Opioid Withdrawal
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-06-09Clinical Trial Results: An Innovative Intervention for OUD Treatment [Phase 2, Phase 3]
Phase 2 and Phase 3 clinical trial results for a new intervention in opioid use disorder treatment have been completed, with results posted.
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CLINICAL_TRIALS trial_result · 2026-06-09Clinical Trial Update: An Innovative Intervention for OUD Treatment [Phase 2, Phase 3]
Phase 2/3 clinical trial update for an innovative intervention targeting opioid-related disorders, completed with results posted.
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: Sublingual Dexmedetomidine for Treating Opioid Withdrawal [Phase 1, Phase 2]
Clinical trial update shows Phase 1/2 evaluation of sublingual dexmedetomidine for opioid withdrawal. The study is currently active but not …
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
Spark Biomedical, Inc. is recruiting for a study aimed at sensing physiological symptoms of opioid withdrawal and cravings in patients with …
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder [NA]
The Sparrow Link Neuromodulation Device is being studied for managing opioid withdrawal in hospitalized adults with opioid use disorder, and…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3 [Phase 3]
Phase 3 clinical trial evaluating non-invasive vagal nerve stimulation for opioid use disorder is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: CEDRN: Opioid Registry
This ClinicalTrials.gov entry describes the CEDRN Opioid Registry, a research study led by the University of British Columbia, currently rec…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal [Phase 2]
A Phase 2 clinical trial evaluating the combination of pregabalin and lofexidine for outpatient treatment of opioid withdrawal is currently …
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Evaluating Buspirone to Treat Opioid Withdrawal [Phase 2]
An ongoing Phase 2 study at Johns Hopkins is evaluating buspirone for treating opioid withdrawal symptoms in people with opioid use disorder…
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CLINICAL_TRIALS research · 2025-11-05Clinical Trial Update: ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating adding buprenorphine, cognitive-behavioral therapy (CBT), and transcranial magnetic stimulation (TM…
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FDA approval · 2025-10-22FDA Approved: LOFEXIDINE — Original Application (ANI Pharmaceuticals, Inc.)
FDA approved ANI Pharmaceuticals, Inc.'s original Abbreviated New Drug Application to market a generic lofexidine product.
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD [Phase 2, Phase 3]
A Phase 2/3 trial evaluating pramipexole for restless legs symptoms to improve outcomes during protracted opioid withdrawal in opioid use di…
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CLINICAL_TRIALS withdrawal · 2025-08-01Clinical Trial Update: A Pharmacokinetic, Safety, and Tolerability Study of LUCEMYRA in the Treatment of Opioid Withdrawal Management in Adolescent Subjects [Phase 1]
A Phase 1 study evaluating LUCEMYRA (lofexidine) for opioid withdrawal management in adolescent subjects has been withdrawn.
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CLINICAL_TRIALS trial_result · 2025-07-04Clinical Trial Update: Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder [NA]
This clinical trial update indicates that a study of transcutaneous auricular neurostimulation for relapse prevention in opioid use disorder…
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CLINICAL_TRIALS research · 2025-06-10Clinical Trial Update: Understanding the Effects of Transcutaneous Auricular Neurostimulation for Treatment of Chronic Pain [NA]
A clinical trial is evaluating transcutaneous auricular neurostimulation for chronic pain, with potential relevance to opioid withdrawal and…
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CLINICAL_TRIALS trial_result · 2024-10-21Clinical Trial Update: Randomized, Double-Blind, Placebo-Controlled Pilot Study on the Safety and Effectiveness of LUCEMYRA During an Opioid Taper in Treatment of Withdrawal [Phase 2]
A Phase 2 randomized, double-blind, placebo-controlled pilot study evaluating LUCEMYRA (lofexidine) during opioid taper in withdrawal was te…
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FDA approval · 2024-09-05FDA Approved: LUCEMYRA — Supplemental Application (USWM, LLC)
The FDA approved a supplemental NDA for Lucemyra (lofexidine hydrochloride) submitted by US WorldMeds, LLC.
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CLINICAL_TRIALS trial_result · 2024-05-20Clinical Trial Update: Combining Pregabalin (LYRICA®) With Lofexidine (LUCEMYRATM) to Treat OPIOID Withdrawal [Phase 2]
Phase 2 trial evaluating the combination of pregabalin (Lyrica) and lofexidine (Lucemyra) for opioid withdrawal; results were posted after c…
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CLINICAL_TRIALS trial_result · 2023-10-26Clinical Trial Update: Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal [Phase 1, Phase 2]
Clinical trial update for dexmedetomidine in treating symptoms of acute opioid withdrawal (Phase 1/2) completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-08-29Clinical Trial Update: Oral Cannabidiol for Opioid Withdrawal [Phase 1, Phase 2]
A Phase 1/2 trial evaluating oral cannabidiol for opioid withdrawal and craving has completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-08-08Clinical Trial Update: Medical Management of Sleep Disturbance During Opioid Tapering [Phase 2]
Phase 2 trial evaluating medical management of sleep disturbance during opioid tapering in opioid dependence/withdrawal.
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CLINICAL_TRIALS trial_result · 2022-02-23Clinical Trial Update: Lofexidine for Adults Undergoing Lumbar Spine Surgery [Phase 4]
Phase 4 clinical trial update on lofexidine for adults undergoing lumbar spine surgery, focusing on opioid withdrawal management; study comp…
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CLINICAL_TRIALS trial_result · 2021-07-06Clinical Trial Update: High Dosage Buprenorphine as a Drug Strategy Withdrawal Assistance of Analgesics Opioid [Phase 2]
A Phase 2 clinical trial investigating high dosage buprenorphine for withdrawal assistance in analgesic opioid use.
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CLINICAL_TRIALS trial_result · 2021-04-26Clinical Trial Update: Open-Label, Safety Study of Lofexidine [Phase 3]
Open-label safety study of lofexidine in opioid withdrawal completed; results posted in 2021.
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CLINICAL_TRIALS trial_result · 2020-04-07Clinical Trial Update: Pregabalin for Opiate Withdrawal Syndrome [Phase 4]
Phase 4 clinical trial assessing pregabalin for opioid withdrawal; study completed.