Melanoma
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CLINICAL_TRIALS trial_result · 2018-05-15Clinical Trial Update: Addition of Ipilimumab (MDX-010) To Isolated Limb Infusion (ILI) With Standard Melphalan and Dactinomycin In The Treatment of Advanced Unresectable Melanoma of The Extremity [Phase 2]
Phase 2 clinical trial evaluating the addition of ipilimumab to isolated limb infusion with melphalan and dactinomycin for advanced unresect…
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CLINICAL_TRIALS trial_result · 2018-05-15Clinical Trial Update: A Phase 1B Clinical Trial of Trametinib Plus Digoxin in Patients With Unresectable or Metastatic BRAF Wild-type Melanoma [Phase 1]
This update reports results from a Phase 1B trial evaluating the combination of trametinib and digoxin in patients with unresectable or meta…
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CLINICAL_TRIALS withdrawal · 2018-05-15Clinical Trial Update: A Clinical Trial of Patients With Melanoma [Phase 1]
A Phase 1 clinical trial for melanoma sponsored by University of Texas Southwestern Medical Center has been withdrawn.
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CLINICAL_TRIALS trial_result · 2018-05-11Clinical Trial Update: Phase II FANG™ in Advanced Melanoma [Phase 2]
Phase II study of FANG in advanced melanoma was terminated, with results posted in May 2018.
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CLINICAL_TRIALS trial_result · 2018-05-09Clinical Trial Update: Axitinib in Treating Patients With Melanoma That is Metastatic or Cannot Be Removed by Surgery [Phase 2]
A Phase 2 trial evaluating axitinib for metastatic or unresectable melanoma (including intraocular melanoma) has been terminated. Results ha…
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CLINICAL_TRIALS withdrawal · 2018-05-09Clinical Trial Update: ML29255 Neoadjuvant Vemurafenib and Cobimetinib Melanoma [Phase 2]
A Phase 2 neoadjuvant trial of vemurafenib and cobimetinib for Stage IIIB-C melanoma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2018-05-09Clinical Trial Update: Feasibility Study of Genomic Profiling Methods and Timing in Tumor Samples
A completed feasibility study evaluating genomic profiling methods and timing in tumor samples across several cancers, including colorectal,…
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CLINICAL_TRIALS trial_result · 2018-05-08Clinical Trial Update: Phase I/II Study to Assess the Safety and Activity of Enhanced TCR Transduced Autologous T Cells in Metastatic Melanoma [Phase 1, Phase 2]
A Phase I/II clinical trial assessing safety and activity of enhanced TCR-transduced autologous T cells in metastatic melanoma was terminate…
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CLINICAL_TRIALS trial_result · 2018-05-04Clinical Trial Update: Fosaprepitant for N/V With High-dose Interleukin-2 for Metastatic Melanoma and Renal Cell Carcinoma [Phase 2]
Phase 2 trial of fosaprepitant for preventing chemotherapy-related nausea and vomiting in patients receiving high-dose interleukin-2 for met…
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CLINICAL_TRIALS withdrawal · 2018-05-04Clinical Trial Update: REO13 Melanoma With of Without GM-CSF [Phase 1, Phase 2]
The REO13 trial evaluating melanoma with or without GM-CSF (sargramostim) in Phase 1/2 has been withdrawn.
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CLINICAL_TRIALS trial_result · 2018-05-03Clinical Trial Update: Docetaxel and Vinorelbine Plus Sargramostim in Metastatic Malignant Melanoma [Phase 2]
A Phase 2 trial of docetaxel, vinorelbine, and sargramostim in metastatic melanoma has completed, with results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-05-02Clinical Trial Update: Evaluation of the Immunogenicity of Vaccination With Multiple Synthetic Melanoma Peptides With Granulocyte-macrophage Colony-stimulating Factor (GM-CSF)-In-Adjuvant, in Patients With Advanced Melanoma [Phase 2]
A Phase 2 clinical trial evaluating the immunogenicity of a melanoma peptide vaccine with GM-CSF adjuvant in patients with advanced melanoma…
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CLINICAL_TRIALS trial_result · 2018-04-30Clinical Trial Update: A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer [Phase 1]
A Phase 1 study evaluating varlilumab in combination with atezolizumab in patients with advanced cancers has been terminated.
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CLINICAL_TRIALS trial_result · 2018-04-27Clinical Trial Update: Effectiveness, Safety and Use of Nivolumab Administered During the French Temporary Authorization for Use in Patients With Advanced Melanoma
Clinical trial update reporting on the effectiveness and safety of nivolumab administered under the French Temporary Authorization for Use i…
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FDA approval · 2018-04-20FDA Approved: TAFINLAR — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for TAFINLAR (dabrafenib) submitted by Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS trial_result · 2018-04-20Clinical Trial Update: A Phase II Study of High Dose Bolus IL2 in Patients With Inoperable Stage III or Stage IV Melanoma Who Have Failed Prior Anti-PD1 Immunotherapy: Efficacy and Biomarker Study [Phase 2]
Phase II study of high-dose bolus interleukin-2 in inoperable stage III/IV melanoma after anti-PD1 failure was terminated; results and bioma…
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CLINICAL_TRIALS research · 2018-04-20Clinical Trial Update: Diagnosing Melanoma, Squamous Cell Carcinoma and Basal Cell Carcinoma Using the Spectra-Scope [NA]
This clinical trial update discusses using the Spectra-Scope to diagnose melanoma, squamous cell carcinoma, and basal cell carcinoma of the …
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CLINICAL_TRIALS withdrawal · 2018-04-09Clinical Trial Update: The Effectiveness of Nivolumab Monotherapy as First-Line Therapy in Adults With Advanced Melanoma in Germany
A clinical trial evaluating nivolumab monotherapy as first-line treatment for adults with advanced melanoma in Germany has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2018-04-05Clinical Trial Update: Pembrolizumab and Imatinib in Patients With Locally Advanced/Metastatic Melanoma With c-KIT Mutation/Amplification [Phase 1, Phase 2]
This clinical trial update reports that the Phase 1/2 study of pembrolizumab in combination with imatinib for locally advanced or metastatic…
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CLINICAL_TRIALS trial_result · 2018-04-03Clinical Trial Update: Safety and Efficacy Study of Vemurafenib and High-dose Interferon Alfa-2b in Melanoma [Phase 1]
Phase 1 study evaluating safety and preliminary efficacy of combining vemurafenib with high-dose interferon alfa-2b in melanoma has complete…
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EMA withdrawal · 2018-03-27EMA Application withdrawn: Balimek (binimetinib) — Pierre Fabre Médicament
The EMA withdrew the application for Balimek (binimetinib) by Pierre Fabre Médicament for melanoma.
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CLINICAL_TRIALS trial_result · 2018-03-23Clinical Trial Update: Minimally Invasive Groin Dissection for Melanoma [NA]
The clinical trial evaluating minimally invasive groin dissection for melanoma has completed.
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CLINICAL_TRIALS trial_result · 2018-03-23Clinical Trial Update: Second Echelon Node Study With Methylene Blue [NA]
A Mayo Clinic–sponsored trial evaluating methylene blue for second-echelon sentinel lymph node mapping in breast cancer and melanoma has com…
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CLINICAL_TRIALS trial_result · 2018-03-19Clinical Trial Update: Peptide Vaccine and Temozolomide for Metastatic Melanoma Patients [Phase 2]
A Phase 2 clinical trial combining a peptide vaccine with temozolomide for metastatic melanoma was terminated.
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CLINICAL_TRIALS trial_result · 2018-03-13Clinical Trial Update: A Sunscreen Based on Bioadhesive Nanoparticles [Phase 1]
Phase 1 trial of a sunscreen based on bioadhesive nanoparticles conducted by Yale University has completed, assessing safety and early signa…