Nonalcoholic Steatohepatitis
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CLINICAL_TRIALS trial_result · 2024-07-09Clinical Trial Update: A Clinical Trial of BGT-002 Tablets in Subjects With Nonalcoholic Steatohepatitis [Phase 1, Phase 2]
A Phase 1/2 trial evaluating BGT-002 tablets for nonalcoholic steatohepatitis has completed.
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: Pentoxifylline in Treatment of Patients With Nonalcoholic Steatohepatitis [Phase 3]
Phase 3 clinical trial evaluating pentoxifylline for nonalcoholic steatohepatitis has completed, according to the trial registry update.
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CLINICAL_TRIALS research · 2024-06-18Clinical Trial Update: Safety of DNP007 in Healthy Subjects [Phase 1]
Phase 1 trial evaluating the safety of DNP007 in healthy subjects, with listed conditions including liver transplant rejection, complication…
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CLINICAL_TRIALS trial_result · 2024-06-14Clinical Trial Update: A Study to Assess the Efficacy and Safety of VK2809 for 52 Weeks in Subjects With Biopsy Proven NASH [Phase 2]
The document reports the completion of a Phase 2 trial evaluating the efficacy and safety of VK2809 in adults with biopsy-confirmed nonalcoh…
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CLINICAL_TRIALS trial_result · 2024-06-07Clinical Trial Update: AVIATION Study: A Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of TERN-201 in Patients With Non-Cirrhotic Non-Alcoholic Steatohepatitis [Phase 1]
Phase 1 AVIATION trial evaluating safety, pharmacokinetics/pharmacodynamics and preliminary efficacy of TERN-201 in noncirrhotic nonalcoholi…
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CLINICAL_TRIALS research · 2024-05-29Clinical Trial Update: Precise Evaluation Criteria for Histological Regression of NASH Fibrosis
This clinical trial update from Beijing Friendship Hospital describes precise criteria for histological assessment of regression in NASH-rel…
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CLINICAL_TRIALS trial_result · 2024-05-28Clinical Trial Update: A Phase II Clinical Trial of Chiglitazar for NASH [Phase 2]
A Phase II trial of chiglitazar for nonalcoholic steatohepatitis has completed. The study was sponsored by Chipscreen Biosciences, Ltd.
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CLINICAL_TRIALS trial_result · 2024-05-24Clinical Trial Update: Aspirin for the Treatment of Nonalcoholic Fatty Liver Disease [Phase 1, Phase 2]
Aspirin is being studied for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Phase 1/2. The trial is completed, and res…
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CLINICAL_TRIALS research · 2024-05-22Clinical Trial Update: Early Liver Disease Breath Detection
Owlstone Ltd reports an early-stage trial update evaluating breath-based detection for liver disease, including liver fibrosis and nonalcoho…
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CLINICAL_TRIALS research · 2024-05-22Clinical Trial Update: Clinical Study Evaluating the Safety and Efficacy of Esomeprazole in Treatment of Non-alcoholic Steatohepatitis [Phase 1, Phase 2]
Clinical trial evaluating the safety and efficacy of esomeprazole for non-alcoholic fatty liver disease and nonalcoholic steatohepatitis is …
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CLINICAL_TRIALS trial_result · 2024-05-17Clinical Trial Update: A Study of ALN-HSD in Healthy Adult Subjects and Adult Patients With Nonalcoholic Steatohepatitis (NASH) [Phase 1]
This clinical trial update reports termination of a Phase 1 study of ALN-HSD in healthy adult subjects and adults with nonalcoholic steatohe…
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CLINICAL_TRIALS research · 2024-05-03Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Rencofilstat in Subjects With NASH and Advanced Liver Fibrosis [Phase 2]
A Phase 2 clinical trial update evaluating the efficacy and safety of Rencofilstat in subjects with nonalcoholic steatohepatitis and advance…
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CLINICAL_TRIALS trial_result · 2024-04-29Clinical Trial Update: A Study of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-3655-001) [Phase 2]
A Phase 2 study of MK-3655 for pre-cirrhotic Nonalcoholic Steatohepatitis was terminated, and results have been posted.
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CLINICAL_TRIALS trial_result · 2024-04-02Clinical Trial Update: A Multiple Ascending Dose Study of Pegozafermin in Participants With Biopsy Confirmed Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) and at High Risk of NASH [Phase 1, Phase 2]
A multiple ascending dose study of pegozafermin in participants with biopsy-confirmed NASH or NAFLD at high risk of NASH has completed phase…
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CLINICAL_TRIALS trial_result · 2024-03-29Clinical Trial Update: A Study of Oral Insulin to Reduce Liver Fat Content in Type 2 Diabetes Patients With Nonalcoholic Steatohepatitis (NASH) [Phase 2]
Phase 2 study evaluating oral insulin to reduce liver fat in type 2 diabetes patients with nonalcoholic steatohepatitis has completed with r…
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CLINICAL_TRIALS trial_result · 2024-03-29Clinical Trial Update: Dapagliflozin Efficacy and Action in NASH [Phase 3]
Phase 3 clinical trial update evaluating dapagliflozin for efficacy and action in nonalcoholic steatohepatitis (NASH) completed.
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CLINICAL_TRIALS trial_result · 2024-03-28Clinical Trial Update: Study to Evaluate MET642 in Patients With NASH [Phase 2]
Phase 2 trial update for MET642 in nonalcoholic steatohepatitis (NASH) has completed.
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FDA approval · 2024-03-14FDA Approved: REZDIFFRA — Original Application (Madrigal Pharmaceuticals, Inc.)
FDA approved REZDIFFRA (resmetirom) from Madrigal Pharmaceuticals for the treatment of nonalcoholic steatohepatitis with fibrosis in adults.
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CLINICAL_TRIALS trial_result · 2024-03-01Clinical Trial Update: Phase 2a Study of HU6 in Subjects With Elevated Liver Fat and High BMI Volunteers [Phase 2]
Phase 2a study of HU6 in subjects with elevated liver fat and high BMI related to nonalcoholic steatohepatitis (NASH) has completed with res…
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CLINICAL_TRIALS trial_result · 2024-02-20Clinical Trial Update: A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis [Phase 3]
Phase 3 study evaluating efficacy and safety of MGL-3196 (Resmetirom) in patients with NASH and fibrosis is active but not recruiting.
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CLINICAL_TRIALS trial_result · 2024-02-20Clinical Trial Update: Norursodeoxycholic Acid vs. Placebo in NASH [Phase 2]
Phase 2 trial update for Norursodeoxycholic Acid versus placebo in nonalcoholic steatohepatitis is in an unknown status.
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CLINICAL_TRIALS trial_result · 2023-12-26Clinical Trial Update: Efficacy, Safety and Tolerability of the Combination of Tropifexor & Licogliflozin and Each Monotherapy, Compared With Placebo in Adult Patients With NASH and Liver Fibrosis. [Phase 2]
Phase 2 study evaluating the efficacy, safety and tolerability of the combination of Tropifexor and Licogliflozin, as well as each monothera…
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CLINICAL_TRIALS trial_result · 2023-12-14Clinical Trial Update: The Efficacy, Safety and Tolerability of Oral LPCN 1144 in Subjects With Nonalcoholic Steatohepatitis [Phase 2]
Phase 2 trial update for oral LPCN 1144 in nonalcoholic steatohepatitis (NASH) has completed with posted results.
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CLINICAL_TRIALS trial_result · 2023-11-21Clinical Trial Update: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of CS0159 in Subjects With NASH [Phase 2]
Phase 2 trial assessing CS0159 in nonalcoholic steatohepatitis (NASH) has completed.
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CLINICAL_TRIALS trial_result · 2023-11-15Clinical Trial Update: A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001) [Phase 2]
Phase 2 clinical trial of efinopegdutide (MK-6024) in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis has completed with r…