Mediastinal Large B-cell Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2024-09-26Clinical Trial Update: Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy [Phase 2]
Phase 2 clinical trial evaluating epcoritamab versus observation in B-cell lymphoma patients not in complete remission after CD19-directed C…
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CLINICAL_TRIALS trial_result · 2024-08-26Clinical Trial Update: Polatuzumab Vedotin, Rituximab, Ifosfamide, Carboplatin, and Etoposide (PolaR-ICE) as Initial Salvage Therapy for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma [Phase 2]
Phase 2 study evaluating PolaR-ICE (polatuzumab vedotin, rituximab, ifosfamide, carboplatin, etoposide) as initial salvage therapy for relap…
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CLINICAL_TRIALS trial_result · 2024-08-21Clinical Trial Update: ENABLE-1 (Engaging Toll-like Receptor Signalling for B-cell Lymphoma Chimeric Antigen Receptor Therapy) [Phase 1]
The ENABLE-1 Phase 1 trial investigates Toll-like receptor signaling to enhance B-cell lymphoma CAR-T therapy, with the study currently list…
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CLINICAL_TRIALS trial_result · 2024-08-20Clinical Trial Update: CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies [Phase 1]
Phase 1 trial update for CLBR001 and SWI019 in relapsed/refractory B-cell malignancies has completed enrollment in a study targeting multipl…
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CLINICAL_TRIALS trial_result · 2024-08-13Clinical Trial Update: First-in-Human (FIH) Trial of GEN3009 in Subjects With Relapsed or Refractory B-Cell Non-Hodgkin Lymphomas [Phase 1, Phase 2]
First-in-human study of GEN3009 in relapsed or refractory B-cell non-Hodgkin lymphomas was terminated, with results posted thereafter.
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CLINICAL_TRIALS research · 2024-05-14Clinical Trial Update: A Prospective Study: Sintilimab and R-CHOP in PMBCL Treatment [Phase 2]
A Phase 2 clinical trial is evaluating sintilimab in combination with R-CHOP for primary mediastinal large B-cell lymphoma; the study is not…
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CLINICAL_TRIALS trial_result · 2024-02-01Clinical Trial Update: Pembrolizumab and Vorinostat in Patients With Relapsed or Refractory DLBCL, FCL or HL. [Phase 1]
Phase 1 study of pembrolizumab plus vorinostat in relapsed or refractory B-cell lymphomas and classic Hodgkin lymphoma; results posted in Fe…
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CLINICAL_TRIALS trial_result · 2024-01-23Clinical Trial Update: Copanlisib Hydrochloride and Nivolumab in Treating Patients With Recurrent or Refractory Diffuse Large B-cell Lymphoma or Primary Mediastinal Large B-cell Lymphoma [Phase 2]
A Phase 2 study evaluating the combination of copanlisib and nivolumab in patients with recurrent or refractory diffuse large B-cell lymphom…
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CLINICAL_TRIALS trial_result · 2023-08-04Clinical Trial Update: Study of Tazemetostat as Single Agent in Solid Tumors or B-cell Lymphomas and in Combination With Prednisolone in DLBCL [Phase 1, Phase 2]
Clinical trial update for tazemetostat as a single agent and in combination in B-cell lymphomas and solid tumors completed with results post…
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CLINICAL_TRIALS trial_result · 2023-03-16Clinical Trial Update: TC-110 T Cells in Adults With Relapsed or Refractory Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
Phase 1/2 trial update for TC-110 T cells in adults with relapsed or refractory non-Hodgkin lymphoma or acute lymphoblastic leukemia (comple…
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CLINICAL_TRIALS trial_result · 2022-08-24Clinical Trial Update: JCAR014 and Durvalumab in Treating Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma [Phase 1]
Phase 1 trial evaluating JCAR014 in combination with Durvalumab for relapsed or refractory B-cell non-Hodgkin lymphoma has been terminated; …
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CLINICAL_TRIALS trial_result · 2021-11-23Clinical Trial Update: Study Evaluating the Safety and Efficacy of KTE-C19 in Adult Participants With Refractory Aggressive Non-Hodgkin Lymphoma [Phase 1, Phase 2]
This document reports the completion of a Phase 1/2 trial evaluating axicabtagene ciloleucel (KTE-C19) for adults with refractory or relapse…
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CLINICAL_TRIALS trial_result · 2021-03-30Clinical Trial Update: Zanubrutinib Combined With Tislelizumab in the Treatment of r/r PMBCL and EBV+ DLBCL [Phase 2]
Phase 2 clinical trial evaluating zanubrutinib with tislelizumab for relapsed/refractory primary mediastinal large B-cell lymphoma and EBV-p…
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CLINICAL_TRIALS trial_result · 2020-10-23Clinical Trial Update: Study of LP002 for the Treatment of Patients With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma [Phase 2]
Phase 2 clinical trial update for LP002 in relapsed or refractory primary mediastinal large B-cell lymphoma (PMBCL).
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CLINICAL_TRIALS trial_result · 2020-06-24Clinical Trial Update: Study of Pembrolizumab (MK-3475) in Participants With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma or Relapsed or Refractory Richter Syndrome (MK-3475-170/KEYNOTE-170) [Phase 2]
Phase 2 study of pembrolizumab in relapsed/refractory primary mediastinal large B-cell lymphoma and Richter syndrome has completed with post…
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CLINICAL_TRIALS trial_result · 2019-09-17Clinical Trial Update: Brentuximab Vedotin and Chemotherapy in CD30+ PMBL, Diffuse Large B-Cell, and Grey Zone Lymphoma Patients [Phase 1, Phase 2]
Phase 1/2 study evaluating brentuximab vedotin with chemotherapy in CD30+ primary mediastinal large B-cell lymphoma, CD30+ diffuse large B-c…
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CLINICAL_TRIALS trial_result · 2019-04-23Clinical Trial Update: Study of Ibrutinib in Combination With Bendamustine and Rituximab for Patients With Relapsed/Refractory Aggressive BCL [Phase 2]
Phase 2 trial evaluating ibrutinib with bendamustine and rituximab for relapsed/refractory aggressive B-cell lymphomas, with several DLBCL-r…
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CLINICAL_TRIALS trial_result · 2018-12-03Clinical Trial Update: Two Stage Study of Combination of Chemotherapy, SHR-1210 and/or Decitabine for Relapsed/Refractory PMBCLs [Phase 1, Phase 2]
A two-stage Phase 1/2 trial evaluating chemotherapy in combination with SHR-1210 (a PD-1 inhibitor) and/or decitabine for relapsed/refractor…
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CLINICAL_TRIALS trial_result · 2018-11-01Clinical Trial Update: Pilot Study of Ruxolitinib in Relapsed or Refractory Hodgkin Lymphoma and Primary Mediastinal Large B-cell Lymphoma [Phase 2]
Phase 2 pilot study investigating ruxolitinib in relapsed or refractory Hodgkin lymphoma and primary mediastinal large B-cell lymphoma has c…
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CLINICAL_TRIALS withdrawal · 2017-11-30Clinical Trial Update: Rituximab and Combination Chemotherapy With or Without Bleomycin Sulfate in Treating Patients With Primary Mediastinal Large B-Cell Lymphoma [Phase 2]
Phase 2 clinical trial evaluating rituximab with or without bleomycin sulfate for primary mediastinal large B-cell lymphoma has been withdra…
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CLINICAL_TRIALS trial_result · 2017-08-15Clinical Trial Update: A Clinico-Pathologic Study of Primary Mediastinal B-Cell Lymphoma
Completed clinico-pathologic study of primary mediastinal large B-cell lymphoma, detailing clinical and pathological findings.
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CLINICAL_TRIALS trial_result · 2017-06-26Clinical Trial Update: A Study of SGN-35 (Brentuximab Vedotin) of Patients With Relapsed or Refractory PMLBCL [Phase 2]
Phase 2 trial results update for Brentuximab Vedotin (SGN-35) in patients with relapsed or refractory primary mediastinal large B-cell lymph…
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CLINICAL_TRIALS withdrawal · 2017-05-19Clinical Trial Update: Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma [Phase 2]
The Phase 2 trial of Brentuximab Vedotin, Bendamustine, and Rituximab for relapsed or refractory B-cell non-Hodgkin lymphoma has been withdr…
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CLINICAL_TRIALS withdrawal · 2016-11-25Clinical Trial Update: Efficacy and Safety Study of MDV9300 in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL) [Phase 2]
This clinical trial update states that the Phase 2 study of MDV9300 in relapsed or refractory diffuse large B-cell lymphoma has been withdra…
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CLINICAL_TRIALS trial_result · 2014-09-12Clinical Trial Update: CT-011 MAb in DLBCL Patients Following ASCT [Phase 2]
Phase 2 trial results for the CT-011 monoclonal antibody in diffuse large B-cell lymphoma patients following autologous stem cell transplant…