Paroxysmal Nocturnal Hemoglobinuria
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CLINICAL_TRIALS trial_result · 2018-10-31Clinical Trial Update: Eculizumab Pharmacokinetics/Pharmacodynamics Study in Pediatric/Adolescent Paroxysmal Nocturnal Hemoglobinuria (PNH) [Phase 4]
Phase 4 pharmacokinetics/pharmacodynamics study of eculizumab in pediatric/adolescent paroxysmal nocturnal hemoglobinuria has completed with…
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CLINICAL_TRIALS trial_result · 2018-03-13Clinical Trial Update: Safety and Efficacy Study of Eculizumab in Paroxysmal Nocturnal Hemoglobinuria Patients [Phase 2]
Phase 2 clinical trial of eculizumab in patients with paroxysmal nocturnal hemoglobinuria has completed, with results posted detailing safet…
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CLINICAL_TRIALS trial_result · 2018-01-30Clinical Trial Update: Dose-Escalation Study of ALXN1210 IV in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) [Phase 1, Phase 2]
A dose-escalation study of ALXN1210 IV in people with paroxysmal nocturnal hemoglobinuria (PNH) has completed Phase 1/2 with results posted.
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CLINICAL_TRIALS trial_result · 2017-10-18Clinical Trial Update: Paroxysmal Nocturnal Hemoglobinuria Human Anti-Human Antibodies Study
Clinical trial update indicating that a study on human anti-human antibodies in Paroxysmal nocturnal hemoglobinuria (PNH) has completed.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria [Phase 3]
This document reports a Phase 3 clinical trial evaluating eculizumab for paroxysmal nocturnal hemoglobinuria, with the trial status listed a…
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CLINICAL_TRIALS trial_result · 2017-06-05Clinical Trial Update: Extension Study of Eculizumab in Patients With Transfusion Dependent Paroxysmal Nocturnal Hemoglobinuria (PNH) [Phase 3]
Phase 3 extension study of eculizumab in transfusion-dependent paroxysmal nocturnal hemoglobinuria has completed and posted results in 2017.
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CLINICAL_TRIALS trial_result · 2017-03-10Clinical Trial Update: Trial of Allogeneic Stem Cell Transplants From HLA Compatible, Related and Unrelated Donors After a Myeloablative Preparative Regimen With Hyperfractionated TBI, Thiotepa and Fludarabine For Adult Patients With Lymphohematopoietic Disorders [Phase 2]
Phase 2 trial evaluating myeloablative conditioning with hyperfractionated total body irradiation plus thiotepa and fludarabine followed by …
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CLINICAL_TRIALS trial_result · 2016-05-03Clinical Trial Update: Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies [Phase 2]
Phase 2 clinical trial update on mismatched family member donor stem cell transplantation in children and young adults with high-risk hemato…
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CLINICAL_TRIALS trial_result · 2016-03-03Clinical Trial Update: Peripheral Blood Stem Cell Transplantation (PBSCT)From Haploidentical Related Donors [Phase 2]
Phase 2 results from a trial of peripheral blood stem cell transplantation using haploidentical related donors were completed, led by the Un…
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CLINICAL_TRIALS trial_result · 2015-12-31Clinical Trial Update: Donor Stem Cell Transplant After Busulfan, Fludarabine, Methylprednisolone, and Antithymocyte Globulin in Treating Patients With Bone Marrow Failure Syndrome [Phase 2]
Phase 2 trial evaluating donor stem cell transplantation after a busulfan/fludarabine/methylprednisolone/antithymocyte globulin conditioning…
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CLINICAL_TRIALS trial_result · 2014-10-28Clinical Trial Update: Microvascular and Cardiac Dysfunction in Paroxysmal Nocturnal Hemoglobinuria and Sickle Cell Disease
This update summarizes a completed clinical trial investigating microvascular and cardiac dysfunction in Paroxysmal Nocturnal Hemoglobinuria…
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CLINICAL_TRIALS trial_result · 2014-05-22Clinical Trial Update: Safety and Pharmacokinetics of TT30 in Subjects With Paroxysmal Nocturnal Hemoglobinuria (PNH) [Phase 1]
A Phase 1 study evaluated the safety and pharmacokinetics of TT30 in patients with paroxysmal nocturnal hemoglobinuria. The trial was termin…
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CLINICAL_TRIALS approval · 2014-05-06Clinical Trial Update: The Paroxysmal Nocturnal Hemoglobinuria Early Access Treatment Protocol
Marketing approval has been granted for eculizumab as a treatment for paroxysmal nocturnal hemoglobinuria under the sponsor's early access t…
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CLINICAL_TRIALS trial_result · 2013-11-11Clinical Trial Update: Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes [Phase 2]
Phase 2 trial update of an allogeneic mixed chimerism stem cell transplant using Campath (alemtuzumab) for hemoglobinopathies and bone marro…
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CLINICAL_TRIALS trial_result · 2013-05-30Clinical Trial Update: Eculizumab in Treating Patients With Paroxysmal Nocturnal Hemoglobinuria [Phase 3]
A Phase 3 clinical trial update for eculizumab in paroxysmal nocturnal hemoglobinuria shows the study status as completed.
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CLINICAL_TRIALS trial_result · 2013-01-09Clinical Trial Update: Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer [Phase 1]
Phase 1 study assessing the safety of adding sargramostim (GM-CSF) to chemotherapy in patients with refractory myeloid cancers; the trial ha…
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CLINICAL_TRIALS trial_result · 2013-01-03Clinical Trial Update: Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Classic Paroxysmal Nocturnal Hemoglobinuria [Phase 2]
Phase 2 clinical trial update evaluating the safety and efficacy of combining levamisole with cyclosporine A in patients with paroxysmal noc…
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CLINICAL_TRIALS trial_result · 2013-01-03Clinical Trial Update: Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013) [Phase 2]
Phase 2 trial evaluating the safety and efficacy of combining levamisole with cyclosporine A in patients with paroxysmal nocturnal hemoglobi…
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FDA approval · 2012-12-21FDA Approved: SOLIRIS — Supplemental Application (Alexion Pharmaceuticals Inc.)
FDA approved a supplemental application for SOLIRIS (eculizumab) submitted by Alexion Pharmaceuticals, resulting in changes to the product l…
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CLINICAL_TRIALS research · 2011-08-09Clinical Trial Update: The Molecular Biology of Paroxysmal Nocturnal Hemoglobinuria (PNH)
An update on the molecular biology of paroxysmal nocturnal hemoglobinuria (PNH) from a completed University of Utah clinical trial.
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CLINICAL_TRIALS research · 2010-10-20Clinical Trial Update: Multicenter Retrospective Analysis About the Clinical Characteristics of Korean Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients
A multicenter retrospective analysis from Samsung Medical Center describing the clinical characteristics of Korean patients with paroxysmal …
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CLINICAL_TRIALS trial_result · 2010-09-01Clinical Trial Update: Paroxysmal Nocturnal Hemoglobinuria (PNH), Level of CD59 on Red and White Blood Cells in Bone Marrow Failure Syndromes
Completed clinical trial evaluating the level of CD59 on red and white blood cells in patients with paroxysmal nocturnal hemoglobinuria and …
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CLINICAL_TRIALS research · 2010-04-21Clinical Trial Update: Identifying Characteristics of Bone Marrow Failure Syndromes
This clinical trial update describes a study to identify characteristics of bone marrow failure syndromes and related hematologic conditions…
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CLINICAL_TRIALS trial_result · 2009-02-13Clinical Trial Update: Haploidentical Stem Cell Transplant for Treatment Refractory Hematological Malignancies [Phase 2]
A Phase 2 clinical trial from St. Jude evaluated haploidentical hematopoietic stem cell transplantation for treatment-refractory hematologic…
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CLINICAL_TRIALS trial_result · 2009-01-29Clinical Trial Update: Haploidentical Stem Cell Transplantation for Patients With Hematologic Malignancies [Phase 3]
This document reports a Phase 3 clinical trial evaluating haploidentical hematopoietic stem cell transplantation in patients with hematologi…