Non-muscle Invasive Bladder Cancer
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: Urine-based Molecular Testing vs Cystoscopy for Surveillance of Nonmuscle Invasive Bladder Cancer (NMIBC)
A Mayo Clinic-sponsored clinical trial comparing urine-based molecular testing to cystoscopy for surveillance in non-muscle invasive bladder…
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer [Phase 3]
Pfizer's Phase 3 trial of sasanlimab in non-muscle invasive bladder cancer has posted results and the study is currently listed as active bu…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Phase II Prospective Cohort Study of Intravesical Recombinant Human Type 5 Adenovirus Injection for Treatment of High-Risk Non-Muscle Invasive Bladder Cancer: Evaluating Efficacy and Safety [Phase 2]
Phase II prospective cohort study evaluating intravesical recombinant human adenovirus type 5 injection for high-risk non-muscle invasive bl…
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CLINICAL_TRIALS trial_result · 2026-01-16Clinical Trial Update: Comparison of Pathological Outcome and Recurrence Rate Between En Bloc and Conventional Transurethral Resection of Bladder Tumor [NA]
A completed clinical trial comparing en bloc versus conventional transurethral resection of bladder tumors evaluating pathological outcomes …
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CLINICAL_TRIALS trial_result · 2026-01-16Clinical Trial Update: En Bloc Transurethral Resection of Non-muscle Invasive Bladder Cancer [NA]
The document notes the completion of a clinical trial evaluating en bloc transurethral resection for non-muscle invasive bladder cancer.
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: A Phase 3 Study of UGN-103 for Treatment of Patients With Low-grade Intermediate-risk Non-muscle Invasive Bladder Cancer [Phase 3]
This entry reports a Phase 3 trial of UGN-103 for low-grade, intermediate-risk non-muscle invasive bladder cancer and indicates the study is…
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: A Phase 1 Dose-escalation Study of UGN-301 in Patients With Recurrent Non-muscle Invasive Bladder Cancer (NMIBC) [Phase 1]
A Phase 1 dose-escalation study of UGN-301 in patients with recurrent non-muscle invasive bladder cancer has been completed.
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Supporting Sexual Health in Bladder Cancer Patients: A Sequential Mixed-Methods Intervention Study [NA]
A sequential mixed-methods intervention trial to support sexual health in bladder cancer patients, currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations [Phase 1, Phase 2]
Early-phase clinical update on TYRA-300 showing safety signals and preliminary anti-tumor activity in locally advanced or metastatic urothel…
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CLINICAL_TRIALS other · 2026-01-12Clinical Trial Update: A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBT [Phase 3]
Phase 3 trial evaluating adjuvant Cretostimogene Grenadanorepvec for intermediate-risk non-muscle invasive bladder cancer after TURBT is cur…
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CLINICAL_TRIALS trial_result · 2026-01-07Clinical Trial Update: Assessment of Safety, Tolerability, Radiation Dosimetry, Imaging Properties of 89Zr-girentuximab in Patients With NMIBC [EARLY_Phase 1]
Early-phase study evaluating safety, tolerability, radiation dosimetry, and imaging properties of 89Zr-labeled girentuximab in patients with…
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CLINICAL_TRIALS trial_result · 2025-12-31Clinical Trial Update: Vesical Imaging-Reporting and Data System (VI-RADS) Followed by Photodynamic Trans-urethral Resection of Bladder Tumours (PDD-TURBT) to Avoid Secondary Resections (Re-TURBT) in Non-Muscle Invasive Bladder Cancers (NMIBCs) [Phase 4]
This Phase 4 trial is assessing whether VI-RADS imaging followed by photodynamic TURBT (PDD-TURBT) can avoid secondary resections in non-mus…
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CLINICAL_TRIALS trial_result · 2025-12-29Clinical Trial Update: Implications of Post-Operative Irrigation Fluid's Osmolarity on the Recurrence of Non-Muscle Invasive Bladder Cancer Following Transurethral Resection [Phase 2, Phase 3]
A completed Phase 2/3 trial from Ain Shams University investigated whether the osmolarity of postoperative irrigation fluids influences the …
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676) [Phase 3]
This entry describes a phase 3 clinical trial (MK-3475-676/KEYNOTE-676) evaluating pembrolizumab in combination with intravesical Bacillus C…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: A Phase II Trial of Bicalutamide in Patients Receiving Intravesical BCG for Non-muscle Invasive Bladder Cancer [Phase 2]
A Phase II trial of bicalutamide in patients receiving intravesical BCG for non-muscle invasive bladder cancer is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Sarcopenia and NMIBC Prognosis Study
A clinical trial update for a study examining the prognostic impact of sarcopenia in non-muscle invasive bladder cancer. The study is not ye…
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EMA approval · 2025-12-12New medicine to treat non-muscle invasive bladder cancer
The EMA announced approval of a new medicine, Anktiva (bempegaldesleukin), for non-muscle invasive bladder cancer that does not respond to B…
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: A Phase III Randomised Control Clinical Trial of Radiotherapy With Radiosensitisation Versus Intravesical Bacillus Calmette-Guerin Therapy for High-risk Non-muscle Invasive Bladder Cancer. [Phase 3]
A Phase III randomized trial compares radiotherapy with radiosensitisation versus intravesical Bacillus Calmette-Guérin therapy for high-ris…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Intravesical Adoptive Cell Therapy w/ TIL for BCG Exposed High Grade NMIBC [Phase 1]
Phase 1 clinical trial evaluating intravesical adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) for BCG-exposed high-grade n…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: Evaluation of Safety, Tolerability and Response of ATO-101™ in Patients With Non-Muscle-Invasive Bladder Cancer (PERSEVERANCE EU) [Phase 1]
Phase 1 trial evaluating the safety, tolerability, and anti-tumor activity of ATO-101 in patients with non-muscle-invasive bladder cancer. T…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: The Role of Universal Cancer Only Marker SIX6 in Diagnosing Non-Muscle Invasive Bladder Cancer [NA]
This clinical trial update reports on investigating SIX6 as a universal cancer biomarker for diagnosing non-muscle invasive bladder cancer, …
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients [Phase 2]
Phase 2 clinical trial update on intravesical photodynamic therapy for non-muscle invasive bladder cancer patients unresponsive or intoleran…
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CLINICAL_TRIALS trial_result · 2025-11-21Clinical Trial Update: Study of Pembrolizumab (MK-3475) and Pembrolizumab With Other Investigational Agents in Participants With High Risk Non-muscle Invasive Bladder Cancer (MK-3475-057/KEYNOTE-057) [Phase 2]
A Phase 2 clinical trial evaluating pembrolizumab, alone or with other investigational agents, in participants with high-risk non-muscle inv…
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CLINICAL_TRIALS trial_result · 2025-11-21Clinical Trial Update: Assessement of the Concordance of Genomic Alterations Between Urine and Tissue in High-Risk NMIBC Patients
This clinical trial evaluated the concordance of genomic alterations between urine and tissue in high-risk non-muscle-invasive bladder cance…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Hyperthermic Intravesical Chemotherapy (HIVEC) in BCG-Non-Responsive High-Grade NMIBC Patients [NA]
A clinical trial update describing Hyperthermic Intravesical Chemotherapy (HIVEC) for high-grade non-muscle invasive bladder cancer that is …