Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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FDA approval · 2025-06-24FDA Approved: NEFAZODONE HYDROCHLORIDE — Supplemental Application (Teva Pharmaceuticals USA, Inc.)
The FDA approved a supplemental application for nefazodone hydrochloride (Teva Pharmaceuticals USA, Inc.) to modify aspects of the product u…
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FDA approval · 2025-06-24FDA Approved: TRAZODONE HYDROCHLORIDE — Supplemental Application (Apotex Corp)
The FDA approved a supplemental application for trazodone hydrochloride from Apotex Corp, authorizing updated or additional approval details…
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FDA approval · 2025-06-24FDA Approved: TRAZODONE HYDROCHLORIDE — Supplemental Application (Accord Healthcare, Inc.)
The FDA approved a supplemental application for trazodone hydrochloride tablets from Accord Healthcare, Inc., effectively approving a generi…
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FDA approval · 2025-06-24FDA Approved: TRAZODONE HYDROCHLORIDE — Supplemental Application (Apotex Corp)
FDA approved Apotex Corp's supplemental application for trazodone hydrochloride, confirming a generic version of the antidepressant.
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity [NA]
This clinical trial update describes a study underway to test an integrated physical activity and mental health intervention for veterans wi…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Mobile CBT for Middle Aged and Older Adults [NA]
This clinical trial update notes that a mobile cognitive behavioral therapy program for anxiety and depressive symptoms is currently recruit…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Theta-Burst Stimulation to Treat Depression [Phase 1]
This document reports an ongoing Phase 1 clinical trial evaluating theta-burst stimulation as a treatment for major depressive disorder. The…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Efficacy of kTMP, a Novel Non-invasive Brain Stimulation Method, for the Treatment of Anhedonia [NA]
A clinical trial update describes evaluating kTMP, a non-invasive brain stimulation method developed by Magnetic Tides, for the treatment of…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Imaging mGluR5 and Synaptic Density in Psychiatric Disorders
A Yale University clinical trial is evaluating imaging of metabotropic glutamate receptor 5 (mGluR5) and synaptic density in Major Depressiv…
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FDA approval · 2025-06-24FDA Approved: AMITRIPTYLINE HYDROCHLORIDE — Supplemental Application (Sandoz Inc)
FDA approved a supplemental application for Amitriptyline hydrochloride from Sandoz Inc under an Abbreviated New Drug Application (ANDA).
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Neuro-computational Study of Thymic Fluctuations in Mood Disorders [NA]
Clinical trial update for a neuro-computational study of thymic fluctuations in mood disorders, currently recruiting at Centre Hospitalier S…
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FDA approval · 2025-06-24FDA Approved: TRAZODONE HYDROCHLORIDE — Supplemental Application (Sun Pharmaceutical Industries, Inc.)
The FDA approved a supplemental application for trazodone hydrochloride from Sun Pharmaceutical Industries, Inc., enabling a generic version…
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FDA approval · 2025-06-24FDA Approved: AMITRIPTYLINE HYDROCHLORIDE — Supplemental Application (Aurobindo Pharma Limited)
FDA approved a supplemental application for Amitriptyline Hydrochloride from Aurobindo Pharma Limited, authorizing a generic product's appro…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa [NA]
This clinical trial update notes ongoing recruitment for a study in Cape Town aimed at reducing psychological barriers to PrEP persistence a…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Stratified Pharmacological Approaches for Regulating Circuit-Level Effects [Phase 2]
Phase 2 clinical trial exploring stratified pharmacological approaches to regulate circuit-level effects in Major depressive disorder; curre…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: A Cohort Study of Disease Prediction Model for High-risk Population With Bipolar Disorder
This document notes a cohort study developing a disease-prediction model for a high-risk population with bipolar disorder, currently recruit…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies [NA]
A completed clinical trial explored adding positive affect-promoting activities to cognitive behavioral therapy for depression and borderlin…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: Optimal Electrical Stimulus During Electroconvulsive Therapy [Phase 4]
Phase 4 clinical trial investigating the optimal electrical stimulus during electroconvulsive therapy for major depressive disorder and bipo…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: Reducing Stigma Among Healthcare Providers (RESHAPE-cRCT) [NA]
A completed randomized controlled trial (RESHAPE-cRCT) sponsored by George Washington University evaluating a program to reduce stigma among…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: RCT: the Effectiveness of LifeHack in Improving Mental Wellbeing in University Students. [NA]
An ongoing randomized controlled trial evaluating the LifeHack internet-based intervention to improve mental wellbeing among university stud…
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CLINICAL_TRIALS trial_result · 2025-06-19Clinical Trial Update: Project QUIT+: Adapting and Testing a Smoking Cessation Intervention for Transgender and Gender Expansive Individuals [NA]
Project QUIT+, a trial adapting a smoking cessation intervention for transgender and gender expansive individuals, has been terminated. The …
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CLINICAL_TRIALS trial_result · 2025-06-19Clinical Trial Update: Amygdala TIS for Depression [NA]
A completed clinical trial evaluated amygdala-targeted transcranial stimulation for major depressive disorder.
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: Evaluating the Role of IL-17 as an Orchestrator of Peripheral-central Cross Talk in Depressive Symptoms
This clinical trial investigates whether interleukin-17 (IL-17) acts as an orchestrator between peripheral inflammation and depressive sympt…
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method [NA]
Georgetown University is conducting a clinical trial to evaluate mindful self-compassion for anxiety and depression and to compare delivery …
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FDA approval · 2025-06-18FDA Approved: TRAZODONE HYDROCHLORIDE — Supplemental Application (Torrent Pharmaceuticals Limited)
FDA approved a supplemental application for trazodone hydrochloride from Torrent Pharmaceuticals Limited, bringing the generic product into …