Malignant Pleural Mesothelioma
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CLINICAL_TRIALS research · 2025-03-20Clinical Trial Update: Genetic Susceptibility in MAlignant Pleural Mesothelioma: Clinical Implication of GermliNE variaTionS
This document provides an update on a clinical trial investigating genetic susceptibility in malignant pleural mesothelioma and the clinical…
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CLINICAL_TRIALS trial_result · 2025-03-13Clinical Trial Update: Multicenter Single-Arm Study of Ivonescimab (AK112) Combined with Chemotherapy in Pretreated Pleural Mesothelioma [Phase 2]
Phase 2 multicenter single-arm trial evaluating Ivonescimab (AK112) plus chemotherapy for pretreatment malignant pleural mesothelioma; the s…
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CLINICAL_TRIALS research · 2025-03-13Clinical Trial Update: Atezolizumab Versus Placebo for the Adjuvant Treatment of Malignant Pleural Mesothelioma (Atezomeso) [Phase 3]
This is a Phase 3 clinical trial evaluating atezolizumab versus placebo as adjuvant therapy for malignant pleural mesothelioma, currently re…
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CLINICAL_TRIALS trial_result · 2025-02-19Clinical Trial Update: Testing the Addition of Targeted Radiation Therapy to Surgery and the Usual Chemotherapy Treatment (Pemetrexed and Cisplatin [or Carboplatin]) for Stage I-IIIA Malignant Pleural Mesothelioma [Phase 3]
A Phase 3 trial testing the addition of targeted radiation therapy to surgery and standard pemetrexed plus cisplatin or carboplatin chemothe…
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CLINICAL_TRIALS trial_result · 2025-02-06Clinical Trial Update: Nivolumab With Chemotherapy in Pleural Mesothelioma After Surgery [Phase 2]
A Phase 2 trial evaluating nivolumab in combination with chemotherapy after surgical resection in malignant pleural mesothelioma has complet…
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CLINICAL_TRIALS trial_result · 2025-01-20Clinical Trial Update: A Study of Yervoy and Opdivo Combination Therapy in Participants With Unresectable Advanced/Recurrent Malignant Pleural Mesothelioma (MPM)
Clinical trial evaluating the combination of Yervoy (ipilimumab) and Opdivo (nivolumab) in unresectable advanced or recurrent malignant pleu…
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CLINICAL_TRIALS trial_result · 2025-01-13Clinical Trial Update: Staging Procedures to Diagnose Malignant Pleural Mesothelioma
The Mayo Clinic-sponsored trial evaluating staging procedures to diagnose malignant pleural mesothelioma has been terminated.
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CLINICAL_TRIALS trial_result · 2024-12-10Clinical Trial Update: Pembrolizumab in Patients With Advanced Malignant Pleural Mesothelioma [Phase 2, Phase 3]
This document reports the completion and posted results from a Phase 2/3 clinical trial evaluating pembrolizumab in patients with advanced m…
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CLINICAL_TRIALS trial_result · 2024-11-18Clinical Trial Update: Oral TEAD Inhibitor Targeting the Hippo Pathway in Subjects with Advanced Solid Tumors [Phase 1]
Phase 1 study of an oral TEAD inhibitor from Ikena Oncology in adults with advanced solid tumors has been terminated. The trial included pat…
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FDA approval · 2024-11-15FDA Approved: PEMRYDI RTU — Supplemental Application (Amneal Pharmaceuticals LLC)
The FDA approved a supplemental application for PEMRYDI RTU, a ready-to-use formulation of pemetrexed disodium, developed by Amneal Pharmace…
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CLINICAL_TRIALS research · 2024-11-05Clinical Trial Update: Pembrolizumab Plus Lenvatinib In Second Line and Third Line Malignant Pleural mesotheLioma Patients [Phase 2]
This is a Phase 2 clinical trial assessing pembrolizumab plus lenvatinib in second- and third-line malignant pleural mesothelioma, with the …
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CLINICAL_TRIALS trial_result · 2024-10-23Clinical Trial Update: Alvopem® (Pemetrexed) Safety Assessment
Safety data from completed trials of Alvopem (pemetrexed) have been assessed and results are now posted.
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CLINICAL_TRIALS trial_result · 2024-10-16Clinical Trial Update: Pembrolizumab With or Without Anetumab Ravtansine in Treating Patients With Mesothelin-Positive Pleural Mesothelioma [Phase 1, Phase 2]
This update reports results from a Phase 1/2 study of pembrolizumab with or without the mesothelin-targeting antibody-drug conjugate anetuma…
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: Identification of Prognostic and Predictive Biomarkers of Toxicity in Patients With Malignant Pleural Mesothelioma and Treated With High Doses of Radiotherapy (MESORTIBO)
A clinical trial (MESORTIBO) investigating prognostic and predictive biomarkers of toxicity in patients with malignant pleural mesothelioma …
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: Galinpepimut-S (WT-1 Analog Peptide) Vaccine in Malignant Pleural Mesothelioma After Combined Modality Therapy [Phase 2]
Phase 2 clinical trial update evaluating the Galinpepimut-S WT-1 peptide vaccine in Malignant Pleural Mesothelioma after combined modality t…
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CLINICAL_TRIALS trial_result · 2024-08-27Clinical Trial Update: Switch-Maintenance Gemcitabine After First-Line Chemotherapy In Patients With Malignant Pleural Mesothelioma [Phase 2]
A Phase 2 clinical trial evaluating switch-maintenance gemcitabine after first-line chemotherapy in malignant pleural mesothelioma has compl…
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CLINICAL_TRIALS trial_result · 2024-07-31Clinical Trial Update: A Pilot Window-Of-Opportunity Study of the Anti-PD-1 Antibody Pembrolizumab in Patients With Resectable Malignant Pleural Mesothelioma [Phase 1]
This clinical trial update documents a Phase 1 window-of-opportunity study of pembrolizumab in patients with resectable malignant pleural me…
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CLINICAL_TRIALS trial_result · 2024-07-30Clinical Trial Update: Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma
The clinical trial NCT02613312 evaluating chemotherapy followed by surgery and neoadjuvant hemithoracic IMRT for malignant pleural mesotheli…
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CLINICAL_TRIALS trial_result · 2024-07-01Clinical Trial Update: SAKK 17/18 (ORIGIN) MPM & NSCLC >1st Line Gemci & Atezo Ph II [Phase 2]
Phase II ORIGIN trial (SAKK 17/18) evaluating first-line gemcitabine with atezolizumab in malignant pleural mesothelioma and non-small cell …
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FDA approval · 2024-06-28FDA Approved: AXTLE — Original Application (Avyxa Pharma, LLC)
FDA approved the original application for AXTLE (pemetrexed) by Avyxa Pharma, LLC, for treatment of malignant pleural mesothelioma and non-s…
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FDA approval · 2024-06-14FDA Approved: PEMETREXED — Original Application (Camber Pharmaceuticals, Inc.)
FDA approved Camber Pharmaceuticals' original application for a generic pemetrexed disodium, enabling manufacturing and marketing of this ge…
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CLINICAL_TRIALS research · 2024-06-11Clinical Trial Update: Ga-68 FAPI PET Before Immunotherapy [NA]
This is an administrative update on a clinical trial sponsored by Ankara University assessing Ga-68 FAPI PET imaging before immunotherapy fo…
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CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: Integration of the PD-L1 Inhibitor Atezolizumab and WT1/DC Vaccination Into Platinum/Pemetrexed-based First-line Treatment for Epithelioid Malignant Pleural Mesothelioma [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating the combination of atezolizumab and WT1 dendritic cell vaccination with platinum/pemetrexed-based f…
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CLINICAL_TRIALS trial_result · 2024-03-22Clinical Trial Update: A Study of Pembrolizumab in Combination With Cisplatin and Pemetrexed in Advanced Malignant Pleural Mesothelioma (MPM) (MK-3475-A17) [Phase 1]
Phase 1 study of pembrolizumab in combination with cisplatin and pemetrexed for advanced malignant pleural mesothelioma has completed, with …
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CLINICAL_TRIALS trial_result · 2024-03-05Clinical Trial Update: Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma [Phase 1]
Phase 1 trial evaluating atezolizumab with pemetrexed disodium and cisplatin, followed by surgery with or without radiation, for Stage I–III…