Myelofibrosis
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CLINICAL_TRIALS trial_result · 2022-07-07Clinical Trial Update: A New Prognostic Stratification-based Safety and Efficacy Study of Ruxolitinib in Myelofibrosis [Phase 4]
A Phase 4 clinical trial update evaluating safety and efficacy of ruxolitinib in myelofibrosis using a prognostic-stratification approach.
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CLINICAL_TRIALS trial_result · 2022-06-15Clinical Trial Update: Post Transplant Cyclophosphamide (Cytoxan) for GvHD Prophylaxis [Phase 2]
Phase 2 clinical trial update on post-transplant cyclophosphamide for graft-versus-host disease prophylaxis completed; results posted in 202…
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CLINICAL_TRIALS trial_result · 2022-06-01Clinical Trial Update: Phase 2 Study: An Open-Label, Randomized, Phase 2 Dose-Finding Study of Pacritinib in Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post- Essential Thrombocythemia Myelofibrosis Previously Treated With Ruxolitinib [Phase 2]
Phase 2 dose-finding study of pacritinib in myelofibrosis patients previously treated with ruxolitinib has completed; results posted in 2022…
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CLINICAL_TRIALS trial_result · 2022-05-09Clinical Trial Update: KRT-232 in Combination With TL-895 for the Treatment of R/R MF and KRT-232 for the Treatment of JAKi Intolerant MF [Phase 1, Phase 2]
Clinical trial update for KRT-232 in combination with TL-895 for myelofibrosis and KRT-232 for JAK inhibitor-intolerant MF, covering Phase 1…
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CLINICAL_TRIALS trial_result · 2022-05-09Clinical Trial Update: An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 Combined With Ruxolitinib in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Or Post-Essential Thrombocythemia MF (Post ET-MF) Who Have a Suboptimal Response to Ruxolitinib [Phase 1, Phase 2]
Open-label Phase 1b/2 trial evaluating KRT-232 combined with ruxolitinib in myelofibrosis patients with suboptimal response to ruxolitinib.
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CLINICAL_TRIALS trial_result · 2022-05-09Clinical Trial Update: Study of KRT-232 or TL-895 in Janus Associated Kinase Inhibitor Treatment-Naïve Myelofibrosis [Phase 2]
Phase 2 trial evaluating KRT-232 or TL-895 in JAK inhibitor–treated myelofibrosis patients remains in status unknown.
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CLINICAL_TRIALS trial_result · 2022-04-27Clinical Trial Update: A Study of Low Dose Interferon Alpha Versus Hydroxyurea in Treatment of Chronic Myeloid Neoplasms [Phase 3]
A Phase 3 trial comparing low-dose interferon alpha with hydroxyurea in chronic myeloid neoplasms has completed.
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CLINICAL_TRIALS trial_result · 2022-03-09Clinical Trial Update: Study of the JAK Inhibitor Ruxolitinib Administered Orally to Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera-Myelofibrosis (PPV-MF) or Post-Essential Thrombocythemia-Myelofibrosis (PET-MF) [Phase 1]
Phase 1 study of oral ruxolitinib in patients with primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential thrombocyt…
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CLINICAL_TRIALS trial_result · 2022-03-09Clinical Trial Update: Safety and Tolerability Study of Oral NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Vera MF or Post-essential Thrombocythemia MF [Phase 1, Phase 2]
Phase 1/2 safety and tolerability trial of oral NS-018 in myelofibrosis patients completed; results posted in 2022.
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CLINICAL_TRIALS trial_result · 2022-01-05Clinical Trial Update: A Phase 2 Study of RO7490677 In Participants With Myelofibrosis [Phase 2]
Phase 2 clinical trial update for RO7490677 in myeloproliferative neoplasms has completed; results posted in 2022.
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CLINICAL_TRIALS trial_result · 2021-11-18Clinical Trial Update: Pacritinib Versus Best Available Therapy to Treat Patients With Myelofibrosis and Thrombocytopenia [Phase 3]
Phase 3 trial comparing pacritinib to best available therapy in myelofibrosis with thrombocytopenia was terminated; results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-09-21Clinical Trial Update: Imetelstat Sodium in Treating Participants With Primary or Secondary Myelofibrosis [Phase 2]
Phase 2 trial of imetelstat sodium in adults with primary or secondary myelofibrosis has completed enrollment and results posted.
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CLINICAL_TRIALS trial_result · 2021-09-14Clinical Trial Update: Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor [Phase 2]
Phase 2 study evaluating two dose levels of imetelstat in intermediate/High-risk myelofibrosis patients previously treated with a JAK inhibi…
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CLINICAL_TRIALS trial_result · 2021-08-30Clinical Trial Update: An Open Label Study of Itacitinib Administered Orally in Patients With Myelofibrosis [Phase 2]
Open-label Phase 2 trial of itacitinib in patients with myeloproliferative neoplasms has completed.
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CLINICAL_TRIALS trial_result · 2021-08-20Clinical Trial Update: Study to Compare Busulfan-fludarabine With Thiotepa-fludarabine Regimen in Allogeneic Transplantation for Myelofibrosis [Phase 2]
Phase 2 clinical trial comparing busulfan-fludarabine versus thiotepa-fludarabine regimens in allogeneic transplantation for myelofibrosis h…
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CLINICAL_TRIALS trial_result · 2021-07-30Clinical Trial Update: A Study to Evaluate Safety and Efficacy of Panobinostat in Participants With Primary Myelofibrosis [Phase 2]
Phase 2 trial evaluating safety and efficacy of panobinostat in participants with primary myelofibrosis (terminated; results posted).
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CLINICAL_TRIALS trial_result · 2021-07-02Clinical Trial Update: A Study of Itacitinib in Combination With Low-Dose Ruxolitinib or Itacitinib Alone Following Ruxolitinib in Participants With Myelofibrosis [Phase 2]
Phase 2 trial evaluating itacitinib with low-dose ruxolitinib or itacitinib alone after ruxolitinib in myelofibrosis; trial completed with r…
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CLINICAL_TRIALS trial_result · 2021-06-21Clinical Trial Update: PD-1 Inhibition in Advanced Myeloproliferative Neoplasms [Phase 2]
Phase 2 trial assessing PD-1 inhibition in advanced myeloproliferative neoplasms has completed with results posted.
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CLINICAL_TRIALS trial_result · 2021-02-05Clinical Trial Update: Long-term Safety and Efficacy of Momelotinib in Subjects With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Polycythemia Vera or Essential Thrombocythemia [Phase 2]
Phase 2 long-term safety and efficacy update for momelotinib in various myelofibrosis subtypes; study completed with results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-01-28Clinical Trial Update: Haplo-identical Transplantation in Patients With Myelofibrosis - A Phase 2 Prospective Multicentric Prospective Study [Phase 2]
Phase 2 prospective multicenter study evaluating haplo-identical transplantation in patients with myelofibrosis.
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CLINICAL_TRIALS trial_result · 2021-01-20Clinical Trial Update: Momelotinib in Transfusion-Dependent Adults With Primary Myelofibrosis (PMF) or Post-polycythemia Vera or Post-essential Thrombocythemia Myelofibrosis (Post-PV/ET MF) [Phase 2]
Phase 2 trial update for momelotinib in transfusion-dependent adults with primary myelofibrosis and related post-PV/ET myelofibrosis; trial …
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CLINICAL_TRIALS trial_result · 2020-12-19Clinical Trial Update: Alisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia [NA]
Clinical trial update on alisertib in patients with myelofibrosis or relapsed/refractory acute megakaryoblastic leukemia (AMKL).
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CLINICAL_TRIALS trial_result · 2020-10-12Clinical Trial Update: Clinical Trial of Aplidin® in Patients With Primary Myelofibrosis [Phase 2]
Phase 2 clinical trial update for Aplidin in patients with primary myelofibrosis has completed and results posted.
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CLINICAL_TRIALS trial_result · 2020-09-29Clinical Trial Update: Pacritinib Versus Best Available Therapy to Treat Myelofibrosis [Phase 3]
Phase 3 trial comparing pacritinib to best available therapy in myelofibrosis was terminated; results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-09-10Clinical Trial Update: Myeloablative Umbilical Cord Blood Transplantation in Hematological Diseases [Phase 2]
Phase 2 trial evaluating myeloablative umbilical cord blood transplantation in various hematological diseases has completed with results pos…