Pancreatic Adenocarcinoma
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: Hyperpolarized C Pyruvate Magnetic Resonance Imaging, and Blood-Based Biomarkers for Early Detection of Pancreatic Adenocarcinoma in Patients With Intraductal Papillary Mucinous Neoplasms
A clinical trial update describing an imaging and biomarker study for early detection of pancreatic cancer in patients with intraductal papi…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: Preoperative Fractionated Radiation Therapy Versus Stereotactic Body Radiation Therapy for Resectable or Borderline Resectable, or Locally Advanced Type A Pancreatic Adenocarcinoma [NA]
A ClinicalTrials.gov listing for a study comparing preoperative fractionated radiation therapy versus stereotactic body radiation therapy in…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Radiation Therapy in Combination With Durvalumab for People With Pancreatic Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial update evaluating radiation therapy in combination with durvalumab for pancreatic adenocarcinoma; the study is cu…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Testing the Combination of Two Approved Chemotherapy Drugs and Radiation Prior to Surgery in Localized Pancreatic Cancer [Phase 2]
Phase 2 neoadjuvant trial testing the combination of two approved chemotherapy drugs with radiation before surgery for localized pancreatic …
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Safety of Combining Irinotecan With 5-FU, Leucovorin/Folinic Acid, Oxaliplatin, and Docetaxel Chemotherapies [Phase 1]
A Phase 1 clinical trial update evaluating the safety of a quadruple chemotherapy combination (irinotecan with 5-FU/leucovorin, oxaliplatin,…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Safety and Tolerance of Epigenetic and Immunomodulating Drugs Combined With Chemotherapeutics in Patients Suffering From Advanced Pancreatic Cancer [Phase 1, Phase 2]
This completed Phase 1/2 study evaluated the safety and tolerability of combining epigenetic and immunomodulating drugs with standard chemot…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: 9-ING-41 Combined With Retifanlimab, Plus Modified FOLFIRINOX for Patients With Advanced Pancreatic Adenocarcinoma (RiLEY) [Phase 1]
This Phase 1 clinical trial update describes a study of 9-ING-41 combined with retifanlimab and a modified FOLFIRINOX regimen in patients wi…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula [Phase 1, Phase 2]
A clinical trial update indicates that total pancreatectomy with islet autotransplantation (TPIAT) is being evaluated in Phase 1/2 for resec…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Patient-derived Organoids Drug Screen in Pancreatic Cancer [NA]
The study completed a patient-derived pancreatic tumor organoids drug-screen to evaluate potential drug responses.
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Maintenance Niraparib Plus Ipilimumab in Patients With Metastatic Pancreatic Adenocarcinoma Whose Disease Has Not Progressed on Platinum-Based Chemotherapy [Phase 2]
This clinical trial update describes a Phase 2 study evaluating maintenance Niraparib plus Ipilimumab in patients with metastatic pancreatic…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors [Phase 1]
Phase 1 first-in-human trial evaluating OKN4395 in combination with pembrolizumab in patients with solid tumors is currently recruiting. The…
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CLINICAL_TRIALS trial_result · 2025-08-27Clinical Trial Update: A Phase 2 Trial of High-dose Ascorbate for Pancreatic Cancer (PACMAN 2.1) [Phase 2]
Phase 2 trial evaluating high-dose vitamin C (ascorbate) for pancreatic cancer has completed (PACMAN 2.1).
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: The Future Management of Patients With Neoplasms of the Gastro-intestinal Tract [NA]
This clinical trial update describes a study on the future management of gastrointestinal tract cancers, including pancreatic adenocarcinoma…
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors [Phase 1, Phase 2]
A clinical trial update for SNS-101 (anti-VISTA) as monotherapy and in combination with cemiplimab in adults with advanced solid tumors, cur…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Study of Paclitaxel Protein Bound + Gemcitabine + Cisplatin + Hydrochloroquine as Treatment in Untreated Pancreas Cancer [Phase 2]
A Phase 2 trial evaluating a four-drug regimen (nab-paclitaxel, gemcitabine, cisplatin, and hydroxychloroquine) in untreated pancreatic aden…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: Genetic Testing Decision Aid [NA]
This clinical trial update reports a genetic testing decision aid study sponsored by Massachusetts General Hospital. It targets patients wit…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Stereotactic Body Radiation Therapy for Inoperable Non-metastasized Pancreatic Adenocarcinoma [NA]
A clinical trial is evaluating stereotactic body radiation therapy for patients with non-metastasized unresectable pancreatic adenocarcinoma…
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: Cisplatin to Patients With Pancreatic Cancer and Homologous Recombination Deficiency [Phase 2, Phase 3]
This update indicates that cisplatin is being studied in patients with pancreatic adenocarcinoma who have homologous recombination deficienc…
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Vitamin C to Chemotherapy Related Anemia in Pancreatic Cancer [Phase 3]
Phase 3 trial update evaluating vitamin C to treat chemotherapy-related anemia in metastatic pancreatic adenocarcinoma; the study is current…
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: mFOLFIRINOX Plus Radiotherapy to Patients With CA19-9-normal Advanced Pancreatic Cancer [Phase 2]
A Phase 2 trial investigating the addition of radiotherapy to the modified FOLFIRINOX chemotherapy regimen in CA19-9-normal advanced pancrea…
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: Radiotherapy to Patients With CA19-9-elevated Advanced Pancreatic Cancer [Phase 3]
Phase 3 clinical trial evaluating radiotherapy for CA19-9–elevated advanced pancreatic cancer; the study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: Is the 3D-PANC MSP Model Superior to CT for Assessing Response to Neoadjuvant Treatment in PCA Patients?
Clinical trial update evaluating whether the 3D-PANC MSP model better assesses neoadjuvant treatment response in pancreatic adenocarcinoma t…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: CT-95 in Advanced Cancers Associated With Mesothelin Expression [Phase 1]
Phase 1 trial CT-95 for mesothelin-expressing tumors is currently recruiting across multiple indications, including epithelial ovarian cance…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: DCE MRI in Patients With Pancreatic Cancer [NA]
A terminated clinical trial evaluating dynamic contrast-enhanced MRI in patients with pancreatic cancer, including familial pancreatic cance…
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: A Study of Neoadjuvant Paricalcitol to Target the Microenvironment in Resectable Pancreatic Cancer [Phase 1]
A Phase 1 neoadjuvant trial evaluating paricalcitol to modify the tumor microenvironment in resectable pancreatic cancer has completed.