Neuroblastoma
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CLINICAL_TRIALS withdrawal · 2017-08-30Clinical Trial Update: A Combined Cell Therapy Approach to the Treatment of Neuroblastoma [Phase 1]
A Phase 1 clinical trial evaluating a combined cell therapy for neuroblastoma has been withdrawn. The sponsor is H. Lee Moffitt Cancer Cente…
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CLINICAL_TRIALS withdrawal · 2017-08-25Clinical Trial Update: Dosimetry Guided PRRT With 90Y-DOTATOC [Phase 2]
A Phase 2 trial evaluating dosimetry-guided peptide receptor radionuclide therapy using 90Y-DOTATOC has been withdrawn. The study covered ne…
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CLINICAL_TRIALS trial_result · 2017-08-17Clinical Trial Update: A Phase I Trial Of The Humanized Anti-GD2 Antibody In Children And Adolescents With Neuroblastoma, Osteosarcoma, Ewing Sarcoma and Melanoma [Phase 1]
A Phase I trial of a humanized anti-GD2 antibody in children and adolescents with neuroblastoma, osteosarcoma, Ewing sarcoma, and melanoma h…
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CLINICAL_TRIALS trial_result · 2017-07-06Clinical Trial Update: Study of Irinotecan and Bortezomib in Children With Recurrent/Refractory Neuroblastoma [Phase 1]
A Phase 1 study evaluating irinotecan in combination with bortezomib in children with recurrent or refractory neuroblastoma has been complet…
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CLINICAL_TRIALS guidance · 2017-07-02Clinical Trial Update: Informed Consent in Pediatric Cancer Trials
NCI provides guidance on informed consent practices for pediatric cancer clinical trials, highlighting considerations to protect children an…
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: A Phase I Study of Vorinostat and Bortezomib in Children With Refractory of Recurrent Solid Tumors, Including CNS Tumors and Lymphomas [Phase 1]
This Phase I trial evaluated the combination of vorinostat and bortezomib in pediatric patients with refractory or recurrent solid tumors, i…
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CLINICAL_TRIALS withdrawal · 2017-07-02Clinical Trial Update: A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors [Phase 1]
A Phase I study of pazopanib as a single agent for children with refractory solid tumors has been withdrawn from the trial program.
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CLINICAL_TRIALS trial_result · 2017-06-27Clinical Trial Update: Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma [Phase 3]
A Phase 3 trial comparing combination chemotherapy and surgery with or without isotretinoin in young patients with neuroblastoma has complet…
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CLINICAL_TRIALS trial_result · 2017-06-27Clinical Trial Update: Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma [Phase 3]
Phase 3 trial comparing two myeloablation regimens in pediatric high-risk neuroblastoma patients undergoing stem cell transplant; trial comp…
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CLINICAL_TRIALS withdrawal · 2017-06-14Clinical Trial Update: 3RD GENERATION GD2 SPECIFIC CHIMERIC ANTIGEN RECEPTOR TRANSDUCED AUTOLOGOUS NATURAL KILLER T-CELLS FOR NEUROBLASTOMA [Phase 1]
The Phase 1 trial evaluating third-generation GD2-targeted CAR-NKT cell therapy for neuroblastoma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2017-06-05Clinical Trial Update: Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia [Phase 2]
Phase 2 clinical trial update evaluating alisertib in pediatric patients with various recurrent or refractory solid tumors and leukemia; stu…
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CLINICAL_TRIALS trial_result · 2017-06-01Clinical Trial Update: Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy [Phase 3]
Phase 3 trial evaluating sodium thiosulfate to prevent cisplatin-induced hearing loss in young patients with various pediatric cancers; stud…
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CLINICAL_TRIALS trial_result · 2017-05-16Clinical Trial Update: A Combined Study in Pediatric Cancer Patients for Dose Ranging and Efficacy/Safety of Plerixafor Plus Standard Regimens for Mobilization Versus Standard Regimens Alone [Phase 1, Phase 2]
Phase 1/2 pediatric trial evaluating dose-ranging and the efficacy/safety of adding plerixafor to standard mobilization regimens versus stan…
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: Decitabine Followed by a Cancer Antigen Vaccine for Patients With Neuroblastoma and Sarcoma [Phase 1]
A Phase 1 trial evaluating decitabine followed by a cancer antigen vaccine in neuroblastoma and various sarcomas has completed.
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CLINICAL_TRIALS research · 2017-05-09Clinical Trial Update: Blood Samples From Patients on a Clinical Trial to CINV During HSCT
This is an update on a clinical trial involving collection of blood samples from patients undergoing chemotherapy-induced nausea and vomitin…
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant [Phase 3]
A Phase 3 trial of moxifloxacin to prevent bacterial infections in patients who have undergone a donor stem cell transplant was terminated.
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EMA withdrawal · 2017-04-28EMA Withdrawn: Unituxin (Dinutuximab) — United Therapeutics Europe Ltd
EMA has withdrawn Unituxin (dinutuximab) from the market in Europe.
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CLINICAL_TRIALS research · 2017-04-06Clinical Trial Update: Monitor Response to Treatment in Neuroblastoma Using 3&Apos;-Deoxy-3&Apos;-Fluorothymidine- Positron Emission Tomography (FLT-PET) [NA]
This entry notes an ongoing clinical trial evaluating FLT-PET imaging to monitor treatment response in neuroblastoma. The study status is cu…
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CLINICAL_TRIALS trial_result · 2017-03-29Clinical Trial Update: Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma [Phase 3]
A Phase 3 trial evaluating isotretinoin with or without dinutuximab, aldesleukin, and sargramostim after stem cell transplant in patients wi…
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CLINICAL_TRIALS trial_result · 2017-03-16Clinical Trial Update: N2007-01: Ultratrace™ Iobenguane I 131 in Patients With Relapsed/Refractory High-Risk Neuroblastoma [Phase 2]
Phase 2 trial of Ultratrace™ Iobenguane I 131 in relapsed/refractory high-risk neuroblastoma has completed with results posted.
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CLINICAL_TRIALS research · 2017-03-14Clinical Trial Update: Study Evaluating the Efficacy and Safety With CAR-T for Relapsed or Refractory Neuroblastoma in Children [NA]
This document reports a clinical trial evaluating the efficacy and safety of CAR-T therapy in children with relapsed or refractory neuroblas…
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CLINICAL_TRIALS trial_result · 2017-03-13Clinical Trial Update: Surgery in Treating Children With Neuroblastoma [Phase 3]
A Phase 3 trial evaluating surgical treatment for pediatric neuroblastoma has completed. The update provides no results in the snippet.
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CLINICAL_TRIALS trial_result · 2017-03-03Clinical Trial Update: A Phase II Study of Pertuzumab and Erlotinib for Metastatic or Unresectable Neuroendocrine Tumors [Phase 2]
Phase II study of pertuzumab in combination with erlotinib for metastatic or unresectable neuroendocrine tumors was terminated, with results…
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FDA approval · 2017-03-01FDA Approved: UNITUXIN — Supplemental Application (United Therapeutics Corporation)
FDA approved a supplemental application for UNITUXIN (dinutuximab) submitted by United Therapeutics Corporation.
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CLINICAL_TRIALS trial_result · 2017-03-01Clinical Trial Update: Tumor Detection Using Iodine-131-Labeled Monoclonal Antibody 8H9 [NA]
A terminated clinical trial evaluating an iodine-131–labeled monoclonal antibody (8H9) for central nervous system cancers and neuroblastoma …