Pulmonary Tuberculosis
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: Novel Triple-dose Tuberculosis Retreatment Regimen [Phase 3]
A Phase 3 clinical trial evaluating a novel triple-dose retreatment regimen for multidrug-resistant and pulmonary tuberculosis is currently …
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CLINICAL_TRIALS trial_result · 2025-04-10Clinical Trial Update: Safety and Efficacy Evaluation of 4-month Regimen of OPC-167832, Delamanid and Bedaquiline in Participants With Drug-Susceptible Pulmonary TB [Phase 2]
Phase 2 trial evaluating the safety and efficacy of a 4-month regimen combining OPC-167832, delamanid, and bedaquiline for drug-susceptible …
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Pulmonary Aspergillosis in Tuberculosis Patients
A clinical trial update shows an active-not-recruiting study on pulmonary aspergillosis in patients with tuberculosis, examining overlap bet…
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CLINICAL_TRIALS research · 2025-04-01Clinical Trial Update: Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis:Contezolid, Delamanid and Bedaquiline Cohort [Phase 3]
Phase 3 trial update describing an all-oral, shorter, individualized regimen for rifampicin-resistant tuberculosis using contezolid, delaman…
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Human-centered Design and Communities of Practice to Improve Home-based Tuberculosis Contact Investigation in Uganda [NA]
Completed Ugandan clinical trial assessing a human-centered design and communities of practice approach to improve home-based tuberculosis c…
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CLINICAL_TRIALS research · 2025-03-26Clinical Trial Update: Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath
A recruiting clinical trial aims to identify multiple pulmonary diseases by using volatile organic compound biomarkers in exhaled breath.
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CLINICAL_TRIALS research · 2025-03-25Clinical Trial Update: Short Course Regimen in Low Risk Active Tuberculosis- a Multicenter, Randomized, Active-controlled, Trial [Phase 3]
Multicenter Phase 3 randomized, active-controlled trial evaluating a short-course regimen for low-risk active pulmonary tuberculosis. Recrui…
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CLINICAL_TRIALS trial_result · 2025-03-11Clinical Trial Update: Study of TB Lesions Obtained in Therapeutical Surgery
The clinical trial NCT02715271 investigating TB lesions obtained during therapeutical surgery has completed.
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CLINICAL_TRIALS trial_result · 2025-02-25Clinical Trial Update: Impact of Malnutrition on Pharmacokinetic of Rifampicin, Isoniazid, Pyrazinamide and Ethambutol in TB-HIV Co-infected Children (TB-Speed TB-PK)
A completed clinical trial examines how malnutrition affects the pharmacokinetics of four first-line TB drugs (Rifampicin, Isoniazid, Pyrazi…
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CLINICAL_TRIALS trial_result · 2025-02-25Clinical Trial Update: Efficacy and Safety Evaluation of Two to Four Months of Treatment With the Combination Regimens of DBOS and PBOS in Adults With Pulmonary Tuberculosis [Phase 2]
Phase 2 trial evaluating two to four months of combination regimens with DBOS and PBOS for adults with pulmonary tuberculosis; the study has…
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CLINICAL_TRIALS research · 2025-02-17Clinical Trial Update: Phase 2 Trial Assessing TBAJ876 or Bedaquiline, with Pretomanid and Linezolid in Adults with Drug-sensitive Pulmonary Tuberculosis [Phase 2]
Phase 2 trial evaluating TBAJ876 or bedaquiline, with pretomanid and linezolid, for adults with drug-sensitive pulmonary tuberculosis.
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CLINICAL_TRIALS trial_result · 2025-02-10Clinical Trial Update: Evaluating Newly Approved Drugs for Multidrug-resistant TB [Phase 3]
Phase 3 clinical trials evaluating newly approved drugs for multidrug-resistant tuberculosis have completed, according to a trial update.
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: An Exploratory Study of TMC207 in Japanese Participants With Pulmonary Multi-Drug Resistant Tuberculosis (MDR-TB) [Phase 2]
An exploratory Phase 2 study of bedaquiline (TMC207) in Japanese patients with pulmonary multidrug-resistant tuberculosis has completed. The…
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CLINICAL_TRIALS research · 2025-01-06Clinical Trial Update: Evaluating Urine Isoniazid Testing to Detect Nonadherence to Tuberculosis Medications in India [NA]
A clinical trial in India is evaluating urine isoniazid testing as a method to detect nonadherence to tuberculosis medications. The study st…
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CLINICAL_TRIALS research · 2024-12-20Clinical Trial Update: Post TB Sequelae Study
Clinical trial update on a study evaluating post-tuberculosis sequelae; the trial is currently enrolling by invitation.
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CLINICAL_TRIALS trial_result · 2024-12-13Clinical Trial Update: Epidemiologic Study to Assess the IGRA Positivity in Populations With a High TB Burden
Clinical trial update for an epidemiologic study evaluating IGRA positivity in populations with a high tuberculosis burden has completed.
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CLINICAL_TRIALS research · 2024-12-10Clinical Trial Update: Cardiopulmonary Function and Quality of Life in Pulmonary Tuberculosis [NA]
The study, sponsored by Universidade Federal do Rio de Janeiro, is evaluating cardiopulmonary function and quality of life in individuals wi…
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CLINICAL_TRIALS trial_result · 2024-12-09Clinical Trial Update: A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of TBI-223 in Healthy Adults [Phase 1]
A Phase 1 trial evaluating safety, tolerability, and pharmacokinetics of the TB drug candidate TBI-223 in healthy adults has completed with …
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: A Systemic Screening for TB Disease in High-risk Groups in Barcelona
A clinical trial in Barcelona is testing systemic screening for tuberculosis disease in high-risk groups. The study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-11-12Clinical Trial Update: Adjunctive NAC in Adult Patients With Pulmonary Tuberculosis [Phase 2]
A Phase 2 clinical trial evaluating adjunctive N-acetylcysteine in adults with pulmonary tuberculosis has completed.
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CLINICAL_TRIALS research · 2024-11-06Clinical Trial Update: Observation Study on the Efficacy of Yiqi Gubiao Pill in the Treatment of Chronic Obstructive Pulmonary Disease Secondary to Active Pulmonary Tuberculosis [EARLY_Phase 1]
An early-phase observational study assessing Yiqi Gubiao Pill for chronic obstructive pulmonary disease secondary to active pulmonary tuberc…
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CLINICAL_TRIALS trial_result · 2024-10-28Clinical Trial Update: PanACEA DElpazolid Dose-finding and COmbination DEvelopment (DECODE) [Phase 2]
Phase 2 dose-finding and combination development trial of delpazolid for pulmonary tuberculosis completed; results posted.
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CLINICAL_TRIALS trial_result · 2024-10-24Clinical Trial Update: Collision of Three Global Pandemics: the Effect of Tuberculosis and HIV on the Epidemiological, Clinical, Virological and Immunological Trajectory of COVID-19 in Botswana and Namibia
This completed clinical trial update studied how HIV seropositivity and tuberculosis affect the epidemiology, clinical trajectory, virology,…
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CLINICAL_TRIALS trial_result · 2024-10-08Clinical Trial Update: A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults [Phase 1]
Phase 1 study assessing drug-drug interaction of TB antibiotic candidate TBAJ-876 in healthy adults has completed with results posted.
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CLINICAL_TRIALS trial_result · 2024-10-03Clinical Trial Update: Integrated Discovery and Development of Innovative TB Diagnostics
A Harvard-led clinical trial evaluating innovative diagnostics for pulmonary tuberculosis has completed, marking a registry status update.