Orthostatic Hypotension
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CLINICAL_TRIALS research · 2025-08-24Clinical Trial Update: Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension
This clinical trial is investigating the mechanisms of central blood pressure regulation in patients with Parkinson disease and orthostatic …
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: Blood Pressure Effects on Cognition and Brain Blood Flow in PD [NA]
University of California, San Diego is conducting a clinical trial to evaluate the effects of blood pressure on cognition and brain blood fl…
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CLINICAL_TRIALS research · 2025-07-14Clinical Trial Update: Droxidopa / Pyridostigmine in Orthostatic Hypotension [Phase 2]
Clinical trial update for a Phase 2 study evaluating droxidopa and pyridostigmine in orthostatic hypotension, currently enrolling by invitat…
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms [NA]
This clinical trial update describes a Vanderbilt-led study evaluating accelerometer-based quantification of symptoms in neurogenic orthosta…
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FDA approval · 2025-05-08FDA Approved: MIDODRINE HYDROCHLORIDE — Supplemental Application (Lifestar Pharma LLC)
FDA approved a supplemental application for midodrine hydrochloride (generic) by Lifestar Pharma LLC.
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CLINICAL_TRIALS research · 2025-05-08Clinical Trial Update: Speed of Robotic Leg Movements and Orthostatic Hypotension in Subacute SCI [NA]
A clinical trial investigating the speed of robotic leg movements and orthostatic hypotension in subacute spinal cord injury; the study is c…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury [Phase 4]
Phase 4 trial evaluating the dose-response of droxidopa for orthostatic hypotension in individuals with spinal cord injury; results posted i…
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CLINICAL_TRIALS trial_result · 2025-02-21Clinical Trial Update: Treatment of Post-SCI Hypotension [Phase 2, Phase 3]
The document reports completion of Phase 2 and Phase 3 clinical trials investigating treatment for post-spinal cord injury hypotension. Resu…
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: RAAS and Arterial Stiffness in SCI
This completed trial investigated the relationship between the renin-angiotensin-aldosterone system and arterial stiffness in individuals wi…
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CLINICAL_TRIALS research · 2025-01-29Clinical Trial Update: Frequency of Orthostatic Hypotension in Patients Who Underwent Colonoscopy
An Ankara University-sponsored clinical trial is studying the frequency of orthostatic hypotension in patients after colonoscopy, and the st…
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CLINICAL_TRIALS research · 2024-12-19Clinical Trial Update: The Value of Near-infrared Spectroscopy and Blood Pressure Measurements in Estimating Future Fall Risk in Older Adults
This clinical trial update describes a study evaluating near-infrared spectroscopy and blood pressure measurements to estimate future fall r…
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CLINICAL_TRIALS research · 2024-12-09Clinical Trial Update: Hypercapnia in Orthostatic Hypotension [NA]
A University of Calgary-sponsored clinical trial is investigating hypercapnia in patients with orthostatic hypotension and neurogenic orthos…
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease [Phase 2, Phase 3]
A Phase 2/3 clinical trial assessed the effect of levodopa on cardiovascular autonomic function in Parkinson disease, including patients wit…
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CLINICAL_TRIALS withdrawal · 2024-10-17Clinical Trial Update: Controlling Orthostatic Hypotension in People with Cervical Spinal Cord Injury [NA]
A clinical trial evaluating methods to control orthostatic hypotension in individuals with cervical spinal cord injury has been withdrawn.
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CLINICAL_TRIALS research · 2024-10-01Clinical Trial Update: Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury [NA]
This clinical trial update reports ongoing recruitment for a study examining the autonomic effects of spinal cord stimulation in individuals…
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: Treatment of Orthostatic Hypotension in SCI [Phase 4]
A Phase 4 clinical trial sponsored by the James J. Peters Veterans Affairs Medical Center is recruiting to evaluate treatment for orthostati…
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CLINICAL_TRIALS trial_result · 2024-07-18Clinical Trial Update: Effects of Blueberries in Older Adults [NA]
A completed clinical trial evaluated the effects of blueberry consumption on blood pressure and related vascular measures in older adults.
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CLINICAL_TRIALS trial_result · 2024-07-17Clinical Trial Update: Assessment of the Mechanism of Non-cardiac Syncope
A completed clinical trial provides an update on the mechanisms underlying non-cardiac syncope.
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CLINICAL_TRIALS research · 2024-07-10Clinical Trial Update: SalT Supplementation in Older Adults With Orthostatic Intolerance Disorders [Phase 2]
A Phase 2 clinical trial evaluating salt supplementation (sodium chloride) in older adults with orthostatic hypotension is currently recruit…
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CLINICAL_TRIALS trial_result · 2024-06-05Clinical Trial Update: The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
The completed trial evaluates how medication-induced blood pressure reduction affects cerebral hemodynamics in hypertensive, frail older adu…
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CLINICAL_TRIALS trial_result · 2024-01-05Clinical Trial Update: Efficacy, Safety and Response Predictors of Adjuvant Astragalus for Cognition in Orthostatic Hypotension [Phase 2]
Phase 2 clinical trial update evaluating efficacy, safety, and response predictors of adjuvant astragalus for cognition in orthostatic hypot…
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FDA approval · 2023-11-01FDA Approved: MIDODRINE HYDROCHLORIDE — Original Application (Lifestar Pharma LLC)
FDA approved the original abbreviated new drug application for midodrine hydrochloride, a generic version manufactured by Lifestar Pharma LL…
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FDA approval · 2023-10-17FDA Approved: MIDODRINE HYDROCHLORIDE — Original Application (Novugen Pharma (USA) LLC)
FDA approved the original abbreviated new drug application for midodrine hydrochloride, enabling a generic version of the medication.
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CLINICAL_TRIALS trial_result · 2022-09-26Clinical Trial Update: TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) [Phase 2]
Phase 2 clinical trial update for TD-9855 in neurogenic orthostatic hypotension (nOH) completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-09-26Clinical Trial Update: Lundbeck TOMs Orthostatic Hypotension [Phase 4]
A Phase 4 trial update for Lundbeck TOMs addressing orthostatic hypotension in patients with idiopathic Parkinson disease; study completed w…