Castration-resistant Prostate Cancer

• CLINICAL_TRIALS trial_result · 2025-12-05
  Clinical Trial Update: pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate Cancer [Phase 2]

  Phase 2 trial evaluating pTVG-HP DNA vaccine with or without the pTVG-AR DNA vaccine plus pembrolizumab in castration-resistant, metastatic …

• CLINICAL_TRIALS trial_result · 2025-11-17
  Clinical Trial Update: A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors [Phase 2]

  Phase 2 study evaluating SOT101 in combination with pembrolizumab in selected advanced solid tumors was terminated; results have been posted…

• CLINICAL_TRIALS trial_result · 2025-11-12
  Clinical Trial Update: Decitabine/Cedazuridine and Enzalutamide for the Treatment of Metastatic Castrate Resistant Prostate Cancer [Phase 1]

  Phase 1 clinical trial evaluating a combination of decitabine/cedazuridine with enzalutamide in metastatic castration-resistant prostate can…

• CLINICAL_TRIALS trial_result · 2025-11-06
  Clinical Trial Update: Testosterone Therapy in Castration Resistant Prostate Cancer [EARLY_Phase 1]

  A Phase 1 trial evaluating testosterone therapy in men with castration-resistant prostate cancer has completed.

• CLINICAL_TRIALS trial_result · 2025-11-06
  Clinical Trial Update: A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors [Phase 1, Phase 2]

  A clinical trial update on REGN5678 (Nezastomig) alone or in combination with cemiplimab to treat metastatic castration-resistant prostate c…

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• CLINICAL_TRIALS trial_result · 2025-10-29
  Clinical Trial Update: ProSTAR: A Study Evaluating CPI-1205 in Patients With Metastatic Castration Resistant Prostate Cancer [Phase 1, Phase 2]

  Results from a Phase 1/2 study of CPI-1205 in metastatic castration-resistant prostate cancer have been posted; the trial is completed.

• CLINICAL_TRIALS trial_result · 2025-10-20
  Clinical Trial Update: A Trial of BXCL701 and Pembrolizumab in Patients With mCRPC Either Small Cell Neuroendocrine Prostate Cancer or Adenocarcinoma Phenotype. [Phase 1, Phase 2]

  A Phase 1/2 trial evaluating BXCL701 in combination with pembrolizumab for metastatic castration-resistant prostate cancer with small cell n…

• CLINICAL_TRIALS trial_result · 2025-10-16
  Clinical Trial Update: Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC [Phase 1]

  Phase 1 study evaluating Acapatamab in metastatic castration-resistant prostate cancer reports safety, tolerability, pharmacokinetics, and p…

• CLINICAL_TRIALS trial_result · 2025-10-14
  Clinical Trial Update: I-131-1095 Radioligand Plus Enzalutamide vs Enzalutamide for mCRPC That Progressed During Abiraterone (ARROW). [Phase 2]

  Phase 2 ARROW trial comparing I-131-1095 radioligand plus enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate…

• CLINICAL_TRIALS trial_result · 2025-10-14
  Clinical Trial Update: Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies [Phase 1, Phase 2]

  This Phase 1/2 trial assesses a combination of Avelumab, Utomilumab, and anti-OX40 PF-04518600 with radiation therapy in patients with advan…

• CLINICAL_TRIALS trial_result · 2025-10-14
  Clinical Trial Update: A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors [Phase 1]

  This Phase 1 trial update reports on the combination of MGC018 and MGD019 in participants with advanced solid tumors, including castration-r…

• CLINICAL_TRIALS trial_result · 2025-10-09
  Clinical Trial Update: 177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer [Phase 3]

  Phase 3 trial comparing Lutetium-177 PSMA-617 with androgen receptor–directed therapy in progressive metastatic castration-resistant prostat…

• CLINICAL_TRIALS trial_result · 2025-10-09
  Clinical Trial Update: 177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer [Phase 3]

  A Phase 3 trial comparing 177Lu-PSMA-617 with androgen receptor-directed therapy for progressive metastatic castration-resistant prostate ca…

• CLINICAL_TRIALS trial_result · 2025-10-07
  Clinical Trial Update: Fractionated Docetaxel and Radium 223 in Metastatic Castration-Resistant Prostate Cancer [Phase 1]

  This update reports the completion of a Phase 1 trial evaluating fractionated docetaxel in combination with radium-223 in metastatic castrat…

• CLINICAL_TRIALS trial_result · 2025-10-07
  Clinical Trial Update: Safety and Efficacy of Therapies for Metastatic Castration-resistant Prostate Cancer (mCRPC) [Phase 1, Phase 2]

  A Phase 1/2 clinical trial for metastatic castration-resistant prostate cancer conducted by Amgen has been terminated.

• CLINICAL_TRIALS trial_result · 2025-10-06
  Clinical Trial Update: Trial Evaluating the Efficacy of CARBOPLATIN in Metastatic Prostate Cancer With Gene Alterations in the Homologous Recombination Pathway [Phase 2]

  This document reports on a completed Phase 2 trial evaluating the efficacy of carboplatin in metastatic prostate cancer with homologous reco…

• CLINICAL_TRIALS trial_result · 2025-10-03
  Clinical Trial Update: 177Lu-P17-087/177Lu-P17-088 in Patients With Metastatic Castration-resistant Prostate Cancer [EARLY_Phase 1]

  The study investigates two radiopharmaceuticals, 177Lu-P17-087 and 177Lu-P17-088, in patients with metastatic castration-resistant prostate …

• CLINICAL_TRIALS trial_result · 2025-10-02
  Clinical Trial Update: Abemaciclib With or Without Atezolizumab for mCRPC [Phase 2]

  This Phase 2 trial evaluates abemaciclib with or without atezolizumab in metastatic castration-resistant prostate cancer, with results poste…

• CLINICAL_TRIALS trial_result · 2025-09-22
  Clinical Trial Update: 18F-fluciclovine PET in Metastatic Castration Resistant Prostate Cancer Treated With Life Prolonging Therapies [Phase 2]

  Phase 2 study evaluating 18F-fluciclovine PET imaging in metastatic castration-resistant prostate cancer patients treated with life-prolongi…

• CLINICAL_TRIALS trial_result · 2025-09-22
  Clinical Trial Update: Safety and Efficacy of Oral Testosterone Undecanoate Followed by Enzalutamide as Therapy for Men With Metastatic Castrate Resistant Prostate Cancer [Phase 2]

  This Phase 2 trial evaluating sequential oral testosterone undecanoate followed by enzalutamide in men with metastatic castration-resistant …

• CLINICAL_TRIALS trial_result · 2025-09-18
  Clinical Trial Update: Study Evaluating Zenocutuzumab in Patients With or Without Molecularly Defined Cancers [Phase 2]

  A Phase 2 trial evaluating Zenocutuzumab in patients with molecularly defined cancers, including non-small cell lung cancer with NRG1 fusion…

• CLINICAL_TRIALS trial_result · 2025-09-15
  Clinical Trial Update: Clinical Trial to Evaluate the Tolerance of TQB3201 Tablets [Phase 1, Phase 2]

  This clinical trial update reports that TQB3201 tablets are being evaluated for tolerability in metastatic castration-resistant prostate can…

• CLINICAL_TRIALS trial_result · 2025-09-12
  Clinical Trial Update: Apalutamide and Abiraterone Acetate in African American and Caucasian Men With Metastatic Castrate Resistant Prostate Cancer [Phase 2]

  This Phase 2 trial evaluating apalutamide and abiraterone acetate in African American and Caucasian men with metastatic castration-resistant…

• CLINICAL_TRIALS trial_result · 2025-09-11
  Clinical Trial Update: Schedule De-Escalation of 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer [Phase 2]

  This clinical trial update describes a Phase 2 study evaluating schedule de-escalation of 177Lu-PSMA-617 for metastatic castration-resistant…

• CLINICAL_TRIALS trial_result · 2025-09-09
  Clinical Trial Update: A Trial of Triamcinolone With a GnRH Analog for Castration Resistant Prostate Cancer [Phase 2]

  This Phase 2 trial update reports completion of a study evaluating the combination of Triamcinolone with a GnRH analog in patients with cast…