Periapical Periodontitis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-08-19Clinical Trial Results: Comparison of Clinical Outcomes Between GentleWave® and Biolase® [NA]
Clinical trial comparing outcomes of GentleWave versus Biolase in endodontic disease conditions; results posted after completion.
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions [NA]
A clinical trial compares Mineral Trioxide Aggregate (MTA) against gutta-percha for non-surgical retreatment of teeth with apical lesions; t…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment [NA]
A clinical trial update comparing two medicines for healing jaw bone infections after root canal treatment; the study is currently not yet r…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment [NA]
A clinical trial evaluating the effectiveness of i-PRF as a revitalization approach in non-surgical root canal retreatment, currently recrui…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Cryotherapy and Intracanal Medicaments for Postoperative Pain in Apical Periodontitis [Phase 2]
Phase 2 clinical trial evaluating cryotherapy and intracanal medicaments for postoperative pain in periapical periodontitis has completed.
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis [NA]
This clinical trial update reports on a completed study examining the roles of prostaglandin and nitric oxide synthesis in periapical period…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Comparison of Root Canal Desinfection Protocols [NA]
A clinical trial update from State University of New York at Buffalo is evaluating different root canal disinfection protocols for periapica…
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical Periodontitis [NA]
This completed clinical trial evaluated the effect of EDDY Sonic Irrigation on root canal microbiota and pain in asymptomatic apical periodo…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Clinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic Retreatments
A protocol update for a clinical trial evaluating primary endodontic treatment and non-surgical retreatment in patients with periapical peri…
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars [NA]
This clinical trial evaluated the impact of targeted endodontic microsurgery on quality of life and healing in mandibular molars; the study …
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Single-Visit and Two-Visit Endodontic Treatments [NA]
Completed study assessing single-visit versus two-visit endodontic treatments for endodontic infection and periapical periodontitis, sponsor…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: THE EFFECT OF ENDODONTIC TREATMENT ON CARDIOVASCULAR RISK BIOMARKERS IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE [NA]
A clinical trial is evaluating whether endodontic treatment affects cardiovascular risk biomarkers in patients with stable coronary artery d…
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CLINICAL_TRIALS trial_result · 2025-12-24Clinical Trial Update: Effects of Different Irrigation Activation Techniques on the Healing of Large Periapical Lesions [NA]
A completed clinical trial from Recep Tayyip Erdogan University evaluated different irrigation activation techniques (including lasers) for …
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: PRF and CGF Scaffolds With EDTA in Regeneration [NA]
This entry reports a completed clinical trial evaluating PRF and CGF scaffolds with EDTA for regenerative endodontics in immature permanent …
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CLINICAL_TRIALS other · 2025-12-01Clinical Trial Update: Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication [NA]
Clinical trial evaluating the antimicrobial and anti-inflammatory effects of simvastatin as an intracanal medication for endodontic disease …
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Comparison of Frequency of Calcium Hydroxide Mixed With 0.2% Chlorhexidine Versus Saline as Intracanal Medicament in Periapical Periodontitis-A Randomized Controlled Trial [NA]
This is an ongoing randomized trial comparing calcium hydroxide mixed with 0.2% chlorhexidine versus saline as an intracanal medicament for …
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars [NA]
The document describes a clinical trial evaluating if maintaining apical patency affects post-endodontic pain in molars. The sponsor is Coll…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing [Phase 2]
Phase 2 clinical trial evaluating different intracanal dressings for improving periapical healing in failed root canal cases has completed.
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Healing After Endodontic Microsurgery Using a Rotary Bur Versus Piezoelectric Unit for Osteotomy and Root Resection [NA]
A clinical trial is recruiting to compare a rotary bur versus a piezoelectric unit for osteotomy and root resection in endodontic microsurge…
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: Efficacy of 810 nm Diode Laser Disinfection on Inflammatory Cytokines and Postoperative Pain After Endodontic Retreatment [NA]
A clinical trial is currently recruiting to evaluate whether 810 nm diode laser disinfection influences inflammatory cytokines and postopera…
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CLINICAL_TRIALS trial_result · 2025-08-24Clinical Trial Update: Three Techniques in Bioceramic Apexification for Necrotic Immature Incisors [NA]
Clinical trial completion update on three bioceramic apexification techniques for necrotic immature incisors, sponsored by Damascus Universi…
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: Comparison of Clinical Outcomes Between GentleWave® and Biolase® [NA]
A completed clinical trial evaluating clinical outcomes between the GentleWave dental system and a Biolase device for endodontic and related…
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CLINICAL_TRIALS research · 2025-08-03Clinical Trial Update: Effect of Local Use of Non-steroidal Anti-inflammatory Agent (Diclofenac Sodium) With and Without Hyaluronidase on Post-surgical Pain and Swelling [NA]
A clinical trial evaluating diclofenac sodium with and without hyaluronidase for postoperative pain and swelling after root-end resection fo…
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CLINICAL_TRIALS trial_result · 2025-07-30Clinical Trial Update: Application of Advanced Platelet-Rich Fibrin Plus (A-PRF+) in Revascularisation of Necrotic Immature Permanent Teeth [NA]
A clinical trials update reports the completion of a study evaluating Advanced Platelet-Rich Fibrin Plus (A-PRF+) for revascularization of n…
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CLINICAL_TRIALS trial_result · 2025-07-29Clinical Trial Update: Evaluation of the Efficacy of Growth Hormone, EndoSeal MTA Sealer, and Their Combination on Healing of Periapical Pathosis [NA]
A completed clinical trial evaluated the efficacy of Growth Hormone, EndoSeal MTA Sealer, and their combination for healing periapical patho…