Melanoma
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CLINICAL_TRIALS research · 2025-04-06Clinical Trial Update: Immune Profiles Evolution Under Immunotherapy for Melanoma [NA]
This clinical trial entry describes a study in melanoma investigating how immune profiles evolve during immunotherapy. The study is currentl…
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CLINICAL_TRIALS trial_result · 2025-04-06Clinical Trial Update: A Clinical Study of the Safety and Activity of the Investigational Cell Therapy NEO-PTC-01 in Patients With Advanced Melanoma [Phase 1]
A Phase 1 study evaluating the safety and activity of BioNTech's investigational cell therapy NEO-PTC-01 in patients with unresectable or me…
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CLINICAL_TRIALS trial_result · 2025-04-04Clinical Trial Update: Head and Neck Melanoma; Access to Staging and Surgical Treatment
A completed clinical trial from Hull University Teaching Hospitals NHS Trust studied access to staging and surgical treatment for head and n…
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of IBI363 Monotherapy Compared to Pembrolizumab in Patients With Unresectable Locally Advanced or Metastatic Mucosal or Acral Melanoma Who Had Not Previously Received Systemic Therapy [Phase 2]
Phase 2 study evaluating IBI363 monotherapy versus pembrolizumab for unresectable locally advanced or metastatic mucosal or acral melanoma i…
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Study of CBL0137 in Combination With Ipilimumab and Nivolumab Therapy in Melanoma [EARLY_Phase 1]
Early-phase study evaluating CBL0137 in combination with ipilimumab and nivolumab for locally advanced or metastatic melanoma, currently rec…
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CLINICAL_TRIALS other · 2025-04-04Clinical Trial Update: A Study of Oral IRAK-4 Inhibitor CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery in Patients With Melanoma Brain Metastases [Phase 1, Phase 2]
A Phase 1/2 study of CA-4948 in combination with pembrolizumab and stereotactic radiosurgery for melanoma brain metastases is currently susp…
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Descriptive Observational Study on the Characteristics of Advanced and Metastatic Melanoma in Spain
It is an ongoing descriptive observational study in Spain focused on advanced and metastatic melanoma. Recruitment is ongoing.
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of Alomfilimab (KY1044) as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies [Phase 1, Phase 2]
Phase 1/2 open-label study evaluating Alomfilimab (KY1044) alone and with atezolizumab in multiple advanced cancers. The trial was terminate…
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: CMP-001 in Combination With Nivolumab in Subjects With Advanced Melanoma [Phase 2]
Phase 2 trial of CMP-001 in combination with nivolumab in advanced melanoma was terminated; results have been posted.
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Open Label Phase 2 Basket Trial With Atezolizumab and Tiragolumab in Solid Tumors [Phase 2]
This ClinicalTrials.gov update describes a Phase 2 open-label basket trial evaluating the combination of atezolizumab and tiragolumab in sol…
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CLINICAL_TRIALS research · 2025-03-28Clinical Trial Update: Long-term Follow-up of Checkpoint Inhibitors-induced Ileo-colitis
A clinical trial update describing long-term follow-up of immune checkpoint inhibitor–induced ileocolitis and ongoing recruitment for patien…
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CLINICAL_TRIALS trial_result · 2025-03-28Clinical Trial Update: Fecal Microbial Transplantation in Combination With Immunotherapy in Melanoma Patients (MIMic) [Phase 1]
A Phase 1 clinical trial evaluating fecal microbiota transplantation in combination with immunotherapy for melanoma; the study is currently …
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: XmAb23104 (PD1 X ICOS) and XmAb22841 (CTLA-4 X LAG3) in Treating Melanoma Prior Immune Checkpoint Inhibitor Therapy [Phase 1]
Phase 1 trial evaluating XmAb23104 (PD1 X ICOS) and XmAb22841 (CTLA-4 X LAG3) for metastatic or advanced melanoma in patients previously tre…
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CLINICAL_TRIALS research · 2025-03-26Clinical Trial Update: Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients [Phase 2]
Phase 2 clinical trial update on Voyager V1 in combination with cemiplimab in cancer patients, with conditions including melanoma, head and …
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CLINICAL_TRIALS research · 2025-03-26Clinical Trial Update: Single-Center Trial on Ketogenic Diet and Immunotherapy in Advanced Cancer This Study Evaluates the Safety and Effects of a Ketogenic Diet (KD) Combined With Immunotherapy in Adults With Advanced Melanoma, cSCC, or RCC. [Phase 1, Phase 2]
A single-center Phase 1/2 trial is evaluating the safety and effects of combining a ketogenic diet with immunotherapy in adults with advance…
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CLINICAL_TRIALS research · 2025-03-26Clinical Trial Update: Intratumoral Targeted Hyperthermia Therapy (THT) for Stage 3C/3D/4M1 Cutaneous Metastatic Melanoma [NA]
This ClinicalTrials.gov entry describes a trial evaluating intratumoral targeted hyperthermia therapy (THT) for stage 3C/3D/4M1 cutaneous me…
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CLINICAL_TRIALS trial_result · 2025-03-21Clinical Trial Update: Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors [Phase 2]
Phase 2 study evaluating the efficacy of tislelizumab and spartalizumab across multiple cancers with PD-1 high mRNA expression; the trial is…
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CLINICAL_TRIALS trial_result · 2025-03-21Clinical Trial Update: Oral STAT3 Inhibitor, TTI-101, in Patients With Advanced Cancers [Phase 1]
Phase 1 study of the oral STAT3 inhibitor TTI-101 in patients with advanced cancers has completed, with enrollment across multiple tumor typ…
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC) [Phase 1, Phase 2]
A Phase 1b/2 dose-escalation trial of entinostat with pembrolizumab in non-small cell lung cancer, with expansion cohorts in melanoma and co…
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Nous-PEV: a Novel Immunotherapy for Lung Cancer and Melanoma [Phase 1]
Phase 1 study of Nous-PEV for melanoma and non-small cell lung cancer has been terminated.
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FDA approval · 2025-03-19FDA Approved: TAFINLAR — Supplemental Application (Novartis Pharmaceuticals Corporation)
The FDA approved a supplemental application for TAFINLAR (dabrafenib) from Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS other · 2025-03-19Clinical Trial Update: Interim FDG PET-CT in Melanoma Metastatic Patient's Treated by Anti-PD1 Therapy [NA]
The document reports an interim imaging-focused update on a trial of anti-PD-1 therapy in metastatic melanoma, noting ongoing recruitment an…
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Perioperative Treatment With Tranexamic Acid in Melanoma [Phase 3]
This document details a Phase 3 clinical trial evaluating perioperative tranexamic acid in patients with melanoma that is currently recruiti…
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Real-life Pharmacological Monitoring of Encorafenib-Binimetinib in the Treatment of Metastatic Melanoma
A real-world pharmacological monitoring study of the encorafenib and binimetinib combination for metastatic melanoma is currently recruiting…
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CLINICAL_TRIALS trial_result · 2025-03-14Clinical Trial Update: SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas [Phase 1]
Phase 1 trial evaluating SL-279252, a PD-1-Fc-OX40L fusion protein, in adults with advanced solid tumors or lymphomas has been completed wit…