Partial Epilepsy
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CLINICAL_TRIALS trial_result · 2018-07-05Clinical Trial Update: Brain P-gp and Inflammation in People With Epilepsy
This clinical trial update reports the completion of a study evaluating brain P-glycoprotein and inflammation in people with partial epileps…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Study of PK and Safety of OXC (Oxcarbazepine) XR (Extended Release) as Adjunctive Therapy in Pediatric Epilepsy Patients [Phase 1]
A Phase 1 study evaluated the pharmacokinetics and safety of oxcarbazepine extended-release as adjunctive therapy in pediatric patients with…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Serotonin Receptors in Seizure Disorders
An update on a completed clinical trial exploring the role of serotonin receptors in partial epilepsy, sponsored by the National Institute o…
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CLINICAL_TRIALS trial_result · 2016-12-05Clinical Trial Update: Randomized Controlled Trial to Assess Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy [Phase 4]
A Phase 4 randomized trial assessed lacosamide's effects on sleep and wakefulness in adults with focal epilepsy. The study completed and res…
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CLINICAL_TRIALS trial_result · 2016-01-27Clinical Trial Update: Localizing the Epileptogenic Zone With High Resolution Electroencephalography [NA]
A completed clinical trial evaluated high-resolution electroencephalography to localize the epileptogenic zone in patients with partial epil…
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CLINICAL_TRIALS trial_result · 2015-08-20Clinical Trial Update: Levetiracetam Versus Oxcarbazepine as Monotherapy to Evaluate Efficacy and Safety in Subjects With Newly or Recently Diagnosed Partial Epilepsy [Phase 4]
A Phase 4 study compared levetiracetam with oxcarbazepine as monotherapy in patients with newly or recently diagnosed partial epilepsy, with…
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CLINICAL_TRIALS trial_result · 2014-12-19Clinical Trial Update: Study to Evaluate Pharmacokinetics and Tolerability of Multiple Doses of Eslicarbazepine Acetate and Oxcarbazepine [Phase 1]
Phase 1 study evaluating the pharmacokinetics and tolerability of multiple doses of eslicarbazepine acetate and oxcarbazepine in partial epi…
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CLINICAL_TRIALS trial_result · 2014-12-12Clinical Trial Update: Effect of Repeat Administration of Eslicarbazepine Acetate on the Pharmacokinetics of a Combined Oral Contraceptive [Phase 1]
Phase 1 study evaluating whether repeat administration of eslicarbazepine acetate affects the pharmacokinetics of a combined oral contracept…
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CLINICAL_TRIALS trial_result · 2014-11-26Clinical Trial Update: Hormonal and Lipid Levels in Male Subjects After a Switch From Carbamazepine to Lacosamide [Phase 3]
A Phase 3 trial assessing hormonal and lipid changes in male subjects after switching from carbamazepine to lacosamide for epilepsy; the stu…
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CLINICAL_TRIALS trial_result · 2014-07-22Clinical Trial Update: Vimpat® Added as Adjunctive Therapy to One Baseline Antiepileptic Drug
Trial evaluated Vimpat (lacosamide) as adjunctive therapy to one baseline antiepileptic drug in partial epilepsy; results have been posted a…
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CLINICAL_TRIALS trial_result · 2014-04-15Clinical Trial Update: Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) as Adjunctive Therapy for Refractory Partial Seizures [Phase 3]
Phase 3 trial updating on the efficacy and safety of eslicarbazepine acetate as adjunctive therapy for refractory partial seizures.
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CLINICAL_TRIALS trial_result · 2014-02-11Clinical Trial Update: Evaluation of Efficacy and Safety of OXC XR as Adjunctive Therapy for Partial Seizures [Phase 3]
Phase 3 trial evaluating the efficacy and safety of OXC XR as adjunctive therapy for partial seizures; results have been posted.
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CLINICAL_TRIALS trial_result · 2014-01-27Clinical Trial Update: Study of VX-765 in Subjects With Treatment-resistant Partial Epilepsy [Phase 2]
This document announces the completion of a Phase 2 study of VX-765 in adults with treatment-resistant partial epilepsy.
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CLINICAL_TRIALS trial_result · 2013-11-26Clinical Trial Update: Open Label Safety and Efficacy Study of Levetiracetam in Korean Patients With Epilepsy [Phase 3]
Open-label Phase 3 safety and efficacy study of levetiracetam in Korean patients with partial epilepsy has completed.
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CLINICAL_TRIALS trial_result · 2013-11-15Clinical Trial Update: Trial to Evaluate the Safety and Efficacy of Keppra After Conversion to Mono-therapy in Subjects With Partial Epilepsy [Phase 4]
Phase 4 trial evaluating the safety and efficacy of levetiracetam (Keppra) as monotherapy after conversion in subjects with partial epilepsy…
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CLINICAL_TRIALS trial_result · 2013-11-15Clinical Trial Update: Pharmacovigilance Study of Keppra. SPAIN - SKATE : Safety of Keppra as Adjunctive Therapy in Epilepsy [Phase 4]
This report notes the completion of a Phase 4 pharmacovigilance study (SKATE) evaluating the safety of Keppra (levetiracetam) as adjunctive …
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CLINICAL_TRIALS trial_result · 2013-09-10Clinical Trial Update: Improving Lesion Detection in Children With Magnetic Resonance Imaging (MRI)-Negative Partial Epilepsy Using Diffusion Tensor Imaging
A completed clinical trial evaluating diffusion tensor imaging to improve lesion detection in children with MRI-negative partial epilepsy.
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CLINICAL_TRIALS trial_result · 2013-08-05Clinical Trial Update: Efficacy and Safety of Eslicarbazepine Acetate as Adjunctive Therapy for Refractory Partial Epilepsy [Phase 3]
Phase 3 trial evaluating eslicarbazepine acetate as add-on therapy for adults with refractory partial epilepsy; results assess efficacy and …
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CLINICAL_TRIALS trial_result · 2013-08-05Clinical Trial Update: Efficacy and Safety Study of BIA 2-093 in Combination With Other Anti-Epileptic Drugs to Treat Partial Epilepsy [Phase 3]
This clinical trial update reports results from a Phase 3 study of BIA 2-093 in combination with other anti-epileptic drugs for partial epil…
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CLINICAL_TRIALS trial_result · 2013-06-21Clinical Trial Update: Thermographic Examination of Skin Temperatures in Individuals With Focal Onset Epilepsy
A completed clinical trial evaluating thermographic assessment of skin temperature patterns in individuals with focal epilepsy.
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EMA guidance · 2013-05-31European Medicines Agency recommends restricting Trobalt to last-line therapy in partial epilepsy
The EMA recommends restricting Trobalt (vigabatrin) to last-line therapy for partial epilepsy due to safety concerns.
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CLINICAL_TRIALS research · 2013-05-27Clinical Trial Update: An Observational Study to Assess the Burden of Drug-resistant Partial Epilepsy in Italy
An observational study conducted in Italy to assess the burden of drug-resistant partial epilepsy, sponsored by GlaxoSmithKline, has complet…
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CLINICAL_TRIALS trial_result · 2013-02-08Clinical Trial Update: A Double-blind Study to Compare the Efficacy and Safety of Zonisamide and Carbamazepine as Monotherapy, in Newly Diagnosed Partial Epilepsy [Phase 3]
Phase 3 double-blind trial comparing zonisamide with carbamazepine as monotherapy in newly diagnosed partial epilepsy; the study assesses ef…
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CLINICAL_TRIALS trial_result · 2013-01-24Clinical Trial Update: An Open-Label Extension Study to Evaluate the Safety and Effectiveness of RWJ 333369 in Patients With Epilepsy [Phase 2]
An open-label extension study evaluating the safety and effectiveness of RWJ 333369 in epilepsy has completed Phase 2.
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CLINICAL_TRIALS trial_result · 2013-01-24Clinical Trial Update: An Open-Label Extension Study of the Effectiveness and Safety of the Investigational Compound RWJ-333369 in Patients With Epilepsy [Phase 2]
Open-label extension study results for RWJ-333369 in epilepsy have completed Phase 2 evaluation, focusing on safety and effectiveness in pat…