Castration-resistant Prostate Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: A Study of SYNC-T Therapy SV-102 in Participants With Metastatic Castration-Resistant Prostate Cancer [Phase 2]
A Phase 2 clinical trial of SYNC-T Therapy SV-102 for metastatic castration-resistant prostate cancer is currently recruiting. The sponsor i…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With Cemiplimab or REGN5678 for Adult Participants With Advanced Prostate Cancer [Phase 1, Phase 2]
Regeneron is conducting a Phase 1/2 clinical trial to evaluate REGN4336 alone and in combination with cemiplimab or REGN5678 for adults with…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation [Phase 2]
A Phase 2 clinical trial of checkpoint inhibitors in men with progressive metastatic castration-resistant prostate cancer characterized by m…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC [Phase 3]
Novartis is running a Phase 3 trial comparing AAA817 combined with an androgen receptor pathway inhibitor (ARPI) versus standard of care in …
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: A Study of DS9051b in Participants With Advanced or Metastatic Adrenocortical Carcinoma and Metastatic Castration-resistant Prostate Cancer [Phase 1]
A Phase 1 trial update for DS9051b in advanced or metastatic adrenocortical carcinoma and metastatic castration-resistant prostate cancer, c…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: CART-PSMA-TGFβRDN Cells for Castrate-Resistant Prostate Cancer [Phase 1]
Phase 1 clinical trial update for CART-PSMA-TGFβRDN cells targeting prostate cancer; the study is active but not recruiting.
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors [Phase 1, Phase 2]
This is a Phase 1/2 clinical trial evaluating GVV858 as a single agent or in combination with endocrine therapy for hormone receptor-positiv…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: COMPASS Study for Metastatic Castration-resistant Prostate Cancer
The COMPASS trial at Duke University is currently recruiting for metastatic castration-resistant prostate cancer.
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: A Study of ITC-6146RO in Patients With Advanced or Metastatic Cancer Who Have Failed Standard Therapy [Phase 1]
Phase 1 study of ITC-6146RO in patients with advanced or metastatic cancers after standard therapy; the trial is not yet recruiting.
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Observational Study on Lutetium (177Lu) Vipivotide Tetraxetan to Treat Metastatic Castration Resistant Prostate Cancer
An observational study evaluating lutetium-177 vipivotide tetraxetan for metastatic castration-resistant prostate cancer is currently recrui…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Phase Ib/IIa Dose Escalation and Expansion Study of [²¹²Pb]Pb-ADVC001 in Metastatic Prostate Cancer (TheraPb - Phase I/II Study). [Phase 1, Phase 2]
This entry describes a Phase Ib/IIa dose-escalation and expansion trial of the radiopharmaceutical [212Pb]Pb-ADVC001 for metastatic prostate…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced Prostate Cancer With Bone Metastasis [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the safety of different doses of olaparib given with radium-223 in men with advanced prostate cancer w…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer
Trial exploring whether DNA repair pathway alterations affect Radium-223 efficacy in bone-metastatic castration-resistant prostate cancer; c…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Fractionated and Multiple Dose 225Ac-J591 for Progressive mCRPC [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/Phase 2 study of 225Ac-J591 for progressive metastatic castration-resistant prostate cancer, …
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Cell Therapy (STEAP1 CART) With Enzalutamide for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial is investigating STEAP1-targeted CAR-T cell therapy in combination with enzalutamide for metastatic castration-re…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365) [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study of pembrolizumab (MK-3475) combination therapies for metastatic castration-resistant …
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Dosimetry of [177Lu]Lu-PSMA-617 in Chinese Adult Male Patients With Progressive PSMA-Positive mCRPC [Phase 2]
ClinicalTrials.gov update for a Phase 2 study evaluating efficacy, safety, pharmacokinetics, and dosimetry of Lu-177 PSMA-617 in Chinese adu…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Enfortumab Vedotin as Monotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer [Phase 2]
Phase 2 study evaluating enfortumab vedotin as monotherapy in metastatic castration-resistant prostate cancer; trial is currently active and…
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Bipolar Androgen Therapy (BAT) and Radium-223 (RAD) in Metastatic Castration-resistant Prostate Cancer (mCRPC) [Phase 2]
This entry covers a Phase 2 clinical trial evaluating Bipolar Androgen Therapy (BAT) in combination with Radium-223 for metastatic castratio…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: 64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for Identification and Treatment of PSMA-expressing Metastatic Castrate Resistant Prostate Cancer (SECuRE) [Phase 1, Phase 2]
This is a clinical trial update for SECuRE, investigating 64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for identification and treatment of PSMA-exp…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy [Phase 3]
A Phase 3 clinical trial is evaluating whether adding rucaparib to enzalutamide improves outcomes for men with metastatic castration-resista…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: A Phase III Study Comparing HRS-4357 With Novel Androgen Receptor Pathway Inhibitors in Patients With Progressive, PSMA-Positive Metastatic Castration-Resistant Prostate Cancer [Phase 3]
A Phase 3 study evaluating HRS-4357 versus novel androgen receptor pathway inhibitors for PSMA-positive metastatic castration-resistant pros…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC) [Phase 1]
A Phase 1 study evaluating valemetostat (DS-3201b) in combination with darolutamide for metastatic castration-resistant prostate cancer is c…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer [Phase 1]
A Phase 1 clinical trial evaluating BMS-986460 in participants with metastatic castration-resistant prostate cancer is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition Therapy
Clinical trial update describing gene expression analyses in patients with metastatic prostate cancer treated with a CYP-17 inhibitor.