Myelofibrosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant [Phase 1]
Phase 1 clinical trial evaluating CMV-MVA Triplex Vaccine to enhance CMV-specific immunity and prevent CMV viremia in patients undergoing ha…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: CER-1236 in Patients With Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), and Myelofibrosis (MF) [Phase 1]
CERo Therapeutics is conducting a Phase 1 trial of CER-1236 for acute myeloid leukemia, myelodysplastic syndrome, and myelofibrosis; the stu…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i) [Phase 1]
Phase 1 study of AJ1-11095 in patients with primary myelofibrosis and post-polycythemia vera or post-essential thrombocythemia myelofibrosis…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Study of Canakinumab in Patients With Myelofibrosis [Phase 2]
A Phase 2 clinical trial evaluating canakinumab in patients with myelofibrosis is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Selinexor and Pacritinib in JAK Inhibitor-naïve MF Patients With Cytopenias [Phase 2]
This clinical trial update announces a Phase 2 study evaluating selinexor and pacritinib in JAK inhibitor‑naïve myelofibrosis patients with …
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms [Phase 2]
A Phase 2 clinical trial evaluating decitabine in combination with JAK inhibitors (ruxolitinib, fedratinib, or pacritinib) for accelerated o…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Gecacitinib Pre-, During- and Post-HSCT for Patients With Primary or Secondary Myelofibrosis [Phase 2]
Phase 2 clinical trial evaluating gecacitinib before, during, and after hematopoietic stem cell transplantation in patients with primary or …
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly [Phase 2]
A Phase 2 clinical trial evaluating high-dose ruxolitinib with allogeneic stem cell transplantation for patients with myelofibrosis and sple…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms [Phase 1, Phase 2]
This clinical trial aims to identify the optimal dose of N-acetylcysteine in patients with myeloproliferative neoplasms. It spans Phase 1/2 …
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Clonal Architecture of ASXL1-mutated Myelofibrosis [NA]
This clinical trial update indicates a study on the clonal architecture of ASXL1-mutated myelofibrosis is currently recruiting at University…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia [Phase 1, Phase 2]
Ongoing Phase 1/2 study of DISC-0974 (RALLY-MF) in patients with myelofibrosis and anemia; the trial is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Interest of CALR Allele Burden in Diagnosis and Follow-up of Patients With CALR Mutated Myeloproliferative Syndromes (CALRSUIVI) [NA]
This clinical trial update notes a study investigating how CALR allele burden aids diagnosis and monitoring in CALR-mutated myeloproliferati…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Karyopharm Expanded Access Program for Selinexor
This update covers Karyopharm's Expanded Access Program for selinexor (Xpovio), including eligibility and current availability for listed ca…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Efficacy and Safety of Gecacitinib Hydrochloride in Prophylaxis Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Myelofibrosis [NA]
A clinical trial evaluating gecacitinib hydrochloride for prophylaxis of acute graft-versus-host disease after allogeneic hematopoietic stem…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Open Label Phase 1/2 Study of Tasquinimod in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), or Post-Essential Thrombocytosis Myelofibrosis (Post-ET MF) [Phase 1, Phase 2]
An open-label Phase 1/2 study evaluating tasquinimod in primary myelofibrosis and myelofibrosis following PV or essential thrombocythemia is…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis [Phase 3]
Phase 3 clinical trial update for pacritinib in primary myelofibrosis and myelofibrosis following polycythemia vera or essential thrombocyth…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Bomedemstat (IMG-7289) in Combination With Momelotinib in Patients With Myelofibrosis [Phase 2]
A Phase 2 clinical trial is investigating bomedemstat in combination with momelotinib for myelofibrosis, with the study status listed as not…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Ruxolitinib Before, During and After Hematopoietic Cell Transplant in Older Patients With Myelofibrosis and Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes [Phase 2]
Phase 2 clinical trial evaluating ruxolitinib before, during, and after hematopoietic cell transplant in older patients with myelofibrosis a…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: A New Diagnostic Algorithm to Non-invasively Track Fibrotic Changes in Myeloproliferative Neoplasms Based on C-C Chemokine Receptor 2 Detection. From Flow Cytometry to the Development of Targeted Positron Emission Tomography Molecular Imaging. Pre-clinical Studies and First In-human Proof of Concept [NA]
Early-stage research describing a non-invasive diagnostic approach using CCR2-targeted PET imaging to monitor fibrotic changes in myelofibro…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia [Phase 2]
Phase 2 trial evaluating selinexor as monotherapy in patients with JAK inhibitor-naïve myelofibrosis and thrombocytopenia is currently recru…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis [Phase 2]
Phase 2 clinical trial evaluating reduced-dose post-transplant cyclophosphamide as GVHD prophylaxis in HLA-mismatched unrelated donor periph…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: A Study of Elritercept Alone or Together With Ruxolitinib in Adults With Myelofibrosis [Phase 2]
Phase 2 clinical trial evaluating elritercept alone or with ruxolitinib in adults with myelofibrosis; recruitment is ongoing.
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow [Phase 1, Phase 2]
A Phase 1/2 clinical trial investigates repurposing the HIV drug Nelfinavir to improve iron delivery to the bone marrow in patients with mye…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms [Phase 1]
Phase 1 clinical trial evaluating a triple combination of navitoclax, venetoclax, and decitabine for advanced myeloid neoplasms. The study i…
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: A Study of Rebecsinib for Patients With Relapsed/Refractory Secondary Acute Myeloid Leukemia or High Risk Myelofibrosis [Phase 1]
This is a Phase 1 clinical trial evaluating rebecsinib in patients with relapsed/refractory secondary acute myeloid leukemia or high-risk my…