Monoclonal Gammopathy of Undetermined Significance
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CLINICAL_TRIALS trial_result · 2025-09-25Clinical Trial Update: PROFAST Intervention in Precursor Multiple Myeloma [NA]
A Dana-Farber Cancer Institute trial evaluating the PROFAST intervention in precursor states to multiple myeloma has completed (NCT05565638)…
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CLINICAL_TRIALS trial_result · 2025-08-19Clinical Trial Update: The Development and Pilot Testing of a New MR Imaging Protocol to Quantify Myeloma Disease Burden and Bone Loss
This clinical trial update reports the development and pilot testing of a new magnetic resonance imaging protocol to quantify multiple myelo…
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Early Detection of Multiple Myeloma to Fight Cancer Disparities: A Screening and Patient Navigation Program [NA]
This is a clinical trial update for a screening and patient navigation program aimed at early detection of multiple myeloma and related diso…
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CLINICAL_TRIALS research · 2025-07-15Clinical Trial Update: A Prospective Long-term Observational Study in Patients With Monoclonal Gammopathy of Undetermined Significance
An ongoing prospective long-term observational study in patients with monoclonal gammopathy of undetermined significance (MGUS), sponsored b…
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Determine the Frequency of Variants in the GBA/PSAP Genes in Patients With MM or MGUS
A protocol to determine the frequency of variants in the GBA and PSAP genes among patients with monoclonal gammopathy of undetermined signif…
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CLINICAL_TRIALS research · 2025-04-08Clinical Trial Update: Zanubrutinib Treatment in Patients With IgM Monoclonal Gammopathy and Antri-MAG Related Polyneuropathy [Phase 2]
A Phase 2 clinical trial investigating zanubrutinib for IgM monoclonal gammopathy with anti-MAG-related polyneuropathy is currently recruiti…
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CLINICAL_TRIALS research · 2025-04-06Clinical Trial Update: Screening and Therapeutic Monitoring of Multiple Myeloma by MALDI-TOF MS Analysis
This clinical trial update describes evaluating MALDI-TOF mass spectrometry for screening and monitoring treatment response in multiple myel…
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Whole Body MRI in Oncology
This clinical trial update describes a study evaluating whole-body MRI in oncology across multiple cancer types, currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-02-18Clinical Trial Update: A Study of a Plant-Based Diet in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) [NA]
A Memorial Sloan Kettering Cancer Center trial is evaluating a plant-based diet in people with Monoclonal Gammopathy of Undetermined Signifi…
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CLINICAL_TRIALS other · 2024-12-27Clinical Trial Update: Characteristics and Clinical Significance of Gut Microbiota in Patients With Monoclonal Gammopathy
This clinical trial examines the characteristics and potential clinical significance of gut microbiota in patients with monoclonal gammopath…
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CLINICAL_TRIALS trial_result · 2024-12-18Clinical Trial Update: Observation of the Incidence and Natural History of MGUS in Patients Undergoing Weight Reduction Surgery
This completed clinical trial evaluated the incidence and natural history of monoclonal gammopathy of undetermined significance (MGUS) in pa…
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CLINICAL_TRIALS trial_result · 2024-10-28Clinical Trial Update: Screening to Improve Survival in AL Amyloidosis
The clinical trial update reports completion of a screening-based study aimed at improving survival in light-chain (AL) amyloidosis. The stu…
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CLINICAL_TRIALS withdrawal · 2024-10-03Clinical Trial Update: B-Cell Hematologic Malignancy Vaccination Registry
A clinical trial update indicates that the B-cell hematologic malignancy vaccination registry (NCT02298816) sponsored by Wake Forest Univers…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: Intestinal Flora and Immunity in Monoclonal Gammopathy Patients
An ongoing clinical trial from Zhujiang Hospital is evaluating whether gut microbiota modulates immune responses in patients with monoclonal…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Dysregulation of Glutamine Activity in the Pathogenesis of Multiple Myeloma [NA]
A completed clinical trial update examining whether dysregulated glutamine metabolism contributes to the pathogenesis of multiple myeloma. T…
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CLINICAL_TRIALS research · 2024-07-12Clinical Trial Update: Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer [Phase 2]
Phase 2 clinical trial evaluating curcumin and piperine in patients under surveillance for monoclonal gammopathy, smoldering multiple myelom…
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CLINICAL_TRIALS research · 2024-07-09Clinical Trial Update: Screening for Monoclonal Gammopathy in Individuals Undergoing Physical Examinations Using iMS-LC Assay Technology.
A clinical trial update describes a screening study using iMS-LC assay technology to detect monoclonal gammopathy and M-protein during physi…
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CLINICAL_TRIALS trial_result · 2021-11-09Clinical Trial Update: Isatuximab in Type I Cryoglobulinemia [Phase 2]
Phase 2 trial update for isatuximab in cryoglobulinemic vasculitis associated with monoclonal gammopathies isatuximab is being studied; curr…
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CLINICAL_TRIALS trial_result · 2019-01-30Clinical Trial Update: Study of High-dose Influenza Vaccine Efficacy by Repeated Dosing IN Gammopathy Patients [Phase 2]
A Phase 2 trial evaluating repeated dosing of a high-dose influenza vaccine in patients with gammopathy (including multiple myeloma and rela…
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CLINICAL_TRIALS trial_result · 2018-09-11Clinical Trial Update: Study of Lenalidomide as a Treatment for Neuropathy Associated With Monoclonal Gammopathy of Undetermined Significance [Phase 2]
Phase 2 trial investigating lenalidomide for neuropathy associated with nonmalignant MGUS; study terminated with results posted in 2018.
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CLINICAL_TRIALS trial_result · 2017-03-16Clinical Trial Update: Genomic and Psychosocial Effects of the 3RP on Patients With MGUS and Smoldering Multiple Myeloma [NA]
ClinicalTrials.gov entry noting the completed study evaluating genomic and psychosocial effects of the 3RP in patients with Monoclonal Gammo…
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CLINICAL_TRIALS research · 2016-10-07Clinical Trial Update: S0120, Studying Blood and Bone Marrow Samples From Patients With Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, or Plasmacytoma
This clinical trial update describes the S0120 study that collects blood and bone marrow samples from patients with monoclonal gammopathy of…
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CLINICAL_TRIALS trial_result · 2015-06-09Clinical Trial Update: Celecoxib in Preventing Multiple Myeloma in Patients With Monoclonal Gammopathy or Smoldering Myeloma [Phase 2]
A Phase 2 trial update on using celecoxib to prevent progression to multiple myeloma in patients with MGUS or smoldering myeloma; the study …
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CLINICAL_TRIALS trial_result · 2015-04-03Clinical Trial Update: S0309, Repository: Blood/Bone Marrow From Pts. With Myeloma, WM, Amyloidosis, or MGUS.
A SWOG trial (NCT00919139) evaluating a blood/bone marrow repository from patients with multiple myeloma, smoldering myeloma, Waldenström's …
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CLINICAL_TRIALS trial_result · 2015-03-27Clinical Trial Update: Green Tea Extract in Treating Patients With Monoclonal Gammopathy of Undetermined Significance and/or Smoldering Multiple Myeloma [Phase 2]
Phase 2 trial evaluating green tea extract in patients with MGUS and/or smoldering multiple myeloma; the study was terminated with results p…