Castration-resistant Prostate Cancer

• CLINICAL_TRIALS trial_result · 2025-12-05
  Clinical Trial Update: pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate Cancer [Phase 2]

  Phase 2 trial evaluating pTVG-HP DNA vaccine with or without the pTVG-AR DNA vaccine plus pembrolizumab in castration-resistant, metastatic …

• CLINICAL_TRIALS research · 2025-12-04
  Clinical Trial Update: Adaptive Abiraterone Therapy for Metastatic Castration Resistant Prostate Cancer [EARLY_Phase 1]

  The document reports an early-phase trial of adaptive Abiraterone therapy for metastatic castration-resistant prostate cancer and notes the …

• CLINICAL_TRIALS research · 2025-12-04
  Clinical Trial Update: Safety and Efficacy Evaluation of Anti IGF-1R Monoclonal Antibody Combined With Anti-PD-1 Monoclonal Antibody in Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer [EARLY_Phase 1]

  An early-phase study evaluating the safety and preliminary efficacy of combining an anti-IGF-1R monoclonal antibody with an anti-PD-1 monocl…

• CLINICAL_TRIALS research · 2025-12-02
  Clinical Trial Update: ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC [Phase 1, Phase 2]

  Clinical trial update for ONC-392 in combination with Lutetium-177 vipivotide tetraxetan in metastatic castration-resistant prostate cancer …

• CLINICAL_TRIALS research · 2025-11-28
  Clinical Trial Update: Bortezomib in Patients With Metastatic Castration-Resistant Prostate Cancer With PTEN Deletion [Phase 2]

  A Phase 2 clinical trial is evaluating bortezomib in patients with metastatic castration-resistant prostate cancer with PTEN deletion; recru…

• Want full summaries, importance scores, and drug timelines? Upgrade to Plus or Pro.
• CLINICAL_TRIALS research · 2025-11-26
  Clinical Trial Update: A Clinical Study on the Efficacy and Safety of Fasudil Hydrochloride Combined With Immunotherapy in the Treatment of Metastatic Castration-resistant Prostate Cancer [Phase 2]

  A Phase 2 clinical trial is evaluating the efficacy and safety of fasudil hydrochloride in combination with immunotherapy for metastatic cas…

• CLINICAL_TRIALS research · 2025-11-24
  Clinical Trial Update: Combination Study of Antibiotics With Enzalutamide (PROMIZE) [Phase 1, Phase 2]

  Clinical trial update for the PROMIZE study evaluating a combination of antibiotics with enzalutamide in metastatic castration-resistant pro…

• CLINICAL_TRIALS research · 2025-11-24
  Clinical Trial Update: Lutetium (177Lu) DGUL Combined With Pembrolizumab in Metastatic Castration-Resistant Prostate Cancer [Phase 1]

  Phase 1 study assessing Lutetium-177-DGUL in combination with Pembrolizumab for metastatic castration-resistant prostate cancer; the trial s…

• CLINICAL_TRIALS research · 2025-11-21
  Clinical Trial Update: A Clinical Study Evaluating the Safety and Efficacy of Local Injection of ACT#001 Chimeric Antigen Receptor T Cells in the Treatment of Castration-Resistant Prostate Cancer [EARLY_Phase 1]

  This early-phase clinical trial updates on the safety and efficacy of locally injected ACT#001 CAR-T cells for castration-resistant prostate…

• CLINICAL_TRIALS research · 2025-11-21
  Clinical Trial Update: Study of TVB-2640 in Men With Metastatic Castration-Resistant Prostate Cancer [Phase 1]

  An update indicates that a Phase 1 study of TVB-2640 in men with metastatic castration-resistant prostate cancer is currently recruiting.

• CLINICAL_TRIALS research · 2025-11-19
  Clinical Trial Update: PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer [Phase 1]

  A Phase 1 trial is evaluating PSCA-targeting CAR-T cells with or without radiation in patients with PSCA-expressing metastatic castration-re…

• CLINICAL_TRIALS research · 2025-11-19
  Clinical Trial Update: Memantine Hydrochloride in Prostate Cancer Patients [Phase 2]

  A Phase 2 clinical trial evaluating memantine hydrochloride in metastatic castration-resistant prostate cancer and other prostate cancers, c…

• CLINICAL_TRIALS trial_result · 2025-11-17
  Clinical Trial Update: A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors [Phase 2]

  Phase 2 study evaluating SOT101 in combination with pembrolizumab in selected advanced solid tumors was terminated; results have been posted…

• CLINICAL_TRIALS trial_result · 2025-11-12
  Clinical Trial Update: Decitabine/Cedazuridine and Enzalutamide for the Treatment of Metastatic Castrate Resistant Prostate Cancer [Phase 1]

  Phase 1 clinical trial evaluating a combination of decitabine/cedazuridine with enzalutamide in metastatic castration-resistant prostate can…

• CLINICAL_TRIALS research · 2025-11-10
  Clinical Trial Update: Pacritinib in Participants With Metastatic Castrate-Resistant Prostate Cancer That Progressed on or After Prior Treatment With Androgen Receptor Signaling Inhibitors [Phase 2]

  Phase 2 clinical trial evaluating pacritinib in metastatic castration-resistant prostate cancer that progressed after prior androgen recepto…

• CLINICAL_TRIALS trial_result · 2025-11-06
  Clinical Trial Update: Testosterone Therapy in Castration Resistant Prostate Cancer [EARLY_Phase 1]

  A Phase 1 trial evaluating testosterone therapy in men with castration-resistant prostate cancer has completed.

• CLINICAL_TRIALS trial_result · 2025-11-06
  Clinical Trial Update: A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors [Phase 1, Phase 2]

  A clinical trial update on REGN5678 (Nezastomig) alone or in combination with cemiplimab to treat metastatic castration-resistant prostate c…

• CLINICAL_TRIALS research · 2025-11-04
  Clinical Trial Update: Sipuleucel-T Combined With Bipolar Androgen Therapy in Men With mCRPC [Phase 2]

  This clinical trial update describes a Phase 2 study evaluating sipuleucel-T in combination with Bipolar Androgen Therapy for metastatic cas…

• CLINICAL_TRIALS research · 2025-11-04
  Clinical Trial Update: Androgen Receptor Directed Therapy on Cognitive Function in Patients Treated With Darolutamide or Enzalutamide [Phase 2]

  Phase 2 clinical trial evaluating the effect of androgen receptor–directed therapies (darolutamide or enzalutamide) on cognitive function in…

• CLINICAL_TRIALS research · 2025-10-31
  Clinical Trial Update: Dose-Escalation Study of Cabozantinib in Combination With Lutetium-177 (177Lu)-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer [Phase 1]

  This is a Phase 1 dose-escalation trial evaluating cabozantinib in combination with Lutetium-177 PSMA-617 for metastatic castration-resistan…

• CLINICAL_TRIALS trial_result · 2025-10-29
  Clinical Trial Update: ProSTAR: A Study Evaluating CPI-1205 in Patients With Metastatic Castration Resistant Prostate Cancer [Phase 1, Phase 2]

  Results from a Phase 1/2 study of CPI-1205 in metastatic castration-resistant prostate cancer have been posted; the trial is completed.

• CLINICAL_TRIALS other · 2025-10-24
  Clinical Trial Update: Evaluation of the Change in PSMA Expression in Prostate Cancer in Response to Hormonal Therapy [Phase 4]

  A Phase 4 clinical trial is evaluating changes in PSMA expression in prostate cancer in response to hormonal therapy, including both castrat…

• CLINICAL_TRIALS research · 2025-10-21
  Clinical Trial Update: Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects [Phase 2]

  This is a Phase 2 clinical trial update evaluating Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone plus Olaparib in patients wit…

• CLINICAL_TRIALS trial_result · 2025-10-20
  Clinical Trial Update: A Trial of BXCL701 and Pembrolizumab in Patients With mCRPC Either Small Cell Neuroendocrine Prostate Cancer or Adenocarcinoma Phenotype. [Phase 1, Phase 2]

  A Phase 1/2 trial evaluating BXCL701 in combination with pembrolizumab for metastatic castration-resistant prostate cancer with small cell n…

• CLINICAL_TRIALS trial_result · 2025-10-16
  Clinical Trial Update: Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC [Phase 1]

  Phase 1 study evaluating Acapatamab in metastatic castration-resistant prostate cancer reports safety, tolerability, pharmacokinetics, and p…