Melanoma
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CLINICAL_TRIALS trial_result · 2025-12-17Clinical Trial Update: Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients [Phase 3]
A Phase 3 neoadjuvant intratumoral treatment with Daromun is being studied in patients with clinical stage IIIB/IIIC/IIID melanoma, with rec…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Neoadjuvant Dabrafenib + Trametinib for AJCC Stage IIIB-C BRAF V600 Mutation Positive Melanoma [Phase 2]
This document provides an update on a Phase 2 neoadjuvant trial of dabrafenib plus trametinib for AJCC Stage IIIB-C BRAF V600 mutation-posit…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body [Phase 1, Phase 2]
First-in-human Phase 1/2 trial evaluating REGN10597 alone or with cemiplimab in adults with melanoma, clear-cell renal cell carcinoma, and o…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: A Study to Investigate the Novel Agent BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Advanced Melanoma That Has Not Responded to Other Forms of Treatment [Phase 2]
A Phase 2 study evaluating BNT111 in combination with cemiplimab, or as single agents, in patients with advanced or unresectable melanoma th…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: Prognostic and Treatment-Response Factors in Metastatic Melanoma: Multi-Center Analysis
This completed, multi-center analysis examines prognostic factors and treatment-response indicators in metastatic melanoma.
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN Loss [Phase 1, Phase 2]
Status update on a Phase 1/2 study of the selective PI3K-β inhibitor GSK2636771 in combination with pembrolizumab for metastatic melanoma wi…
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: Adjuvant Dabrafenib and Trametinib Treatment in Patients With Completely Resected High-risk Stage III Melanoma.
This document provides an update on a completed clinical trial evaluating adjuvant dabrafenib and trametinib in patients with completely res…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Prospective Collection of Clinical Data and Human Body Material (HBM) of Cutaneous Melanoma and Non Melanoma Patients. Biobank Huidkanker
Prospective collection of clinical data and human body material from patients with cutaneous melanoma and non-melanoma skin cancer for bioba…
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CLINICAL_TRIALS other · 2025-12-12Clinical Trial Update: SWE-NEO: Swedish NeoAdjuvant Trial Comparing Monotherapy to Combined Immunotherapy in Resectable Stage III Melanoma [Phase 3]
A Phase 3 trial in Sweden (SWE-NEO) evaluating monotherapy versus combination immunotherapy for resectable Stage III melanoma; the study is …
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CLINICAL_TRIALS trial_result · 2025-12-11Clinical Trial Update: Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors [Phase 3]
Phase 3 trial evaluating the duration of PD-1/PD-L1 inhibitor therapy in advanced solid tumors; the study has completed.
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: Reflectance Confocal Microscopy and Molecular Correlation in Atypical Melanocytic Lesions
Clinical trial evaluating reflectance confocal microscopy with molecular correlation and sequencing data to study atypical melanocytic lesio…
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer [Phase 3]
Phase 3 clinical trial evaluating immunotherapy or targeted therapy with or without stereotactic radiosurgery for brain metastases in patien…
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: A Study of GC101 TIL in Advanced Melanoma (10hospital) [EARLY_Phase 1]
An early-phase study evaluating GC101 Tumor Infiltrating Lymphocytes (TIL) for advanced melanoma is listed as recruiting, sponsored by Shang…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Anti-PD 1 Brain Collaboration for Patients With Melanoma Brain Metastases [Phase 2]
Phase 2 clinical trial update on an anti-PD-1 therapy for melanoma with brain metastases; the study is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-09Clinical Trial Update: Study of Lifileucel (LN-144), Autologous Tumor Infiltrating Lymphocytes, in the Treatment of Patients With Metastatic Melanoma [Phase 2]
Phase 2 results update for lifileucel (LN-144), autologous tumor-infiltrating lymphocytes, in patients with metastatic melanoma; results fro…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Oral Decitabine/Cedazuridine (DEC-C) in Combination With Nivolumab for Patients With Mucosal Melanoma [Phase 1, Phase 2]
Clinical trial update describes a Phase 1/2 study of oral decitabine/cedazuridine (DEC-C) in combination with nivolumab for patients with mu…
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CLINICAL_TRIALS trial_result · 2025-12-08Clinical Trial Update: Pembrolizumab and EDP1503 in Advanced Melanoma [Phase 2]
Phase 2 trial of pembrolizumab in combination with EDP1503 for advanced melanoma was terminated, with results posted.
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study [NA]
A pilot PET imaging trial using the 124I-labeled humanized antibody 3F8 to visualize solid tumors, including melanoma, neuroblastoma, and sa…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: A Trial of LBL-024 Monotherapy, LBL-024 Combined With LBL-007 or Toripalimab in Patients With Advanced Melanoma [Phase 1, Phase 2]
A Phase 1/2 trial is evaluating LBL-024 as monotherapy and in combination with LBL-007 or Toripalimab in patients with advanced melanoma. Th…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Axitinib + Ipilimumab in Advanced Melanoma [Phase 2]
Phase 2 clinical trial evaluating axitinib plus ipilimumab in advanced melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942) [Phase 2]
This Phase 2 trial evaluates adjuvant therapy with Moderna's personalized cancer vaccine mRNA-4157 in combination with pembrolizumab for hig…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating the safety and efficacy of IOV-3001 in adults with advanced melanoma who will receive lifileucel; t…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Clear Me: Interception Trial to Detect and Clear Molecular Residual Disease in Patients With High-risk Melanoma [Phase 2]
A Phase 2 trial named Clear Me aims to detect and clear molecular residual disease in high-risk melanoma and is currently recruiting, includ…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: VSV-02 Compassionate Use in Advanced Solid Tumors [Phase 1]
Phase 1 trial update indicates compassionate-use testing of VSV-02 for advanced solid tumors, including melanoma, with recruitment ongoing a…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors [Phase 1]
Phase 1 study of TBI-1301, an NY-ESO-1–specific TCR gene-transduced autologous T cell therapy, in solid tumors; the trial is currently activ…