Myelofibrosis
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions [Phase 3]
This Phase 3 trial compares luspatercept against placebo in patients with myeloproliferative neoplasm-associated myelofibrosis who are on JA…
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: Combination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients With Secondary Myelofibrosis [Phase 1]
Phase 1 clinical trial investigating a regimen of combination chemotherapy, total body irradiation, and donor blood stem cell transplant for…
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CLINICAL_TRIALS research · 2025-06-11Clinical Trial Update: Ropeginterferon Alfa 2b Plus Ruxolitinib for Myelofibrosis [Phase 2]
A Phase 2 clinical trial evaluating a combination of Ropeginterferon alfa-2b and ruxolitinib for myelofibrosis is currently recruiting, incl…
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CLINICAL_TRIALS research · 2025-05-30Clinical Trial Update: Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants [Phase 2]
Phase 2 clinical trial update describing the addition of itacitinib to cyclophosphamide and tacrolimus for preventing graft-versus-host dise…
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CLINICAL_TRIALS research · 2025-05-28Clinical Trial Update: Study of Tagraxofusp for Post-Transplant Maintenance for Patients With CD 123+ AML, MDS, MF and CMML (HSCT 002) [Phase 1]
An early-phase clinical trial evaluating Tagraxofusp as post-transplant maintenance in patients with CD123-positive acute myeloid leukemia, …
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: Prevalence Of Germline Gene Mutations In Patients With Myeloproliferative Neoplasms With Family History [NA]
This clinical trial update describes a study assessing the prevalence of germline gene mutations in patients with myeloproliferative neoplas…
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CLINICAL_TRIALS research · 2025-05-14Clinical Trial Update: Haplo-HSCT for Myelofibrosis [NA]
A clinical trial investigating haploidentical hematopoietic stem cell transplantation for myelofibrosis is currently recruiting.
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Allogeneic Hematopoietic Cell Transplantation With Pegylated Interferon Alfa-2a for Primary and Secondary Myelofibrosis [Phase 1]
A Phase 1 clinical trial is evaluating allogeneic hematopoietic cell transplantation with pegylated interferon alfa-2a for primary and secon…
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: Leading in MPNs Beyond Ruxolitinib in Combo With T-Regs [Phase 1]
A Phase 1 trial by Cellenkos evaluating a combination of T-regulatory cell therapy for myelofibrosis is currently recruiting.
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: A Phase II Clinical Trial of Flonoltinib Maleate Tablet in Intermediate-High Risk Myelofibrosis [Phase 2]
Phase II trial update for Flonoltinib maleate tablets in intermediate-high-risk myelofibrosis; the study is currently recruiting.
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CLINICAL_TRIALS research · 2025-04-06Clinical Trial Update: Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm [Phase 1]
Phase 1 clinical trial update for a CALR-mutant peptide vaccine in myeloproliferative neoplasms; the study is currently recruiting.
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant [EARLY_Phase 1]
An early-phase 1 clinical trial is evaluating hyperbaric oxygen therapy in combination with allogeneic peripheral blood stem cell transplant…
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CLINICAL_TRIALS research · 2025-04-02Clinical Trial Update: Role of Mesenchymal Stromal Cell Derived Extracellular Vesicles of Primary Myelofibrosis Patients on CD34+ Cells
A recruiting study evaluating the effects of extracellular vesicles derived from mesenchymal stromal cells in patients with primary myelofib…
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Ruxolitinib vs Allogeneic SCT for Patients With Myelofibrosis According to Donor Availability [Phase 2]
Phase 2 clinical trial comparing ruxolitinib to allogeneic stem cell transplantation for myelofibrosis, with enrollment guided by donor avai…
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CLINICAL_TRIALS research · 2025-03-07Clinical Trial Update: Tasquinimod in Patients with Myelofibrosis Refractory to or Intolerant for JAK2 Inhibition [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating tasquinimod in patients with myelofibrosis who are refractory to or intolerant of JAK2 inhibitors a…
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CLINICAL_TRIALS research · 2025-02-19Clinical Trial Update: 68Ga-FAPI PET/CT Imaging for Diagnosis, Grading, and Efficacy Evaluation of Myelofibrosis.
A recruiting clinical trial evaluating 68Ga-FAPI PET/CT imaging for diagnosing, grading, and evaluating efficacy in primary myelofibrosis.
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CLINICAL_TRIALS research · 2025-01-29Clinical Trial Update: Unraveling the Role of Extracellular Vesicles-driven Senescence in Myeloproliferative Neoplasms
This clinical trial investigates how extracellular vesicle–driven senescence contributes to myeloproliferative neoplasms, including essentia…
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CLINICAL_TRIALS research · 2025-01-14Clinical Trial Update: Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies [Phase 1]
This Phase 1 trial from Epigenetix, Inc. is evaluating a dual BET and CBP/p300 inhibitor across targeted advanced solid tumors and hematolog…
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CLINICAL_TRIALS research · 2024-12-05Clinical Trial Update: Ruxolitinib in Primary Myelofibrosis and Secondary to Essential Thrombocythemia or Polycythemia Vera
A recruiting clinical trial is evaluating ruxolitinib in patients with myelofibrosis, including primary myelofibrosis and myelofibrosis seco…
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CLINICAL_TRIALS research · 2024-11-06Clinical Trial Update: A Post-Marketing Surveillance Study to Assess the Safety of Fedratinib in Korean Patients With Myelofibrosis
A post-marketing surveillance study to assess the safety of fedratinib in Korean patients with myelofibrosis, currently recruiting.
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CLINICAL_TRIALS research · 2024-11-01Clinical Trial Update: Aquagenic Pruritus in Myeloproliferative Neoplasms
A completed clinical trial investigating aquagenic pruritus in patients with myeloproliferative neoplasms.
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CLINICAL_TRIALS research · 2024-08-27Clinical Trial Update: Myeloproliferative Neoplasms (MPNs) Patient Registry
An update on the Myeloproliferative Neoplasms (MPNs) Patient Registry sponsored by University Health Network in Toronto, currently recruitin…
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CLINICAL_TRIALS research · 2024-08-12Clinical Trial Update: Myeloproliferative Neoplastic Diseases Observatory From Brest
A Brest-based clinical trial observatory update for myeloproliferative neoplasms, enrolling patients with polycythemia vera, essential throm…
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CLINICAL_TRIALS research · 2024-05-10Clinical Trial Update: Study of TL-895 in Subjects With Myelofibrosis or Indolent Systemic Mastocytosis [Phase 2]
Phase 2 study of TL-895 in patients with myelofibrosis or indolent systemic mastocytosis is currently recruiting.
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CLINICAL_TRIALS research · 2024-05-03Clinical Trial Update: Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition [Phase 1]
A Phase 1 clinical trial at Fox Chase Cancer Center tests the combination of pacritinib and talazoparib in myeloproliferative neoplasms unre…