Pulmonary Tuberculosis
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CLINICAL_TRIALS trial_result · 2024-11-12Clinical Trial Update: Adjunctive NAC in Adult Patients With Pulmonary Tuberculosis [Phase 2]
A Phase 2 clinical trial evaluating adjunctive N-acetylcysteine in adults with pulmonary tuberculosis has completed.
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CLINICAL_TRIALS trial_result · 2024-10-28Clinical Trial Update: PanACEA DElpazolid Dose-finding and COmbination DEvelopment (DECODE) [Phase 2]
Phase 2 dose-finding and combination development trial of delpazolid for pulmonary tuberculosis completed; results posted.
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CLINICAL_TRIALS trial_result · 2024-10-24Clinical Trial Update: Collision of Three Global Pandemics: the Effect of Tuberculosis and HIV on the Epidemiological, Clinical, Virological and Immunological Trajectory of COVID-19 in Botswana and Namibia
This completed clinical trial update studied how HIV seropositivity and tuberculosis affect the epidemiology, clinical trajectory, virology,…
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CLINICAL_TRIALS trial_result · 2024-10-08Clinical Trial Update: A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults [Phase 1]
Phase 1 study assessing drug-drug interaction of TB antibiotic candidate TBAJ-876 in healthy adults has completed with results posted.
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CLINICAL_TRIALS trial_result · 2024-10-03Clinical Trial Update: Integrated Discovery and Development of Innovative TB Diagnostics
A Harvard-led clinical trial evaluating innovative diagnostics for pulmonary tuberculosis has completed, marking a registry status update.
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary Tuberculosis [Phase 2]
Phase 2 trial evaluating the male reproductive safety of pretomanid in adult male participants with drug-resistant pulmonary tuberculosis; r…
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CLINICAL_TRIALS trial_result · 2024-08-09Clinical Trial Update: A Phase 3 Trial Assessing Safety and Efficacy of B-Pa-L in Participants With DR-TB [Phase 3]
A Phase 3 trial evaluating the safety and efficacy of B-Pa-L for drug-resistant pulmonary tuberculosis has completed, with results posted.
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CLINICAL_TRIALS trial_result · 2024-07-23Clinical Trial Update: A Clinical Risk Score for Early Management of TB in Uganda [NA]
A completed clinical trial in Uganda evaluated a clinical risk score for early management of pulmonary tuberculosis; results were posted in …
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CLINICAL_TRIALS trial_result · 2024-07-09Clinical Trial Update: Effect of Integrating Traditional Tuberculosis Care With Modern Health Care on Case Detection [NA]
A Bahir Dar University-led trial evaluating the integration of traditional tuberculosis care with modern health services has completed. The …
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CLINICAL_TRIALS trial_result · 2024-05-16Clinical Trial Update: Tuberculosis Research of INA-RESPOND On Drug Resistance
The clinical trial update reports completion of the INA-RESPOND tuberculosis drug-resistance study, with results posted in May 2024. The stu…
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CLINICAL_TRIALS trial_result · 2024-05-13Clinical Trial Update: Airborne Preventive Measures to Reduce New TB Infections in Household Contacts [NA]
The clinical trial NCT04938596 on airborne preventive measures to reduce new tuberculosis infections in household contacts has completed.
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CLINICAL_TRIALS trial_result · 2024-05-10Clinical Trial Update: Comparative Efficacy of CUS, CXR and CAD in TB Diagnosis in LMIC [NA]
This clinical trial from the University of Bari compares the diagnostic performance of chest ultrasound (CUS), chest X-ray (CXR), and comput…
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CLINICAL_TRIALS trial_result · 2024-04-11Clinical Trial Update: Early Bactericidal Activity of TBA-7371 in Pulmonary Tuberculosis [Phase 2]
Phase 2 clinical trial assessing early bactericidal activity of TBA-7371 in pulmonary tuberculosis has completed with results posted.
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CLINICAL_TRIALS trial_result · 2024-03-25Clinical Trial Update: Adjunctive Acetylsalicylic Acid and Ibuprofen for Tuberculosis [Phase 2]
Phase 2 clinical trial investigating adjunctive acetylsalicylic acid and ibuprofen for pulmonary and MDR tuberculosis; current status is unk…
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CLINICAL_TRIALS trial_result · 2024-02-26Clinical Trial Update: Azithromycin as Host-directed Therapy for Pulmonary Tuberculosis [Phase 2]
Phase 2 clinical trial exploring azithromycin as host-directed therapy for pulmonary tuberculosis has completed.
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CLINICAL_TRIALS trial_result · 2023-12-22Clinical Trial Update: BTZ-043 Dose Evaluation in Combination and Selection [Phase 2]
Phase 2 clinical trial evaluating BTZ-043 dose in combination therapy for pulmonary tuberculosis and other specified pulmonary tuberculosis.
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CLINICAL_TRIALS trial_result · 2023-11-18Clinical Trial Update: A Phase 1/2 Trial of Multiple Oral Doses of OPC-167832 for Uncomplicated Pulmonary Tuberculosis [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating multiple oral doses of OPC-167832 for uncomplicated pulmonary tuberculosis has completed with results …
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CLINICAL_TRIALS trial_result · 2023-11-08Clinical Trial Update: Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult Patients [Phase 2, Phase 3]
Phase 2/3 trial assessing the efficacy, safety, and tolerability of BPaMZ in drug-sensitive and drug-resistant pulmonary tuberculosis; study…
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CLINICAL_TRIALS trial_result · 2023-09-18Clinical Trial Update: StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With Tuberculosis [Phase 2]
A Phase 2b dose-finding study evaluating pravastatin as adjunctive therapy for tuberculosis has completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-09-11Clinical Trial Update: Evaluation of Early Bactericidal Activity and Safety in Pulmonary Tuberculosis With WX-081 [Phase 2]
Phase 2 trial evaluating early bactericidal activity and safety of WX-081 in pulmonary tuberculosis has been completed.
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CLINICAL_TRIALS trial_result · 2023-07-19Clinical Trial Update: Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB [Phase 2]
Phase 2 trial assessing early bactericidal activity of a rifampin-meropenem-amoxicillin/clavulanate combination in adults with pulmonary tub…
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CLINICAL_TRIALS trial_result · 2023-07-18Clinical Trial Update: Assessing PA-824 for Tuberculosis (the APT Trial) [Phase 2]
Phase 2 trial update for PA-824 ( pretomanid) in pulmonary tuberculosis; results completed with data posted.
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CLINICAL_TRIALS trial_result · 2023-06-29Clinical Trial Update: Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tuberculosis [Phase 3]
Phase 3 trial evaluating various doses and durations of a regimen including linezolid with bedaquiline and pretomanid for drug-resistant tub…
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CLINICAL_TRIALS trial_result · 2023-06-26Clinical Trial Update: The BLAST- 1 Trial - Cephalexin+Amoxicillin-clavulanate for Tuberculosis [Phase 2]
Phase 2 trial update for a combination of cephalexin and amoxicillin-clavulanate in pulmonary tuberculosis (BLAST-1).
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CLINICAL_TRIALS trial_result · 2023-06-18Clinical Trial Update: NexGen EBA Radiologic and Immunologic Biomarkers of Sterilizing Drug Activity in Tuberculosis [Phase 2]
Phase 2 clinical trial update investigating radiologic and immunologic biomarkers of sterilizing drug activity in pulmonary tuberculosis.