7 and α4β2-nAChR in Schizophrenia [Phase 1]
A Phase 1 PET imaging trial evaluating α7 and α4β2-nAChR in schizophrenia was terminated; no results are reported.
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: Study to Assess Safety and Effectiveness of Slowly Increasing Dose and Food Effect of KarXT in Participants With Schizophrenia [Phase 3]
Phase 3 trial evaluating the KarXT fixed-dose combination (xanomeline-trospium) for schizophrenia has completed.
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: Effects of Buspirone Combined With Clozapine [EARLY_Phase 1]
This update notes the completion of an early-phase Phase 1 trial evaluating the combination of buspirone with clozapine for schizophrenia.
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CLINICAL_TRIALS research · 2025-04-02Clinical Trial Update: 40 Hz Visual Stimulation as an Intervention in Schizophrenia [NA]
A clinical trial from Technical University of Munich is evaluating 40 Hz visual stimulation as an intervention for negative symptoms in schi…
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CLINICAL_TRIALS research · 2025-04-02Clinical Trial Update: Asylumseekers Experiencing Paranoid Delusions: A Virtual Reality Study
A clinical trial update describing a virtual reality intervention study for asylum seekers with schizophrenia experiencing paranoid delusion…
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CLINICAL_TRIALS trial_result · 2025-04-01Clinical Trial Update: Efficacy and Safety of Pimavanserin as Adjunctive Treatment for the Negative Symptoms of Schizophrenia [Phase 3]
A Phase 3 trial evaluating pimavanserin as an adjunctive treatment for the negative symptoms of schizophrenia has completed; results on effi…
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CLINICAL_TRIALS research · 2025-04-01Clinical Trial Update: Efficacy and Mechanisms of TUS on Cognitive Deficits in Schizophrenia: Based on the Hippocampal-Prefrontal Circuit [NA]
A not-yet-recruiting clinical trial investigates whether transcranial ultrasound can improve cognitive deficits in schizophrenia. The study …
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CLINICAL_TRIALS trial_result · 2025-03-28Clinical Trial Update: A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia [Phase 3]
Phase 3 study investigating adjunctive KarXT for inadequately controlled schizophrenia symptoms has completed.
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CLINICAL_TRIALS research · 2025-03-28Clinical Trial Update: The Effects of Non-invasive Brain Stimulation on Treatment Adherence in Schizophrenia [NA]
This clinical trial update describes ongoing research evaluating non-invasive brain stimulation to improve treatment adherence in schizophre…
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CLINICAL_TRIALS research · 2025-03-28Clinical Trial Update: Investigating the Muscarinic System in Schizophrenia Using Positron Emission Tomography
A clinical trial update describing a PET study investigating muscarinic system involvement in schizophrenia and related disorders, which is …
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CLINICAL_TRIALS research · 2025-03-28Clinical Trial Update: The Effects of Non-invasive Neuromodulation on Illness Awareness in Schizophrenia [NA]
The clinical trial evaluating non-invasive neuromodulation to improve illness awareness in schizophrenia has been terminated.
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FDA approval · 2025-03-27FDA Approved: PALIPERIDONE — Supplemental Application (Ajanta Pharma USA Inc.)
FDA approved a supplemental application for paliperidone by Ajanta Pharma USA Inc., supporting a generic version of the drug. This action re…
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Metabolic and Clinical Effect of Alpha-lipoic Acid Administration in Schizophrenic Subjects [NA]
A completed clinical trial evaluating the metabolic and cardiac effects of alpha-lipoic acid in people with schizophrenia; results were post…
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Co-Administration of Roluperidone and Olanzapine in Adult Subjects With Moderate to Severe Negative Symptoms of Schizophrenia [Phase 1]
Phase 1 study evaluating safety, tolerability, pharmacodynamics, and pharmacokinetics of co-administering roluperidone with olanzapine in ad…
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: Culturally Adapted Cognitive Behavior Therapy Based Guided Self-help Manual for Schizophrenia Spectrum Disorder [NA]
A completed clinical trial evaluating a culturally adapted cognitive behavioral therapy guided self-help manual for schizophrenia spectrum d…
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CLINICAL_TRIALS research · 2025-03-26Clinical Trial Update: Precise Intervention Technology and Application of Low Intensity TUS on Negative Symptoms of Schizophrenia [NA]
A clinical trial is evaluating low-intensity transcranial ultrasound (TUS) with precise intervention technology for negative symptoms of sch…
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CLINICAL_TRIALS research · 2025-03-26Clinical Trial Update: iTBS for Increased Appetite Induced by Antipsychotics [NA]
A clinical trial is recruiting to test intermittent theta burst stimulation (iTBS) for increasing appetite side effects induced by antipsych…
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CLINICAL_TRIALS research · 2025-03-24Clinical Trial Update: Study of Electrophysiological Markers Related to the Cognitive and Affective Processes Behind Empathic Behaviour in Schizophrenic Spectrum Disorder [NA]
A clinical trial sponsored by Centre Hospitalier Universitaire de Nice is recruiting participants to study electrophysiological markers rela…
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CLINICAL_TRIALS trial_result · 2025-03-21Clinical Trial Update: Target Engagement and Response to Oxytocin [Phase 4]
A Phase 4 trial update evaluating oxytocin for schizophrenia, focusing on target engagement and clinical response. The study status is compl…