Rheumatic Heart Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial [Phase 2]
Phase 2 clinical trial comparing intramuscular penicillin G benzathine versus oral penicillin V prophylaxis to prevent progression of latent…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Echocardiographic Screening of Pregnant Women During Antenatal Care [NA]
Clinical trial update describing echocardiographic screening of pregnant women during antenatal care, sponsored by Thomas Pilgrim, with cond…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions [NA]
This clinical trial update describes a school-based program aimed at preventing rheumatic heart disease in endemic regions and is currently …
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CLINICAL_TRIALS trial_result · 2025-12-18Clinical Trial Update: A Non-Inferiority Trial of Stopping Penicillin in Early Rheumatic Heart Disease: GOAL-Stop [Phase 3]
GOAL-Stop is a Phase 3 non-inferiority trial to determine if stopping penicillin prophylaxis in early rheumatic heart disease is not inferio…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Vitamin K Antagonist in Rheumatic Heart Disease Patients With Mechanical Heart Valves: Our Current Status
A clinical trial update describes the current status of a study evaluating a vitamin K antagonist in rheumatic heart disease patients with m…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor [Phase 1, Phase 2]
This ClinicalTrials.gov entry describes a Phase 1/2a trial to evaluate the safety and immunogenicity of the StreptInCor vaccine candidate fo…
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CLINICAL_TRIALS research · 2025-07-16Clinical Trial Update: Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice
A clinical trial update for the Korea VHD Echo Study investigating real-world surveillance of patients with aortic, mitral, and tricuspid va…
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CLINICAL_TRIALS research · 2025-07-15Clinical Trial Update: Effectiveness of Edutainment-Based Interventions in Increasing Knowledge of Rheumatic Fever and Rheumatic Heart Disease Among School-Going Children in Nepal: Study Protocol for Colors to Save Hearts Quasi-Experimental Pretest-Posttest Study [NA]
This protocol outlines a quasi-experimental study to evaluate whether edutainment-based interventions can improve knowledge about rheumatic …
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CLINICAL_TRIALS research · 2025-06-13Clinical Trial Update: Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda [NA]
This ongoing clinical trial, sponsored by Cincinnati Children's Hospital Medical Center, aims to accelerate delivery of preventive intervent…
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CLINICAL_TRIALS research · 2025-06-12Clinical Trial Update: The Clinical Influence of Developing a Sustainable Cardiac Surgery Service to Reduce the Burden of Rheumatic Heart Disease in Sub-Saharan Africa
A clinical trial update examining the impact of developing a sustainable cardiac surgery service to reduce the burden of rheumatic heart dis…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Treating Severe Mitral Valve Annular or Valvular Calcification Using Shockwave Balloon SMARTWAVE [NA]
A clinical trial is evaluating the Shockwave Balloon SMARTWAVE device for treating severe mitral annulus or valvular calcification. The stud…
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CLINICAL_TRIALS research · 2024-11-20Clinical Trial Update: Minimal Invasive Approaches For Aortic Valvular and Subvalvular Surgeries [NA]
Clinical trial update on minimally invasive approaches for aortic valvular and subvalvular surgeries in rheumatic heart disease with valvuli…
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CLINICAL_TRIALS research · 2024-09-26Clinical Trial Update: Study on Efficacy, Safety and Durability of the UniLine Prosthesis in the Treatment of Aortic and Mitral Valve Disease
A clinical trial evaluating the efficacy, safety and durability of the UniLine Prosthesis for aortic and mitral valve disease is currently r…
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CLINICAL_TRIALS trial_result · 2024-08-27Clinical Trial Update: A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post)
This clinical trial update describes a long-term follow-up study (GOAL-Post) of participants from the GOAL trial and provides extended outco…
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CLINICAL_TRIALS trial_result · 2024-08-22Clinical Trial Update: RhEumatiC Heart diseAse Genetics
Clinical trial update on genetics research related to rheumatic heart disease; the trial status is completed.
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CLINICAL_TRIALS trial_result · 2024-06-20Clinical Trial Update: Comparison of Wire Assisted Percutaneous Balloon Mitral Valvulotomy With Standard Inoue Balloon Valvulotomy [NA]
A completed clinical trial compared wire-assisted percutaneous balloon mitral valvulotomy versus the standard Inoue balloon technique for rh…
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CLINICAL_TRIALS research · 2024-06-11Clinical Trial Update: Rituximab in Patients With Acute Rheumatic Fever [Phase 2]
A Phase 2 trial evaluating rituximab for acute rheumatic fever and rheumatic heart disease in children has been suspended with no results re…
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CLINICAL_TRIALS research · 2024-06-04Clinical Trial Update: Rheumatic Heart Disease Community Streptococcal Treatment Program "RESET" [NA]
A completed clinical trial update for the Rheumatic Heart Disease Community Streptococcal Treatment Program (RESET) sponsored by Children's …
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CLINICAL_TRIALS trial_result · 2022-11-21Clinical Trial Update: Dapagliflozin Effect on Rheumatic Mitral Stenosis [Phase 3]
Phase 3 trial evaluating dapagliflozin for rheumatic mitral stenosis in patients with rheumatic heart disease and heart failure.
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CLINICAL_TRIALS trial_result · 2022-10-05Clinical Trial Update: INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority [Phase 3]
A Phase 3 completed trial comparing vitamin K antagonists, rivaroxaban, and aspirin for rheumatic heart disease in rheumatic heart disease p…
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CLINICAL_TRIALS withdrawal · 2022-07-19Clinical Trial Update: INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority [Phase 3]
Phase 3 trial investigating anticoagulants for rheumatic heart disease was withdrawn.
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CLINICAL_TRIALS trial_result · 2021-08-19Clinical Trial Update: RIvoraxaban in Mitral Stenosis [Phase 3]
Phase 3 trial update for rivaroxaban in mitral stenosis has been terminated.
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CLINICAL_TRIALS trial_result · 2021-08-16Clinical Trial Update: The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients [Phase 3]
Phase 3 trial investigating ramipril's effect on suppressing ST2 expression in patients with rheumatic mitral stenosis.
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CLINICAL_TRIALS trial_result · 2019-10-01Clinical Trial Update: Determining the Impact of Penicillin in Latent RHD: The GOAL Trial [Phase 2]
A Phase 2 clinical trial update investigating the impact of penicillin in latent rheumatic heart disease in children; current status is unkn…
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CLINICAL_TRIALS research · 2019-02-04Clinical Trial Update: Rheumatic Heart Disease Prevalence in Leon, Nicaragua
This completed clinical trial study assesses the prevalence of rheumatic heart disease in Leon, Nicaragua, in relation to Streptococcus Grou…