Biliary Cholangitis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-03-28Clinical Trial Update: Phase 2 Study of NGM282 in Patients With Primary Biliary Cirrhosis [Phase 2]
Phase 2 study of NGM282 in patients with primary biliary cholangitis has completed.
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CLINICAL_TRIALS trial_result · 2017-03-28Clinical Trial Update: Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis [Phase 4]
This clinical-trial update notes the completion of a Phase 4 study assessing the effectiveness of S-adenosyl-L-methionine in patients with p…
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CLINICAL_TRIALS trial_result · 2017-03-28Clinical Trial Update: Phase 2b Study of NGM282 Extended Treatment in Patients With Primary Biliary Cirrhosis [Phase 2]
Phase 2b study of NGM282 for primary biliary cholangitis has completed; the update notes the trial status as COMPLETED.
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CLINICAL_TRIALS trial_result · 2017-02-23Clinical Trial Update: IBAT Inhibitor A4250 for Cholestatic Pruritus [Phase 2]
A Phase 2 trial of the IBAT inhibitor A4250 for cholestatic pruritus in primary biliary cholangitis was terminated.
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CLINICAL_TRIALS trial_result · 2017-01-13Clinical Trial Update: B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis [Phase 2]
Phase 2 trial evaluating rituximab, a B-cell depleting therapy, for fatigue in primary biliary cholangitis has completed.
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CLINICAL_TRIALS research · 2016-09-27Clinical Trial Update: Fuzhenghuayu in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis [Phase 3]
This is an update on a Phase 3 trial evaluating Fuzhenghuayu in combination with ursodeoxycholic acid for primary biliary cholangitis. The s…
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CLINICAL_TRIALS trial_result · 2016-09-27Clinical Trial Update: Fuzhenghuayu for Patients With PBC Who Had An Inadequate Response to Ursodeoxycholic Acid [Phase 3]
Phase 3 clinical trial update for Fuzhenghuayu in patients with primary biliary cholangitis who did not respond adequately to ursodeoxycholi…
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CLINICAL_TRIALS trial_result · 2016-08-24Clinical Trial Update: Pilot Study of FFP104 Dose Escalation in PBC Subjects [Phase 1, Phase 2]
Pilot dose-escalation study of FFP104 in subjects with Primary Biliary Cholangitis (Phase 1/Phase 2) with current status listed as unknown.
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FDA approval · 2016-06-27FDA Approved: URSODIOL — Supplemental Application (Actavis Pharma, Inc.)
The FDA approved a supplemental application for Ursodiol by Actavis Pharma, Inc., updating its labeling and indications. The action likely e…
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CLINICAL_TRIALS research · 2016-03-08Clinical Trial Update: The Effect of Bezafibrate on Cholestatic Itch [Phase 3]
Phase 3 trial investigating bezafibrate for reducing cholestatic itch in patients with cholestatic liver diseases; status is not specified.
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FDA approval · 2015-10-26FDA Approved: URSODIOL — Supplemental Application (BluePoint Laboratories)
The FDA approved a supplemental application for URSODIOL (ursodiol) from BluePoint Laboratories. This confirms regulatory clearance for the …
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CLINICAL_TRIALS trial_result · 2015-02-23Clinical Trial Update: Biliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CT [Phase 1]
Phase 1 study assessing biliary excretion of conjugated bile acids in humans using 11C-cholylsarcosine PET/CT; the trial was completed and r…
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CLINICAL_TRIALS trial_result · 2014-10-15Clinical Trial Update: A Study of Efficacy and Safety of Ustekinumab in Patients With Primary Biliary Cirrhosis (PBC) Who Had an Inadequate Response to Ursodeoxycholic Acid [Phase 2]
A Phase 2 trial evaluating the efficacy and safety of ustekinumab in patients with primary biliary cholangitis who had an inadequate respons…
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CLINICAL_TRIALS trial_result · 2014-04-04Clinical Trial Update: Primary Biliary Cirrhosis: Investigating A New Treatment Option Using NI-0801, an Anti-CXCL10 Monoclonal Antibody [Phase 2]
A Phase 2 trial of NI-0801, an anti-CXCL10 monoclonal antibody, for primary biliary cholangitis was terminated.
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CLINICAL_TRIALS trial_result · 2014-03-24Clinical Trial Update: Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC [Phase 3]
Phase 3 efficacy and safety trial comparing tauroursodeoxycholic acid (TUDCA) with ursodeoxycholic acid (UDCA) for primary biliary cholangit…
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CLINICAL_TRIALS trial_result · 2013-12-09Clinical Trial Update: Pentoxifylline for Primary Biliary Cirrhosis [Phase 2]
Phase 2 trial results for pentoxifylline in primary biliary cholangitis have been posted following completion of the study.
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FDA approval · 2013-08-21FDA Approved: URSO 250 — Supplemental Application (Allergan, Inc.)
FDA approved Allergan's supplemental application for URSO 250 (ursodiol), adding a 250 mg strength to the product label.
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CLINICAL_TRIALS trial_result · 2013-05-20Clinical Trial Update: Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis [Phase 3]
Phase 3 trial comparing Tauroursodeoxycholic acid to Ursofalk for adult primary biliary cholangitis has completed.
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FDA approval · 2013-02-14FDA Approved: URSODIOL — Original Application (Endo USA, Inc.)
The FDA approved Ursodiol (ursodeoxycholic acid) under an original ANDA submitted by Endo USA, Inc.
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CLINICAL_TRIALS withdrawal · 2012-10-08Clinical Trial Update: Stem Cell Transplantation in Patients With Primary Biliary Cirrhosis [Phase 1]
Phase 1 clinical trial of stem cell transplantation for primary biliary cholangitis has been withdrawn.
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CLINICAL_TRIALS research · 2012-08-03Clinical Trial Update: Efficacy and Safety Study of Allogenic Mesenchymal Stem Cells for Patients With Refractory Primary Biliary Cirrhosis [Phase 1]
This is a Phase 1 clinical trial evaluating the safety and potential efficacy of allogeneic mesenchymal stem cells in patients with refracto…
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CLINICAL_TRIALS trial_result · 2012-01-18Clinical Trial Update: Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis (PBC) [Phase 1]
Phase 1 trial evaluating modafinil for fatigue in patients with primary biliary cholangitis has completed. The study assessed safety and fea…
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CLINICAL_TRIALS trial_result · 2012-01-09Clinical Trial Update: Use of Fenofibrate for Primary Biliary Cirrhosis [Phase 2]
A Phase 2 clinical trial evaluating fenofibrate for primary biliary cholangitis has completed and results were posted in January 2012.
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FDA approval · 2011-07-12FDA Approved: URSODIOL — Original Application (BluePoint Laboratories)
FDA approved the original (generic) application for URSODIOL from BluePoint Laboratories.
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CLINICAL_TRIALS trial_result · 2011-04-04Clinical Trial Update: Pharmacokinetic Study Of Tigecycline In Adult Subjects With Primary Biliary Cirrhosis [Phase 1]
Phase 1 pharmacokinetic study evaluating tigecycline in adult subjects with primary biliary cholangitis (biliary liver cirrhosis). The study…