Melanoma
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Follow Up Protocol for Subjects Previously Enrolled on NCI Surgery Branch Studies
The document provides an update to the follow-up protocol for subjects previously enrolled in NCI Surgery Branch studies. It covers follow-u…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma [Phase 2]
This document provides a status update on a Phase 2 trial evaluating lifileucel (tumor-infiltrating lymphocytes) in adults with advanced mel…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors [Phase 1]
A Phase 1 study evaluating the safety and potential early efficacy of NST-628 oral tablets in adults with solid tumors is currently recruiti…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Dabrafenib and/or Trametinib Rollover Study [Phase 4]
Phase 4 rollover study of dabrafenib and/or trametinib for melanoma and non-small cell lung cancer is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Study of CTX-471 as a Monotherapy or in Combination With Pembrolizumab in Patients Post PD-1/PD-L1 Inhibitors in Metastatic or Locally Advanced Malignancies [Phase 1]
Phase 1 trial evaluating CTX-471 as a monotherapy or in combination with pembrolizumab in patients who progressed after PD-1/PD-L1 inhibitor…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord [Phase 2]
This is a Phase 2 clinical trial update evaluating the combination of thermal ablation and spine stereotactic radiosurgery for spine metasta…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: HX009+ IN10018 With or Without Standard Chemotherapy for Advanced Solid Tumours [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating HX009 plus IN10018 with or without standard chemotherapy for advanced solid tumors, including biliary tr…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases [Phase 2]
Phase 2 clinical trial evaluating the combination of binimetinib and encorafenib for metastatic melanoma with CNS metastases is currently re…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Patient Preference for Subcutaneous vs. Intravenous Immune Therapy [Phase 2]
Phase 2 clinical trial update on patient preference for subcutaneous versus intravenous immune therapy; the study is currently recruiting ac…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Well-Being and Health-Related Quality of Life in Melanoma Patients During COVID-19 Pandemic
This clinical trial update describes a study evaluating well-being and health-related quality of life in melanoma patients during the COVID-…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma [Phase 1]
Phase I, open-label study evaluating autologous tumor-infiltrating lymphocytes engineered with membrane-bound IL-15 in adults with metastati…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Phase 1 Dose Escalation and Expansion Study of PRAME T Cell Receptor (TCR) Engineered NK Cells in Participants With Recurrent and/or Refractory Melanoma (PRAMETIME-Mel) [Phase 1]
Phase 1 dose-escalation and expansion study evaluating PRAME TCR-engineered NK cells for recurrent or refractory melanoma; currently recruit…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA) [Phase 1]
Phase Ib study investigating alpelisib in combination with pembrolizumab in metastatic breast cancer or melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Stereotactic Ablative Radiotherapy (XRT) and Immunotherapy for Oligometastatic Extracranial Melanoma [Phase 2]
Phase 2 clinical trial evaluating stereotactic ablative radiotherapy combined with immunotherapy for oligometastatic extracranial melanoma; …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study of HLX18 vs. OPDIVO® in Multiple Resected Solid Tumors [Phase 1]
Phase 1 trial comparing HLX18 to nivolumab (Opdivo) in patients with multiple resected solid tumors, including esophageal/gastric cardia can…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study in People With Advanced Cancer (Solid Tumours) to Test Different Doses of BI 3810944 and to Find Out Whether it Helps [Phase 1]
A Phase 1 study evaluating different doses of BI 3810944 in adults with advanced cancer, including melanoma, is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Genetically Modified T-Cells Followed by Aldesleukin in Treating Patients With Stage III-IV Melanoma [Phase 1]
Phase 1 trial from MD Anderson evaluating genetically modified T-cells followed by Aldesleukin in patients with stage III to IV melanoma. Th…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors [Phase 1]
Phase 1 clinical trial evaluating IACS-6274 with or without Bevacizumab and Paclitaxel in adults with advanced solid tumors; the study is cu…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: ctDNA for Risk Stratification in Melanoma
This clinical trial update describes evaluating circulating tumor DNA (ctDNA) for risk stratification in melanoma.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors [Phase 1]
Phase 1 clinical trial update for Enzelkitug as a single agent and in combination with a checkpoint inhibitor in adults with locally advance…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: NO Re-excision MelanomA - NORMA 2 [Phase 3]
NORMA 2 is a Phase 3 clinical trial in melanoma evaluating a no-reexcision strategy; the study is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Generation of an Artificial Intelligence Algorithm Based on the Analysis of Melanoma Peri-scar Dermatoheliosis, as a Predictive Factor of Response to Anti-PD-1
A recruiting clinical trial is evaluating an AI algorithm based on melanoma peri-scar dermatoheliosis as a predictive factor for response to…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Harvesting Cells for Experimental Cancer Treatments
An NCI-sponsored clinical trial update indicates enrollment by invitation for a cell-harvesting approach in experimental cancer therapies ac…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: TNF in Melanoma Patients Treated With Immunotherapy [NA]
A completed clinical trial sponsored by Institut Claudius Regaud studied tumor necrosis factor (TNF) in melanoma patients treated with immun…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Personalized Cancer Support (Thrive Track) to Manage the Emotional Needs of Young Adults With Thyroid, Melanoma and Testicular Cancer, PerCS-YA Trial [NA]
A ClinicalTrials.gov update for the Thrive Track trial aimed at managing emotional support for young adults with thyroid cancer, melanoma, a…