Parkinson Disease

• CLINICAL_TRIALS research · 2026-02-18
  Clinical Trial Update: Closed Loop DBS Implanted RC+S Study [NA]

  This entry reports an ongoing clinical trial of a closed-loop deep brain stimulation (RC+S) system for Parkinson disease, with enrollment by…

• CLINICAL_TRIALS research · 2026-02-18
  Clinical Trial Update: Safety and Pharmacodynamic Effects of BIIB122 in Participants With LRRK2-Associated Parkinson's Disease (LRRK2-PD) [Phase 2]

  Phase 2 clinical trial evaluating safety and pharmacodynamic effects of BIIB122 in individuals with LRRK2-associated Parkinson's disease; re…

• CLINICAL_TRIALS research · 2026-02-18
  Clinical Trial Update: LIFUS For Neurological Disorders [NA]

  This clinical trial is evaluating low-intensity focused ultrasound (LIFUS) for several neurological disorders and is currently recruiting, i…

• CLINICAL_TRIALS research · 2026-02-18
  Clinical Trial Update: A Prospective, Randomized, Controlled Trial to Test Safety and Effectiveness of Unilateral Exablate MR-guided Focused Ultrasound Subthalamotomy in Patients With Early-Stage Parkinson's Disease [NA]

  A prospective, randomized trial is evaluating the safety and effectiveness of unilateral subthalamotomy using MR-guided focused ultrasound i…

• CLINICAL_TRIALS research · 2026-02-18
  Clinical Trial Update: Radiation Therapy (RT) for Parkinson's Disease (PD) [NA]

  Mayo Clinic sponsors a clinical trial evaluating radiation therapy for Parkinson's disease, currently enrolling by invitation.

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• CLINICAL_TRIALS research · 2026-02-18
  Clinical Trial Update: Aquatic High-Intensity Interval Training for Parkinson's Disease [NA]

  An ongoing clinical trial is evaluating aquatic high-intensity interval training for Parkinson disease. The study is currently recruiting.

• CLINICAL_TRIALS research · 2026-02-17
  Clinical Trial Update: Real-World Study of Foslevodopa/Foscarbidopa to Assess Quality of Life Outcomes in Adult Participants Earlier Within Advanced Parkinson Disease

  This clinical trial entry describes a real-world study evaluating quality of life outcomes for Foslevodopa/Foscarbidopa in adults with advan…

• CLINICAL_TRIALS research · 2026-02-17
  Clinical Trial Update: Detection of Internal Tremors by Oscillometry in Parkinson's Patient [NA]

  An ongoing clinical trial at University Hospital, Toulouse is investigating detection of internal tremors in Parkinson disease patients usin…

• CLINICAL_TRIALS research · 2026-02-17
  Clinical Trial Update: Role of Slow Waves in the Progression of Neurodegeneration in Isolated REM Sleep Behavior Disorder [NA]

  A university-sponsored clinical trial is investigating the role of slow brain waves in the progression of neurodegeneration in isolated REM …

• CLINICAL_TRIALS research · 2026-02-17
  Clinical Trial Update: Assessment of Trunk Control and Postural Instability in Patients With Various Neurological Disorders (Stroke, Parkinson, Sclerosis Multiplex) Using Objective Tools (TecnoBody ProKin Posturometry, 3D Motion Analysis) [NA]

  Clinical trial update evaluating trunk control and postural instability in patients with stroke, Parkinson's disease, and multiple sclerosis…

• CLINICAL_TRIALS research · 2026-02-17
  Clinical Trial Update: Evaluation of the Safety of Electrical Spinal Cord Stimulation in Parkinson's Patients Presenting With Painful Camptocormia [NA]

  A clinical trial is evaluating the safety of electrical spinal cord stimulation in patients with Parkinson's disease who have painful campto…

• CLINICAL_TRIALS research · 2026-02-17
  Clinical Trial Update: Understanding Freezing of Gait Using Brain Signals and Virtual Reality [NA]

  A UCLA-led clinical trial update indicates enrollment by invitation for a study using brain signals and virtual reality to understand freezi…

• CLINICAL_TRIALS research · 2026-02-17
  Clinical Trial Update: Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment [NA]

  An ongoing Vanderbilt clinical trial investigates corticostriatal mechanisms underlying cognitive impairment in Parkinson disease. Recruitme…

• CLINICAL_TRIALS research · 2026-02-13
  Clinical Trial Update: Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease [NA]

  This clinical trial is investigating the effects of vagal nerve stimulation on leg muscle activity and posture in people with Parkinson's di…

• CLINICAL_TRIALS research · 2026-02-13
  Clinical Trial Update: Clinical Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation With Different Modes on Parkinson's Disease [NA]

  This clinical trial investigates the clinical efficacy of intermittent theta burst stimulation delivered to the primary motor cortex, using …

• CLINICAL_TRIALS research · 2026-02-13
  Clinical Trial Update: Feasibility and Preliminary Effects of the Walking Tall App for Home-Based Gait Training in Parkinson's Disease: A Pilot Study [NA]

  Pilot feasibility study of the Walking Tall app for home-based gait training in Parkinson's disease, with preliminary effects and ongoing re…

• CLINICAL_TRIALS research · 2026-02-13
  Clinical Trial Update: Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease [NA]

  This document describes a clinical trial update for a 24-hour adaptive deep brain stimulation approach in Parkinson's disease. The study is …

• CLINICAL_TRIALS research · 2026-02-13
  Clinical Trial Update: Social & QoL Behaviors in Parkinson's Disease

  This clinical trial update describes a study on social and quality-of-life behaviors in Parkinson disease that is currently recruiting, spon…

• CLINICAL_TRIALS research · 2026-02-13
  Clinical Trial Update: Neurophysiology of Reward Signaling in Parkinson's Disease [NA]

  This clinical trial update notes that Vanderbilt University Medical Center is recruiting participants for a study on neurophysiology of rewa…

• CLINICAL_TRIALS research · 2026-02-12
  Clinical Trial Update: Clinical Validity of the DANU Sports System for Gait and Balance Assessment in Parkinson's Disease

  This document reports an ongoing clinical trial evaluating the validity of the DANU Sports System for assessing gait and balance in Parkinso…

• CLINICAL_TRIALS research · 2026-02-12
  Clinical Trial Update: Objective Mobility Assessment Using Wearable Technology for Clinical Application in Parkinson's Disease: From Validation to Fall Prediction

  An ongoing clinical trial from Northumbria University is evaluating wearable-based objective mobility assessment for Parkinson disease. The …

• CLINICAL_TRIALS research · 2026-02-12
  Clinical Trial Update: REal-life ON PARKinson's - ITaly (REONPARK-IT)

  REONPARK-IT is a clinical trial in Italy that is currently recruiting for Parkinson disease.

• CLINICAL_TRIALS research · 2026-02-12
  Clinical Trial Update: Evaluation of the Effects of Levodopa-Benserazide Drug Combination on Periodontal Status in Patients With Parkinson's Disease

  This clinical trial evaluates whether the combination of levodopa and benserazide affects periodontal status in patients with Parkinson's di…

• CLINICAL_TRIALS research · 2026-02-11
  Clinical Trial Update: Optimistic and Pessimistic Dopamine Signals in the Human Brain: a Mapping and Modelling Study in Health and Parkinson's Disease

  A clinical trial update describing a study to map and model dopamine signals in the human brain in healthy individuals and in Parkinson's di…

• CLINICAL_TRIALS research · 2026-02-11
  Clinical Trial Update: Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder

  A clinical trial is evaluating colonic tissue biopsy to detect phosphorylated alpha-synuclein as a potential diagnostic biomarker for Parkin…