Myelofibrosis
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: Study of Stem Cell Transplant vs. Non-Transplant Therapies in High-Risk Myelofibrosis
This document reports an update on a clinical trial comparing stem cell transplantation with non-transplant therapies for patients with high…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)
This entry describes the MPN PROGRESSion Registry, an observational study to track symptoms, treatments, and disease progression in people w…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: A Study to Evaluate the Demographics and Treatment Patterns of Myelofibrosis Patients Treated With Ruxolitinib in Turkey
A completed Turkish study analyzes demographics and treatment patterns of myelofibrosis patients treated with ruxolitinib.
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: A Study of Roginolisib in Combination With Ruxolitinib in Patients With Myelofibrosis (MF) Who Are Unresponsive to JAK Inhibitors [Phase 1, Phase 2]
Clinical trial update on Roginolisib in combination with Ruxolitinib for myelofibrosis patients unresponsive to JAK inhibitors. The study is…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Clinical Trail to Evaluate the Effect of Long-term Treatment With Gecacitinib on Myelofibrosis and Gene Mutation Levels
This document is a clinical trial update describing a long-term study of Gecacitinib for myelofibrosis, including assessment of its effects …
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Elotuzumab for the Treatment of JAK2-Mutated Myelofibrosis [Phase 2]
Phase 2 clinical trial evaluating elotuzumab for JAK2-mutated myelofibrosis; the study is active but not recruiting and includes myelofibros…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: A First-in-Human, JAB-8263 in Adult Patients With Advanced Tumors [Phase 1, Phase 2]
A first-in-human Phase 1/2 trial of JAB-8263 in adults with advanced tumors is currently recruiting across multiple cancer types including l…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis [Phase 3]
Phase 3 trial update evaluating navitoclax plus ruxolitinib versus best available therapy to assess spleen volume changes in adults with rel…
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Participants With Myelofibrosis [Phase 1]
Phase 1 study evaluating the safety, pharmacokinetics, pharmacodynamics, and clinical activity of imetelstat in combination with ruxolitinib…
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: Phase I/II Clinical Trial of Axatilimab, a CSF1R Monoclonal Antibody, in Combination With Ruxolitinib as Therapy for Patients With Myelofibrosis (MF) and Chronic Myelomonocytic Leukemia (CMML) [Phase 1, Phase 2]
This Phase I/II clinical trial is evaluating Axatilimab, a CSF1R monoclonal antibody, in combination with ruxolitinib for myelofibrosis and …
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: Selumetinib and Azacitidine in High Risk Chronic Blood Cancers [Phase 1]
A Phase 1 clinical trial evaluating the combination of selumetinib and azacitidine in high-risk chronic myeloid leukemia and myelofibrosis i…
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: Clinical Epidemiology in Contemporary Patients With Myelofibrosis.
This clinical trial update describes a study on clinical epidemiology in contemporary patients with myelofibrosis and is currently recruitin…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: A Clinical Trial of TQ05105 Tablets in the Treatment of Moderate and High Risk Myelofibrosis [Phase 2]
Phase 2 study of TQ05105 tablets for moderate-to-high-risk myelofibrosis is currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) Trial [Phase 2]
A Phase 2 clinical trial called TREATMORE evaluating MethoTRExATE in myeloproliferative neoplasms is currently recruiting for polycythemia v…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes [NA]
A clinical trial is ongoing to characterize monocytes in myeloproliferative neoplasms, with recruitment currently in progress.
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: A Clinical Trial of TQ05105 Tablets Combined With TQB3617 Capsules in the Treatment of Myelofibrosis (MF) [Phase 1, Phase 2]
This clinical trial update reports a Phase 1/2 study of the combination of TQ05105 tablets and TQB3617 capsules in patients with myelofibros…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment [Phase 3]
Phase 3 clinical trial update: imetelstat is being studied versus best available therapy in intermediate-2 or high-risk myelofibrosis patien…
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Momelotinib Effectiveness in Myelofibrosis
This clinical trial update reports on the use of momelotinib for myelofibrosis, with the study currently not recruiting.
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: A Study of Ruxolitinib in Combination With Abemaciclib for the Treatment of Myelofibrosis [Phase 1]
Phase 1 clinical trial evaluating the combination of ruxolitinib and abemaciclib for myelofibrosis (including myelofibrosis associated with …
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CLINICAL_TRIALS research · 2025-10-10Clinical Trial Update: Q702 for the Treatment of Patients With Hematologic Malignancies [Phase 1]
This entry notes a Phase 1 clinical trial (Q702) for hematologic malignancies led by Mayo Clinic, currently recruiting and including histioc…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis [Phase 2]
A Phase 2 study evaluating single-agent selinexor versus physician's choice in participants with previously treated myelofibrosis; the trial…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib [Phase 3]
Phase 3 trial evaluating navtemadlin added to ruxolitinib in JAK inhibitor-naïve myelofibrosis patients with suboptimal response; currently …
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis) [Phase 1, Phase 2]
A Phase 1/2 trial is evaluating BMS-986158 alone and in combination with ruxolitinib or fedratinib in patients with myelofibrosis; the study…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: A Study of GLB-001 in Patients With Myeloid Malignancies [Phase 1]
A Phase 1 clinical trial evaluating GLB-001 in patients with myeloid malignancies is currently recruiting.
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Quantitative MRI for Myelofibrosis
A clinical trial at the University of Michigan Rogel Cancer Center is exploring quantitative MRI for myelofibrosis and is currently recruiti…