Melanoma
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CLINICAL_TRIALS research · 2024-09-25Clinical Trial Update: Study to Examine Lesions of the Skin Using Confocal Laser Microscopy
This document details an active, non-recruiting clinical trial sponsored by LMU Klinikum that uses confocal laser microscopy to examine skin…
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CLINICAL_TRIALS research · 2024-09-23Clinical Trial Update: Gene Expression Profiles and ctDNA for Risk Stratification in Patients With Melanoma
This clinical trial investigates gene expression profiles and circulating tumor DNA (ctDNA) to stratify risk in melanoma patients. The study…
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CLINICAL_TRIALS withdrawal · 2024-09-20Clinical Trial Update: Immunogenicity and Safety of Pneumococcal Vaccination in Patients Treated With Immune Checkpoint Inhibitors
The clinical trial evaluating immunogenicity and safety of pneumococcal vaccination in patients treated with immune checkpoint inhibitors fo…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Hydrochlorothiazide and Risk of Skin Cancer
A completed CNODES study evaluating whether hydrochlorothiazide is associated with an increased risk of skin cancers, including non-melanoma…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Randomized, Controlled, Multi-center, Phase III Clinical Study to Investigate Recombinant Humanized PD-1 Monoclonal Antibody Injection (JS001) Versus Dacarbazine as the 1st-line Therapy for Unresectable or Metastatic Melanoma [Phase 3]
A Phase III randomized trial comparing the PD-1 inhibitor JS001 (toripalimab) to dacarbazine as first-line therapy for unresectable or metas…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Bioequivalence Binimetinib 3 x 15 mg and 45 mg Formulations [Phase 1]
Phase 1 bioequivalence study comparing Binimetinib 3 x 15 mg formulation with a 45 mg formulation in melanoma patients with BRAF V600 mutati…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: PVSRIPO for Patients With Unresectable Melanoma [Phase 1]
Phase 1 trial of PVSRIPO for unresectable melanoma has been terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Treatment of Metastatic Melanoma with Lenvatinib + Anti-PD1
A completed clinical trial evaluating the combination of lenvatinib with an anti-PD1 therapy for metastatic melanoma has finished.
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: ENB003 Plus Pembrolizumab Phase 1b/2a in Solid Tumors [Phase 1, Phase 2]
A Phase 1b/2a trial evaluating ENB003 in combination with pembrolizumab for various solid tumors, including melanoma, ovarian cancer, pancre…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: Neoadjuvant Immunotherapy of Operable Metastatic Melanoma in Real Life (GCC)
This clinical trial update indicates ongoing recruitment for a neoadjuvant immunotherapy study in operable metastatic melanoma conducted at …
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: MELCAYA - Novel Health Care Strategies for Melanoma in Children, Adolescents, and Young Adults - Work Package 3 (WP3)
Clinical trial update for MELCAYA WP3 studying novel health care strategies for melanoma in children, adolescents, and young adults; current…
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FDA approval · 2024-09-12FDA Approved: MEKTOVI — Supplemental Application (Array BioPharma Inc.)
FDA approved a supplemental application for MEKTOVI (binimetinib) submitted by Array BioPharma Inc.
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CLINICAL_TRIALS trial_result · 2024-09-05Clinical Trial Update: How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes
This clinical trial update discusses how gut microbes and metabolism may predict responses to skin cancer immunotherapy, though the study ha…
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CLINICAL_TRIALS trial_result · 2024-09-04Clinical Trial Update: Utility of Novel BRAF Test for Melanoma
A clinical trial evaluating a novel BRAF test for melanoma has completed and posted results. Results were posted on 2024-09-04.
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CLINICAL_TRIALS trial_result · 2024-08-27Clinical Trial Update: Talimogene Laherparepvec and Pembrolizumab in Treating Patients With Stage III-IV Melanoma [Phase 2]
Phase 2 trial evaluating Talimogene laherparepvec (Imlygic) in combination with pembrolizumab for advanced or unresectable melanoma, with re…
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CLINICAL_TRIALS trial_result · 2024-08-27Clinical Trial Update: Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery [Phase 3]
A Phase 3 trial comparing high-dose recombinant interferon alfa-2B or ipilimumab to pembrolizumab in patients with surgically removed stage …
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CLINICAL_TRIALS trial_result · 2024-08-23Clinical Trial Update: Safety and Efficacy of Selinexor in Combination With Pembrolizumab in Recurrent Advanced Melanoma [Phase 2]
Phase 2 trial evaluating the safety and efficacy of selinexor in combination with pembrolizumab for recurrent advanced melanoma; the study h…
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CLINICAL_TRIALS trial_result · 2024-08-22Clinical Trial Update: Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma [Phase 2]
Phase 2 trial evaluating dabrafenib and trametinib with or without hydroxychloroquine in stage IIIC or IV BRAF V600E/K melanoma; the study w…
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CLINICAL_TRIALS trial_result · 2024-08-22Clinical Trial Update: Ipilimumab and Nivolumab Followed by Adjuvant Nivolumab in Locally Advanced or Limited Metastatic Melanoma [Phase 2]
Phase 2 clinical trial update evaluating ipilimumab and nivolumab followed by adjuvant nivolumab in locally advanced or limited metastatic m…
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CLINICAL_TRIALS trial_result · 2024-08-21Clinical Trial Update: Everolimus and Vatalanib in Treating Patients With Advanced Solid Tumors [Phase 1]
Phase 1 study evaluating the combination of everolimus and vatalanib in patients with advanced solid tumors, including several neuroendocrin…
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CLINICAL_TRIALS research · 2024-08-21Clinical Trial Update: Immunotherapy and Carbon Ion Radiotherapy In Solid Cancers With Stable Disease [Phase 2]
Phase 2 clinical trial exploring immunotherapy combined with carbon ion radiotherapy in solid cancers with stable disease, currently recruit…
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CLINICAL_TRIALS trial_result · 2024-08-21Clinical Trial Update: Vaccination With Autologous, Lethally Irradiated Melanoma Cells Engineered by Adenoviral Mediated Gene Transfer to Secrete Granulocyte-Macrophage Stimulating Factor (GMSF) [Phase 1]
Phase 1 trial of autologous, lethally irradiated melanoma cells engineered by adenoviral gene transfer to secrete GM-CSF; the study has comp…
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CLINICAL_TRIALS trial_result · 2024-08-16Clinical Trial Update: Relapse-Free Survival With Adjuvant Dabrafenib/Trametinib Therapy in Patients With BRAF V600-mutated Stage III/IV Melanoma
The clinical trial update reports relapse-free survival results for adjuvant dabrafenib/trametinib in patients with BRAF V600-mutated stage …
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CLINICAL_TRIALS research · 2024-08-16Clinical Trial Update: A RC198 Study in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors [Phase 1]
RemeGen's RC198 is being evaluated in a Phase 1 study across locally advanced unresectable or metastatic solid tumors, including melanoma, u…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Docetaxel With or Without AZD6244 in Melanoma [Phase 2]
Phase 2 trial evaluating docetaxel with or without the MEK inhibitor AZD6244 in melanoma has completed, and the results have been posted.