Malignant Solid Tumor
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CLINICAL_TRIALS trial_result · 2026-08-11Clinical Trial Results: Trial to Assess the Safety and Preliminary Efficacy of GEN1055 on Malignant Solid Tumors as Monotherapy and as Combination Therapy [Phase 1, Phase 2]
Phase 1/2 trial evaluating GEN1055 as monotherapy and in combination for malignant solid tumors has been terminated; results posted.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial) [Phase 2]
Phase 2 ComboMATCH trial evaluating AMG 510 (sotorasib) with panitumumab for KRAS G12C-mutant solid tumors; currently active but not recruit…
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CLINICAL_TRIALS other · 2026-04-15Clinical Trial Update: Assessment of Verbal Comprehension and Cognitive Processes in Patients Admitted to the Palliative and Supportive Care Unit
A clinical trial at M.D. Anderson Cancer Center evaluating verbal comprehension and cognitive processes in cancer patients admitted to a pal…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Studying TAK-243 in Patients With Advanced Cancer [Phase 1]
This entry describes a Phase 1 clinical trial evaluating TAK-243 in adults with advanced cancers, including non-Hodgkin lymphoma and various…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer [Phase 1]
This clinical trial update describes a Phase 1 study investigating the combination of trastuzumab deruxtecan (DS-8201a) and olaparib in HER2…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors [Phase 1]
Phase 1 clinical trial evaluating the safety and potential efficacy of combining ZEN003694 with abemaciclib in adults and 12-17-year-old ped…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Combination of ZEN003694 and Nivolumab With or Without Ipilimumab in Solid Tumors [Phase 1]
Phase 1 clinical trial evaluating the combination of ZEN003694 with nivolumab, with or without ipilimumab, in metastatic and recurrent solid…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Combination of Copanlisib, Nivolumab and Ipilimumab in Patients With Advanced Cancer and Lymphoma [Phase 1]
A Phase 1 clinical trial is evaluating the three-drug combination of Copanlisib, Nivolumab, and Ipilimumab in patients with advanced cancer …
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors [Phase 1, Phase 2]
GEN1042 is being evaluated in a Phase 1/2 safety study with indications across malignant solid tumors, including non-small cell lung cancer,…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Safety Trial of GEN1042 in Japanese Subjects With Malignant Solid Tumors [Phase 1]
Clinical trial update detailing a Phase 1 safety study of GEN1042 in Japanese subjects with malignant solid tumors, currently active but not…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer [Phase 3]
Phase 3 clinical trial evaluating triptorelin to prevent chemotherapy-induced ovarian damage in adolescents and young adults with cancer is …
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors [Phase 1]
This update notes that ISM6331 is being studied in a Phase 1 trial with recruitment ongoing for participants with malignant mesothelioma and…
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CLINICAL_TRIALS trial_result · 2025-12-26Clinical Trial Update: Trial to Assess the Safety and Preliminary Efficacy of GEN1055 on Malignant Solid Tumors as Monotherapy and as Combination Therapy [Phase 1, Phase 2]
The Phase 1/2 trial evaluating the safety and preliminary efficacy of GEN1055 in malignant solid tumors (as monotherapy and in combination) …
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I) [Phase 2]
Phase 2 MATCH subprotocol Z1I study evaluating AZD1775 (adavosertib) as a targeted treatment for cancers with BRCA genetic changes. The tria…
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CLINICAL_TRIALS trial_result · 2025-08-26Clinical Trial Update: Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K) [Phase 2]
This Clinical Trial Update reports that ipatasertib is being tested as a targeted therapy for cancers with AKT genetic alterations in the NC…
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CLINICAL_TRIALS trial_result · 2025-01-08Clinical Trial Update: An Investigational Scan (7T MRI) for the Imaging of Central Nervous System Tumors [NA]
This ClinicalTrials.gov update reports completion of an investigational 7T MRI imaging study for central nervous system tumors, with results…
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CLINICAL_TRIALS research · 2024-11-07Clinical Trial Update: Assessment of the Safety and Tolerability of ex Vivo Next-generation Neoantigen-selected Tumor-infiltrating Lymphocyte (TIL) Therapy in Advanced Epithelial Tumors and Immune Checkpoint Blockade (ICB) Resistant Solid Tumors [EARLY_Phase 1]
An early-phase trial is evaluating the safety and tolerability of ex vivo next-generation neoantigen-selected tumor-infiltrating lymphocyte …
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CLINICAL_TRIALS trial_result · 2024-10-29Clinical Trial Update: Viral Specific T Cell Therapy for COVID-19 Related Pneumonia [EARLY_Phase 1]
An early Phase 1 trial of viral-specific T cell therapy for COVID-19-related pneumonia has completed, evaluating safety and feasibility in p…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: To Evaluate the Phase I Clinical Study of JSKN016 in Chinese Patients With Advanced Malignant Solid Tumors [Phase 1]
This clinical trial update announces the Phase I study of JSKN016 in Chinese patients with advanced malignant solid tumors and indicates rec…
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CLINICAL_TRIALS trial_result · 2024-04-25Clinical Trial Update: Methoxyamine, Cisplatin, and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors or Mesothelioma That Cannot Be Removed by Surgery or Mesothelioma That Is Refractory to Pemetrexed Disodium and Cisplatin or Carboplatin [Phase 1, Phase 2]
Phase 1/2 trial evaluating the combination of methoxyamine with cisplatin and pemetrexed disodium in patients with advanced solid tumors or …
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CLINICAL_TRIALS trial_result · 2023-07-19Clinical Trial Update: A Clinical Trial to Evaluate the Effect of IAE0972 in Patients With Advanced Malignant Solid Tumors. [Phase 1, Phase 2]
A first-in-human trial update evaluating IAE0972 in patients with advanced malignant solid tumors (Phase 1/2).
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CLINICAL_TRIALS trial_result · 2023-06-18Clinical Trial Update: An Open-Label, Multicenter, Phase 1/2 Study of Poly(ADP-Ribose) Polymerase (PARP) Inhibitor E7449 as Single Agent in Subjects With Advanced Solid Tumors or With B-cell Malignancies and in Combination With Temozolomide (TMZ) or With Carboplatin and Paclitaxel in Subjects With Advanced Solid Tumors [Phase 1, Phase 2]
Open-label, multicenter Phase 1/2 trial evaluating PARP inhibitor E7449 as a single agent and in combination regimens for advanced solid tum…
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CLINICAL_TRIALS trial_result · 2023-04-12Clinical Trial Update: A Clinical Study to Observe the Safety and Efficacy of ScTIL210 in the Treatment of Malignant Solid Tumors [Phase 1, Phase 2]
A clinical trial update for ScTIL210 assessing safety and efficacy in malignant solid tumors (Phase 1/Phase 2).
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CLINICAL_TRIALS trial_result · 2023-04-05Clinical Trial Update: An Investigational Immuno-therapy Study of Experimental Medication BMS-986179 Given Alone and in Combination With Nivolumab [Phase 1, Phase 2]
Phase 1/2 trial update for experimental immunotherapy BMS-986179, studied alone and with nivolumab, in malignant solid tumors; results poste…
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CLINICAL_TRIALS trial_result · 2022-05-09Clinical Trial Update: Clinical Research on Comprehensive Treatment of Tuberculosis With Malignant Solid Tumor [Phase 1, Phase 2]
Clinical trial update reporting phase 1/2 study on comprehensive treatment for malignant solid tumors; the study is completed.