Pulmonary Arterial Hypertension
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CLINICAL_TRIALS trial_result · 2025-09-12Clinical Trial Update: Study of ACT-293987 (NS-304) in Pulmonary Arterial Hypertension (PAH) [Phase 2]
This update reports the completion of a Phase 2 study of ACT-293987 (NS-304) for Pulmonary arterial hypertension conducted by Actelion.
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CLINICAL_TRIALS trial_result · 2025-09-10Clinical Trial Update: The Risk of Adverse Pregnancy Outcomes for Long-term Exposure to Air Pollution in Pregnant Patients With Pulmonary Hypertension
This clinical trial, now completed, studied the risk of adverse pregnancy outcomes associated with long-term exposure to air pollution in pr…
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CLINICAL_TRIALS trial_result · 2025-09-03Clinical Trial Update: Satralizumab in the Treatment of Pulmonary Arterial Hypertension (SATISFY-JP Trial) [Phase 2]
A Phase 2 clinical trial (SATISFY-JP) evaluating satralizumab for pulmonary arterial hypertension is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-08-22Clinical Trial Update: A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH) [Phase 3]
Phase 3 trial MK-7962-006/ZENITH evaluating sotatercept in pulmonary arterial hypertension patients at high mortality risk has completed and…
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: Single Ascending Dose Study for Evaluation of Safety, Tolerability and Pharmacokinetics of L606 [Phase 1]
Phase 1 single ascending dose study evaluating safety, tolerability, and pharmacokinetics of L606 has completed. The study targeted pulmonar…
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: Novel Index (PIMR) in PAH
A completed clinical study evaluating the Novel Index (PIMR) in pulmonary arterial hypertension, sponsored by the University of California, …
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: Quality of Life Assessed With the PAH SYMPACT Questionnaire
The clinical trial update summarizes quality-of-life findings in pulmonary hypertension using the PAH SYMPACT questionnaire.
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CLINICAL_TRIALS trial_result · 2025-07-10Clinical Trial Update: Melatonin for Pulmonary Hypertension in Full Term Neonates [Phase 3]
Phase 3 trial evaluating melatonin for pulmonary hypertension in full-term neonates has completed.
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CLINICAL_TRIALS trial_result · 2025-06-25Clinical Trial Update: A Study of Pulmonary Arterial Hypertension Participants Treated With Macitentan or Selexipag
A completed clinical trial update describing a study in pulmonary arterial hypertension comparing macitentan versus selexipag.
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: A Study of Rodatristat Ethyl in Patients With Pulmonary Arterial Hypertension (Core OLE) [Phase 2]
A Phase 2 Core OLE study of rodatristat ethyl in patients with pulmonary arterial hypertension has completed, and results were posted on 202…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: A Study of HS135 for the Treatment of Pulmonary Arterial Hypertension in Adults [Phase 1]
A Phase 1 clinical trial evaluating HS135 for pulmonary arterial hypertension in adults has been terminated.
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Study of Efficacy and Safety of LTP001 in Pulmonary Arterial Hypertension [Phase 2]
Phase 2 study of the investigational drug LTP001 in pulmonary arterial hypertension was terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: Study of Sotatercept in Newly Diagnosed Intermediate- and High-Risk PAH Participants (MK-7962-005/A011-13) [Phase 3]
Phase 3 study of sotatercept in newly diagnosed intermediate- and high-risk pulmonary arterial hypertension has completed.
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CLINICAL_TRIALS trial_result · 2025-05-07Clinical Trial Update: This Study Tests the Safety of Inhaled BAY1237592, How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) [Phase 1]
A Phase 1 trial evaluating the safety, tolerability, and preliminary effects of inhaled BAY1237592 in patients with pulmonary arterial hyper…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies. [Phase 3]
Phase 3 long-term safety study of macitentan in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertens…
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CLINICAL_TRIALS trial_result · 2025-04-22Clinical Trial Update: Bioequivalence Study to Compare Selexipag 400mcg Film Coated Tablets (400 mcg Selexipag) Versus Uptravi® 400mcg Film Coated Tablets (400 mcg Selexipag) [Phase 1]
Phase 1 bioequivalence study comparing Selexipag 400 mcg tablets to Uptravi 400 mcg tablets for pulmonary arterial hypertension has complete…
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: (RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment) [Phase 2]
The RIGHT HEART III Phase 2 trial evaluating right ventricular hemodynamics and response to treatment in pulmonary arterial hypertension has…
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: A Study of Single and Multiple Doses of Different Formulations of a Prostacyclin Receptor Agonist [Phase 1]
Phase 1 trial update reporting completion of single- and multiple-dose assessments of different formulations of a prostacyclin receptor agon…
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH [Phase 3]
Extension of the ORCHESTRA psychometric validation study in patients with pulmonary arterial hypertension; phase 3 trial completion reported…
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: HRV as a Marker of Treatment Response in PAH Arterial Hypertension
A completed clinical trial evaluating whether heart rate variability can serve as a biomarker for treatment response in pulmonary arterial h…
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CLINICAL_TRIALS trial_result · 2025-03-25Clinical Trial Update: Exercise Capacity Respiratory Muscle Strength Dyspnea and Physical Activity in Pediatric Pulmonary Arterial Hypertension
This completed clinical trial evaluated exercise capacity, respiratory muscle strength, dyspnea, and physical activity in pediatric patients…
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: Efficacy of Triple-Combination Therapy in Severe PAH-CHD
A clinical trial evaluating the efficacy of a triple-combination therapy for severe pulmonary arterial hypertension associated with congenit…
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CLINICAL_TRIALS trial_result · 2025-02-27Clinical Trial Update: A Study of Sotatercept in Japanese Pulmonary Arterial Hypertension (PAH) Participants (MK-7962-020) [Phase 3]
Phase 3 trial update for sotatercept in Japanese patients with pulmonary arterial hypertension; the study is completed and results have been…
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CLINICAL_TRIALS trial_result · 2025-02-21Clinical Trial Update: A Study of the Efficacy and Safety of Frespaciguat (MK-5475) in Participants With Pulmonary Arterial Hypertension (INSIGNIA-PAH: Phase 2/3 Study of an Inhaled sGC Stimulator in PAH) (MK-5475-007) [Phase 2, Phase 3]
A Phase 2/3 study (INSIGNIA-PAH) evaluated the inhaled sGC stimulator Frespaciguat (MK-5475) for pulmonary arterial hypertension; the trial …
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: Carnitine Consumption and Augmentation in Pulmonary Arterial Hypertension [Phase 1]
A Phase 1 study evaluating carnitine consumption and augmentation in pulmonary arterial hypertension has completed, with results posted.