Respiratory Syncytial Virus Infection

• CLINICAL_TRIALS trial_result · 2022-05-27
  Clinical Trial Update: Placebo- Controlled Study to Evaluate the Safety and Immunogenicity of the RSV-F Vaccine in Elderly Adults [Phase 2]

  Phase 2 clinical trial evaluating the safety and immunogenicity of an RSV-F vaccine in elderly adults has completed.

• CLINICAL_TRIALS trial_result · 2022-05-03
  Clinical Trial Update: A Phase 2a Study to Evaluate EDP-938 in the Virus Challenge Model [Phase 2]

  Phase 2a study evaluating EDP-938 in an RSV infection virus challenge model has been completed with results posted.

• CLINICAL_TRIALS trial_result · 2022-03-23
  Clinical Trial Update: A Study to Assess the Safety, Reactogenicity and Immune Response of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3844766A) in Older Adults [Phase 1, Phase 2]

  A completed Phase 1/Phase 2 trial evaluating the safety, reactogenicity, and immune response of GSK's RSV vaccine candidate GSK3844766A in o…

• CLINICAL_TRIALS trial_result · 2022-02-25
  Clinical Trial Update: A Study to Test GlaxoSmithKline's (GSK) Respiratory Syncytial Virus RSV Candidate Vaccine's Safety and Immune Response in Japanese Older Adults [Phase 1]

  Phase 1 trial evaluating safety and immune response of GSK's RSV vaccine candidate in Japanese older adults has completed with results poste…

• CLINICAL_TRIALS trial_result · 2022-01-05
  Clinical Trial Update: MEDI-524 (Motavizumab) for the Prevention of Respiratory Sycytial Virus (RSV) Disease Among Native American Indian Infants in the Southwestern United States [Phase 3]

  Phase 3 trial of MEDI-524 (motavizumab) for RSV prevention in Native American infants completed; results posted in 2022.

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• CLINICAL_TRIALS trial_result · 2021-12-06
  Clinical Trial Update: Safety and Immunogenicity Study to Evaluate Single- or Two-Dose Regimens Of RSV F Vaccine With and Without Aluminum Phosphate or Matrix-M1™ Adjuvants In Clinically-Stable Older Adults [Phase 2]

  Phase 2 trial update evaluating single- or two-dose RSV F vaccine regimens with or without aluminum phosphate or Matrix-M1 adjuvants in clin…

• CLINICAL_TRIALS trial_result · 2021-10-04
  Clinical Trial Update: Exploratory Study to Estimate the Prophylactic Efficacy of Palivizumab in Healthy Adult Participants Inoculated With RSV [Phase 1]

  Phase 1 exploratory trial assessing prophylactic efficacy of palivizumab in healthy adults inoculated with RSV; completed with results poste…

• CLINICAL_TRIALS trial_result · 2021-08-26
  Clinical Trial Update: A Study to Evaluate the Safety and Immunogenicity of an Adjuvanted RSV Vaccine in Healthy Older Adults [Phase 2]

  Phase 2 trial evaluating safety and immunogenicity of an adjuvanted RSV vaccine in healthy older adults; trial terminated with results poste…

• CLINICAL_TRIALS trial_result · 2021-08-18
  Clinical Trial Update: A Study to Evaluate the Safety and Immunogenicity of Seasonal Influenza Vaccine and an Adenovirus Serotype 26- Based Vaccine Encoding for the Respiratory Syncytial Virus Pre-fusion F Protein (Ad26.RSV.preF), With and Without Co-administration, in Adults Aged 60 Years and Older in Stable Health [Phase 2]

  Phase 2 trial evaluating the safety and immunogenicity of seasonal influenza vaccine with and without co-administration of Ad26.RSV.preF in …

• CLINICAL_TRIALS trial_result · 2021-08-17
  Clinical Trial Update: A Study to Evaluate a Single Intramuscular Dose of Motavizumab to Treat Children With Respiratory Syncytial Virus (RSV) Illness [Phase 2]

  Phase 2 study evaluating a single intramuscular dose of motavizumab for RSV illness in young children; trial terminated with results posted …

• CLINICAL_TRIALS trial_result · 2021-07-23
  Clinical Trial Update: An Exploratory Study to Evaluate the Prophylactic Efficacy of a Single Immunization of Ad26.RSV.preF Against Respiratory Syncytial Virus Infection in a Virus Challenge Model in Healthy 18 to 50 Year-old Adults [Phase 2]

  An exploratory Phase 2 trial evaluated whether a single dose of the Ad26.RSV.preF vaccine could prophylactically prevent Respiratory Syncyti…

• CLINICAL_TRIALS trial_result · 2021-04-13
  Clinical Trial Update: Phase 2a Respiratory Syncytial Virus (RSV) Human Challenge Study of Clesrovimab (MK-1654) in Healthy Participants (MK-1654-005) [Phase 2]

  Phase 2a human challenge trial of MK-1654 (clesrovimab) in healthy participants has completed with results posted in 2021.

• CLINICAL_TRIALS trial_result · 2021-01-08
  Clinical Trial Update: Evaluating the Infectivity, Safety, and Immunogenicity of Recombinant Live-Attenuated RSV Vaccines RSV ΔNS2/Δ1313/I1314L or RSV 276 in RSV-Seronegative Infants 6 to 24 Months of Age [Phase 1]

  Phase 1 trial assessing infectivity, safety, and immunogenicity of recombinant live-attenuated RSV vaccines in RSV-seronegative infants aged…

• CLINICAL_TRIALS trial_result · 2020-04-15
  Clinical Trial Update: A Study to Evaluate Different Dose Levels of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3888550A), Based on the Vaccine Safety and the Antibodies (Body Defences) Produced Following Vaccine Administration, When Given to Healthy Non-pregnant Women [Phase 1]

  Phase 1 trial evaluating different dose levels of an investigational RSV vaccine (GSK3888550A) in healthy non-pregnant women; study complete…

• CLINICAL_TRIALS trial_result · 2019-12-24
  Clinical Trial Update: Study to Evaluate the Antiviral Activity, Clinical Outcomes, Safety, Tolerability, and Pharmacokinetics of Orally Administered Lumicitabine Regimens in Adult Participants Hospitalized With Respiratory Syncytial Virus [Phase 2]

  Phase 2 trial evaluating lumicitabine for RSV in hospitalized adults; study terminated with results posted in 2019.

• CLINICAL_TRIALS trial_result · 2019-12-05
  Clinical Trial Update: A Study to Evaluate the Antiviral Activity, Clinical Outcomes, Safety, Tolerability, and Pharmacokinetics of Orally Administered Lumicitabine (JNJ-64041575) Regimens in Hospitalized Infants and Children Aged 28 Days to 36 Months Infected With Respiratory Syncytial Virus [Phase 2]

  Phase 2 trial evaluating lumicitabine (JNJ-64041575) in hospitalized infants and children with respiratory syncytial virus; study terminated…

• CLINICAL_TRIALS trial_result · 2019-02-19
  Clinical Trial Update: A Study to Evaluate the Safety, Tolerability and Immunogenicity of Two Vaccinations of Ad26.RSV.preF One Year Apart in Adults Aged 60 Years and Older in Stable Health [Phase 1]

  Phase 1 study evaluating the safety, tolerability, and immunogenicity of two vaccinations of Ad26.RSV.preF given one year apart in adults ag…

• CLINICAL_TRIALS trial_result · 2019-02-12
  Clinical Trial Update: Drug-Drug Interaction Study Between EDP-938, Cyclosporine and Prednisone in Healthy Adult Subjects [Phase 1]

  Phase 1 study assessed potential drug-drug interactions when co-administering EDP-938 with cyclosporine and prednisone in healthy adult subj…

• CLINICAL_TRIALS trial_result · 2019-01-10
  Clinical Trial Update: A Multicentre Study in Otherwise Healthy Infants and Toddlers Hospitalised For and Diagnosed With RSV Lower Respiratory Tract Infection to Evaluate the Safety, Tolerability, and Clinical Activity of ALX-0171 [Phase 1, Phase 2]

  Phase 1/2 multicenter trial assessing safety, tolerability, and clinical activity of ALX-0171 in otherwise healthy infants and toddlers hosp…

• CLINICAL_TRIALS trial_result · 2018-11-06
  Clinical Trial Update: Study to Evaluate the Efficacy and Safety of Suptavumab (REGN2222) for the Prevention of Medically Attended RSV (Respiratory Syncytial Virus) Infection in Preterm Infants [Phase 3]

  Phase 3 trial assessing the efficacy and safety of Suptavumab (REGN2222) for preventing medically attended RSV infections in preterm infants…

• CLINICAL_TRIALS trial_result · 2018-10-29
  Clinical Trial Update: Prospective Study for the Use of Palivizumab (Synagis®) in High-risk Children in Germany

  A completed prospective trial assessing palivizumab (Synagis) in high-risk children in Germany with results posted in 2018.

• CLINICAL_TRIALS trial_result · 2018-08-27
  Clinical Trial Update: Evaluating the Infectivity, Safety and Immunogenicity of a Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccine in RSV-Seronegative Infants 6 to 24 Months of Age [Phase 1]

  Phase 1 trial assessing infectivity, safety, and immunogenicity of a recombinant live-attenuated RSV vaccine in RSV-seronegative infants age…

• CLINICAL_TRIALS trial_result · 2018-08-13
  Clinical Trial Update: A Study to Evaluate the Safety and Ability of the Vaccine to Induce Antibodies Against the Respiratory Syncytial Virus in Healthy Adults [Phase 1]

  A Phase 1 study assessing safety and antibody-inducing potential of an RSV vaccine in healthy adults; results have been posted.

• CLINICAL_TRIALS trial_result · 2018-07-13
  Clinical Trial Update: ALX-0171 Safety Study in Adults With Hyperresponsive Airways [Phase 1]

  Phase 1 safety study of ALX-0171 in adults with hyperresponsive airways infected with respiratory syncytial virus, conducted by Ablynx (a Sa…

• CLINICAL_TRIALS trial_result · 2018-07-13
  Clinical Trial Update: ALX-0171 Phase I Study, Evaluating Single Ascending Dose and Multiple Dose in Healthy Male Volunteers [Phase 1]

  This Phase I trial evaluated single ascending dose and multiple dose regimens of ALX-0171 in healthy male volunteers and has completed.