Malignant Pleural Effusion
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion [Phase 1]
This document reports a Phase Ib study of JMKX000197 injection for malignant pleural effusion that is currently recruiting.
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CLINICAL_TRIALS research · 2025-03-28Clinical Trial Update: Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion [NA]
The University of Hong Kong-sponsored trial comparing different sizes of small-bore chest drains for malignant pleural effusion in stage IV …
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: Rapid On Site Evaluation of Pleural Touch Preparations in Diagnosing Malignant Pleural Effusion in Patients Undergoing Pleuroscopy [NA]
MD Anderson's NCT03868579 evaluated rapid on-site evaluation of pleural touch preparations during pleuroscopy to diagnose malignant pleural …
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CLINICAL_TRIALS trial_result · 2024-12-20Clinical Trial Update: Thoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural Effusion [Phase 4]
A Phase 4 study comparing thoracoscopic talc pleurodesis versus a bleomycin-tranexamic acid mixture injected via chest tube for malignant pl…
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CLINICAL_TRIALS trial_result · 2024-12-19Clinical Trial Update: The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural Effusion [EARLY_Phase 1]
The document reports an early-phase trial update on the outcome of inserting an intercostal tube or performing pleurodesis to treat malignan…
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CLINICAL_TRIALS trial_result · 2024-12-12Clinical Trial Update: Quantitative C-Reactive Protein for Differentiating Tuberculous and Malignant Pleural Effusion: a Cross-Sectional Study
This cross-sectional study evaluated whether quantitative C-reactive protein can differentiate tuberculous pleural effusion from malignant p…
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CLINICAL_TRIALS research · 2024-12-10Clinical Trial Update: A Study of MT027 in Patients with Pleural Malignant Tumors [Phase 1]
Phase 1 clinical trial evaluating MT027 in patients with pleural malignant tumors, currently recruiting.
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CLINICAL_TRIALS research · 2024-11-26Clinical Trial Update: Pleural Carcinomatosis Tissue Banking
Enrollment is underway for a pleural tissue banking study focused on malignant pleural effusion. The update does not report results or effic…
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CLINICAL_TRIALS research · 2024-11-15Clinical Trial Update: Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion [NA]
A clinical trial comparing pleural bleomycin treatment against mechanical abrasion for malignant pleural effusion; the study is not yet recr…
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CLINICAL_TRIALS research · 2024-11-12Clinical Trial Update: Feasibility of Ambulatory Talc. Pleurodesis [NA]
This clinical trial update describes the feasibility of ambulatory talc pleurodesis for malignant pleural effusion and indicates the study i…
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CLINICAL_TRIALS research · 2024-10-30Clinical Trial Update: Dual-targeting HER2 and PD-L1 CAR-T for Solid Tumors [EARLY_Phase 1]
An early-phase (Phase 1) trial is evaluating a dual-targeting CAR-T therapy against HER2 and PD-L1 for solid tumors, including metastatic pe…
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CLINICAL_TRIALS research · 2024-07-22Clinical Trial Update: Clinical Study on Intraluminal Injection of FOLactis [NA]
A recruiting clinical study is evaluating intraluminal injection of FOLactis for solid tumors, including malignant pleural effusion and peri…
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CLINICAL_TRIALS research · 2024-05-20Clinical Trial Update: OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion. [Phase 1]
A Phase 1 clinical trial evaluating OPC5 delivered as a pressurized intrathoracic aerosol chemotherapy (PITAC) for malignant pleural effusio…
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CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites [Phase 1]
A Phase 1 clinical trial is investigating interferon-gamma combined with T cells for refractory malignant pleural effusion (and ascites) and…
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CLINICAL_TRIALS trial_result · 2024-01-26Clinical Trial Update: Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma [Phase 1, Phase 2]
A clinical trial update for RSO-021 in malignant pleural effusion due to advanced/metastatic solid tumors including mesothelioma across Phas…
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CLINICAL_TRIALS trial_result · 2023-09-28Clinical Trial Update: Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion [Phase 4]
Phase 4 randomized trial evaluating talc instillation plus daily drainage via tunneled pleural catheter for outpatient pleurodesis in malign…
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CLINICAL_TRIALS trial_result · 2023-06-22Clinical Trial Update: Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions [Phase 3]
Phase 3 trial investigating bleomycin, doxycycline, or talc for treating malignant pleural effusions has completed.
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CLINICAL_TRIALS trial_result · 2022-09-02Clinical Trial Update: Tunneled Pleural Catheter in Partially Entrapped Lung [Phase 2]
Phase 2 clinical trial update evaluating a tunneled pleural catheter in patients with malignant pleural effusion.
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CLINICAL_TRIALS trial_result · 2022-04-15Clinical Trial Update: A Study of Intrapleural Administration of Bevacizumab and Camrelizumab for Malignant Pleural Effusion [Phase 1, Phase 2]
A combined Phase 1/2 clinical trial evaluating intrapleural administration of bevacizumab and camrelizumab for malignant pleural effusion is…
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CLINICAL_TRIALS trial_result · 2021-04-20Clinical Trial Update: A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion [Phase 1, Phase 2]
Phase 1/2 trial of nivolumab plus intrapleural talimogene laherparepvec for malignant pleural effusion has been terminated with results post…
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CLINICAL_TRIALS trial_result · 2020-09-25Clinical Trial Update: Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population [Phase 2]
A Phase 2 clinical trial evaluating the effectiveness of doxycycline for treating malignant pleural effusions in an outpatient population.
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CLINICAL_TRIALS trial_result · 2020-08-13Clinical Trial Update: Safety and Effectiveness of a New Pleural Catheter for Symptomatic, Recurrent, MPEs Versus Approved Pleural Catheter [NA]
A completed clinical trial evaluated a new pleural catheter for symptomatic, recurrent malignant pleural effusions against an approved cathe…
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CLINICAL_TRIALS trial_result · 2020-01-23Clinical Trial Update: Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion [Phase 3]
Phase 3 trial comparing iodopovidone to talc for palliation in malignant pleural effusion has completed.
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CLINICAL_TRIALS trial_result · 2019-07-26Clinical Trial Update: Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis [Phase 4]
Phase 4 trial comparing doxycycline versus saline for pleurodesis via indwelling pleural catheter in patients with malignant pleural effusio…
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CLINICAL_TRIALS trial_result · 2019-06-14Clinical Trial Update: A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC [Phase 2]
A Phase 2 randomized study evaluating primary tumor radiotherapy for patients with malignant pleural effusion in stage IV non-small cell lun…