Pulmonary Arterial Hypertension
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CLINICAL_TRIALS trial_result · 2025-02-12Clinical Trial Update: Olaparib for PAH: a Multicenter Clinical Trial [Phase 1, Phase 2]
A multicenter Phase 1/Phase 2 trial of olaparib for pulmonary arterial hypertension has been terminated. The sponsor is Laval University.
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CLINICAL_TRIALS trial_result · 2025-02-11Clinical Trial Update: Safety and Effectiveness of a Virtual Pediatric Cardiac Rehabilitation Program or Telerehabilitation in Children With Heart Disease [NA]
This document reports the completion of a clinical trial evaluating the safety and effectiveness of a virtual pediatric cardiac rehabilitati…
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CLINICAL_TRIALS trial_result · 2025-02-10Clinical Trial Update: A Study to Learn About How Well Riociguat Works, How Safe it is and How it is Used Under Real World Conditions in Patients in the United States Who Are Receiving Riociguat for High Blood Pressure in the Arteries That Carry Blood From the Heart to the Lungs (Pulmonary Arterial Hypertension, PAH)
This completed real-world clinical trial update assesses the effectiveness, safety, and use of riociguat in United States patients with pulm…
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CLINICAL_TRIALS trial_result · 2025-02-04Clinical Trial Update: Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH) [Phase 3]
A Phase 3 trial evaluating the efficacy and safety of bosentan in sickle cell disease patients with pulmonary arterial hypertension was term…
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CLINICAL_TRIALS trial_result · 2025-02-04Clinical Trial Update: Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger Physiology [Phase 4]
Phase 4 trial update shows completion of study evaluating the effects of Tracleer (bosentan) on pulmonary arterial hypertension related to E…
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Bosentan in Children With Pulmonary Arterial Hypertension [Phase 3]
This Clinical Trial Update reports the completion of a Phase 3 study evaluating Bosentan in children with Pulmonary Arterial Hypertension.
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: The Effect of Tracleer® on Male Fertility [Phase 4]
Phase 4 trial evaluating the effect of Tracleer (bosentan) on male fertility in patients with pulmonary arterial hypertension has completed.
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Pulmonary Artery Remodelling With Bosentan [Phase 4]
Phase 4 study evaluating bosentan for pulmonary arterial hypertension has completed.
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: A Study of Real-world Cohort of Pulmonary Arterial Hypertension (PAH) Participants [Phase 4]
A Phase 4 real-world cohort study of Pulmonary arterial hypertension participants sponsored by Actelion has been terminated.
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Eisenmenger Quality Enhancement Research Initiative
The Eisenmenger Quality Enhancement Research Initiative trial sponsored by Actelion in pulmonary arterial hypertension has completed.
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CLINICAL_TRIALS trial_result · 2025-01-20Clinical Trial Update: Evaluation of the Prevalence and Clinical Manifestation of SARS-CoV-2 Infection in a Population of Adult and Pediatric Patients With Congenital Heart Disease
This completed clinical trial assessed the prevalence and clinical manifestations of SARS-CoV-2 infection in adult and pediatric patients wi…
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CLINICAL_TRIALS trial_result · 2025-01-16Clinical Trial Update: Evaluate Real-World Use of Next Generation Infusion Pumps to Administer Remodulin
A clinical trial update examining real-world use of next-generation infusion pumps to administer Remodulin for pulmonary arterial hypertensi…
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CLINICAL_TRIALS trial_result · 2025-01-13Clinical Trial Update: Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH)
A completed clinical trial at UT Southwestern Medical Center investigating metabolic remodeling in pulmonary arterial hypertension. The stud…
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CLINICAL_TRIALS trial_result · 2024-12-24Clinical Trial Update: A Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients with Renal Insufficiency and Healthy Subjects [Phase 1]
A Phase 1 pharmacokinetic and safety study of TPN171H tablets in patients with renal insufficiency and healthy subjects has completed.
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CLINICAL_TRIALS trial_result · 2024-12-24Clinical Trial Update: Acute Haemodynamic Study of TPN171H in Patients with Pulmonary Arterial Hypertension [Phase 2]
A Phase 2 clinical trial evaluating the acute hemodynamic effects of TPN171H in patients with pulmonary arterial hypertension has completed.
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension [Phase 2]
A Phase 2 clinical trial evaluating tamoxifen therapy for pulmonary arterial hypertension has completed, with results posted in December 202…
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CLINICAL_TRIALS trial_result · 2024-11-25Clinical Trial Update: Phase 1/1b Study With Nab-sirolimus for Patients With Severe Pulmonary Arterial Hypertension [Phase 1]
Phase 1/1b study of nab-sirolimus for severe pulmonary arterial hypertension has completed, with results posted in 2024.
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CLINICAL_TRIALS trial_result · 2024-11-20Clinical Trial Update: A Study of Selexipag in Participants Who Participated in a Previous Selexipag Study [Phase 3]
Phase 3 clinical trial update reporting results for selexipag in participants who previously took part in a prior selexipag study; results h…
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CLINICAL_TRIALS trial_result · 2024-11-01Clinical Trial Update: Open-label, Clinical Study to Evaluate the Safety and Tolerability of TreT in Subjects With PAH Currently Using Tyvaso [Phase 1]
An open-label Phase 1 study evaluated the safety and tolerability of TreT in patients with pulmonary arterial hypertension who are currently…
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CLINICAL_TRIALS trial_result · 2024-10-16Clinical Trial Update: Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension [Phase 2]
Phase 2 trial update from Vanderbilt University Medical Center evaluating interventions targeting insulin resistance in patients with pulmon…
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CLINICAL_TRIALS trial_result · 2024-10-16Clinical Trial Update: Safety, Tolerability and Pharmacokinetics of L608 in Healthy Adults [Phase 1]
This Phase 1 trial reports on the safety, tolerability and pharmacokinetics of L608 in healthy adults.
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CLINICAL_TRIALS trial_result · 2024-10-15Clinical Trial Update: Pharmacokinetics, Safety and Efficacy of BIA 5-1058 in PAH (Zamicastat) [Phase 2]
Phase 2 trial assessing pharmacokinetics, safety, and efficacy of Zamicastat (BIA 5-1058) in pulmonary arterial hypertension; study complete…
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension (IMPAHCT-FUL) [Phase 3]
The Phase 3 IMPAHCT-FUL trial evaluating inhaled imatinib for pulmonary arterial hypertension was terminated. Results have been posted.
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CLINICAL_TRIALS trial_result · 2024-10-04Clinical Trial Update: Effect of CS1 in Subjects With Pulmonary Arterial Hypertension [Phase 2]
A Phase 2 clinical trial evaluating CS1 in pulmonary arterial hypertension has completed.
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CLINICAL_TRIALS trial_result · 2024-09-23Clinical Trial Update: Subcutaneous Treprostinil as a Bridge to Lung Transplantation in Severe Pulmonary Hypertension: A Single-Arm Retrospective Study [Phase 4]
Phase 4 single-arm retrospective study assessing subcutaneous treprostinil as a bridge to lung transplantation in patients with severe pulmo…