Castration-resistant Prostate Cancer
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: 177^Lu-PSMA-617 in Combination With Sipuleucel-T for the Treatment of Metastatic Castration-Resistant Prostate Cancer [Phase 1]
This Phase 1 trial is evaluating the combination of 177Lu-PSMA-617 with sipuleucel-T for metastatic castration-resistant prostate cancer, an…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors [Phase 1, Phase 2]
IDEAYA Biosciences is conducting a Phase 1/2 study to evaluate the safety, pharmacokinetics, and preliminary efficacy of IDE574 in adults wi…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: A Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer [Phase 2]
A Phase 2 clinical trial evaluated lorigerlimab in combination with docetaxel versus docetaxel alone in metastatic castration-resistant pros…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Pembrolizumab Plus 177Lu-PSMA-617 in Patients With Castration Resistant Prostate Cancer [Phase 2]
Phase 2 clinical trial evaluating pembrolizumab in combination with 177Lu-PSMA-617 for castration-resistant prostate cancer, including metas…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: A Study of JNJ-75229414 for Metastatic Castration-resistant Prostate Cancer Participants [Phase 1]
This document reports a completed Phase 1 clinical trial of JNJ-75229414 for metastatic castration-resistant prostate cancer.
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy [Phase 1, Phase 2]
An early-phase clinical trial is evaluating Radium-223 dichloride alone or in combination with M3814 and/or Avelumab for metastatic castrati…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A) [Phase 1, Phase 2]
This document announces a Phase 1/2 clinical trial evaluating Opevesostat (MK-5684) alone or in combination for metastatic castration-resist…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: A Study to Learn How Safe the Study Treatment Actinium-225-macropa-pelgifatamab (BAY3546828) is, How it Affects the Body, How it Moves Into, Through and Out of the Body, and About Its Anticancer Activity in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC) [Phase 1]
Phase 1 clinical trial evaluating safety, pharmacokinetics, and anticancer activity of BAY3546828 (Actinium-225-macropa-pelgifatamab) in pat…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: 3D1015 Injection for Patients With mCRPC [Phase 1]
A Phase 1 clinical trial evaluating 3D1015 Injection in patients with metastatic castration-resistant prostate cancer is currently recruitin…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma [Phase 1]
Pfizer is conducting a Phase 1 study of mevrometostat for relapsed/refractory small cell lung cancer, metastatic castration-resistant prosta…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01) [Phase 1, Phase 2]
This document outlines a two-part clinical trial (Phase 1 dose escalation/expansion followed by Phase 2) of Tulmimetostat and Luxdegalutamid…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer. [Phase 3]
A Phase 3 clinical trial is evaluating how PF-06821497 (Mevrometostat) works in men with metastatic castration-resistant prostate cancer; th…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Phase I Clinical Study of HLX3902 in Patients With mCRPC and Other Advanced Tumours [Phase 1]
Phase I clinical study of HLX3902 in metastatic castration-resistant prostate cancer and other advanced/metastatic solid tumors; the trial s…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Platinum and Taxane Chemo in Met Castration Resistant Prostate Cancer Patients With Alterations in DNA Damage Response Genes [Phase 3]
A Phase 3 clinical trial in recruiting evaluating platinum- and taxane-based chemotherapy for metastatic castration-resistant prostate cance…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Study of PF-07248144 in Advanced or Metastatic Solid Tumors [Phase 2]
Pfizer is conducting a Phase 2 study of PF-07248144 in locally advanced or metastatic ER+ HER2- breast cancer, locally advanced or metastati…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: 177Lu-PSMA-617 in Metastatic Castration Resistant Prostate Cancer (mCRPC) With Bone Marrow Involvement and Cytopenia [Phase 2]
Phase 2 trial of 177Lu-PSMA-617 for metastatic castration-resistant prostate cancer with bone marrow involvement and cytopenia has been susp…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Investigating SX-682 in Combination With Apalutamide in Metastatic Castration-resistant Prostate Cancer [Phase 1, Phase 2]
This clinical trials entry reports a Phase 1/2 study evaluating SX-682 in combination with apalutamide for metastatic castration-resistant p…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial [NA]
This clinical trial is investigating cryoablation combined with stereotactic body radiation therapy for painful bone metastases in patients …
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: RADIANT: A Study of Radium-223 Dichloride (Xofigo) vs Enzalutamide or Abiraterone (ARPIs, Androgen Receptor Pathway Inhibitors) in Patients With Prostate Cancer That Has Spread to the Bones (mCRPC, Metastatic Castration-Resistant Prostate Cancer) [Phase 4]
This Phase 4 trial (RADIANT) compares Radium-223 Dichloride (Xofigo) versus Enzalutamide or Abiraterone in metastatic castration-resistant p…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Green Tea and Quercetin in Combination With Docetaxel Chemotherapy in Castration-resistant Prostate Cancer Patients [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial is investigating the combination of docetaxel chemotherapy with green tea extract and quercetin in metastat…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Golimumab and Apalutamide for the Treatment of Castration-Resistant Prostate Cancer, TRAMP Study [Phase 2]
Phase 2 trial (TRAMP) testing the combo of golimumab and apalutamide for metastatic castration-resistant prostate cancer is active but not c…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer [Phase 3]
A Phase 3 clinical trial is evaluating Pasritamig with docetaxel versus docetaxel alone in metastatic castration-resistant prostate cancer a…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Testing the Effect of M1774 on Hard-to-Treat Refractory SPOP-mutant Prostate Cancer [Phase 2]
Phase 2 trial evaluating M1774 in hard-to-treat prostate cancer is currently active but not recruiting. The study targets castration-resista…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: A Study to Evaluate the Effect of Multiple Doses of JNJ-56021927 on the Pharmacokinetics of Multiple Cytochrome P450 and Transporter Substrates in Participants With Castration-Resistant Prostate Cancer [Phase 1]
A Phase 1 clinical trial update evaluating the effect of multiple doses of JNJ-56021927 on the pharmacokinetics of various cytochrome P450 s…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer [Phase 1]
Phase 1 clinical trial evaluating ARN-509 (apalutamide) in combination with abiraterone acetate in participants with metastatic castration-r…