Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-06-23Clinical Trial Results: Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response [NA]
Clinical trial results on transdiagnostic brain-behavior profiling to enhance CBT response, completed with results posted in 2026.
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CLINICAL_TRIALS trial_result · 2026-06-17Clinical Trial Results: Neuromodulation for Comorbid Hoarding Disorder and Depression [NA]
Clinical trial results on neuromodulation for comorbid hoarding disorder and depression have been completed with results posted.
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CLINICAL_TRIALS trial_result · 2026-06-17Clinical Trial Results: Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression [NA]
Clinical trial results on modulating repetitive negative thinking related brain networks in young adults with depression; study TERMINATED w…
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CLINICAL_TRIALS trial_result · 2026-06-09Clinical Trial Update: Study to Assess the Safety and Effectiveness of NMRA-335140-501 [Phase 3]
Phase 3 clinical trial update for NMRA-335140-501 assessing safety and effectiveness in Major Depressive Disorder.
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CLINICAL_TRIALS trial_result · 2026-06-08Clinical Trial Results: A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure [Phase 3]
Phase 3 trial evaluating aticaprant plus antidepressant to prevent return of depressive symptoms in adults with Major Depressive Disorder an…
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CLINICAL_TRIALS trial_result · 2026-06-05Clinical Trial Results: Feasibility & Acceptability of a Virtual Sister Circle Intervention for Black Women With Depressive Symptoms [NA]
A completed clinical trial evaluating the feasibility and acceptability of a virtual sister circle intervention for Black women with depress…
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CLINICAL_TRIALS trial_result · 2026-04-29Clinical Trial Results: Cognitive Fitness for Depression in Older Adults [NA]
Completed clinical trial results for a cognitive fitness intervention targeting depression in older adults; results posted.
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CLINICAL_TRIALS trial_result · 2026-04-29Clinical Trial Results: The Effects of Videogames on Depression Symptoms and Brain Dynamics [NA]
Completed clinical trial assessing the effects of videogames on depression symptoms and brain dynamics in adults with Major Depressive Disor…
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CLINICAL_TRIALS trial_result · 2026-04-28Clinical Trial Update: Pramipexole for Anhedonic Depression [Phase 3]
Phase 3 trial update for pramipexole in anhedonic depression has completed enrollment and status is completed.
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CLINICAL_TRIALS trial_result · 2026-04-28Clinical Trial Update: Long-term Efficacy of Pramipexole in Anhedonic Depression [Phase 3]
Phase 3 trial assessing long-term efficacy of pramipexole in anhedonic depression has completed.
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CLINICAL_TRIALS trial_result · 2026-04-28Clinical Trial Results: Decision Making Tool for Firearm Storage [NA]
The study report for a decision-making tool on firearm storage in adults with mild dementia and depression has been terminated, with results…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Comparing Acupuncture With Medication to Reduce Anxiety and Depression in China [Phase 4]
A Phase 4 clinical trial comparing acupuncture with medication to reduce anxiety and depression in China.
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Neuronavigation Guided iTBS With Personalized Target for Depression [Phase 2]
Phase 2 clinical trial update evaluating neuronavigation-guided intermittent theta-burst stimulation with personalized target for depression…
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: The Effect of Celecoxib on Neuroinflammation in MDD [Phase 4]
A Phase 4 clinical trial evaluating celecoxib for reducing neuroinflammation in patients with major depressive disorder has completed.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Psilocybin for Major Depressive Disorder (MDD) [Phase 3]
Phase 3 trial update for psilocybin in major depressive disorder. The study is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)
This clinical trial update outlines a pilot study using electrobulbogram (EBG), fMRI, and diffusion-weighted imaging to explore central brai…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder [Phase 1]
Clinical Trial Update describing a Phase 1 study evaluating neuropharmacologic imaging and biomarker assessments of response to acute- and r…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: MindfulCityU-- A Mindfulness Mobile Application for Promoting University Students' Mental Health [NA]
A clinical trial is evaluating a mindfulness mobile app, MindfulCityU, to improve mental health and reduce depressive symptoms among univers…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression [Phase 2]
A Phase 2 clinical trial evaluating the effectiveness of DT-101 in patients with Major Depressive Disorder is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
A prospective observational study examining how sociodemographic factors, blood-based biomarkers, and psychiatric symptoms relate across sev…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: [18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET [Phase 1]
A Phase 1 clinical trial update from NIMH evaluating the PET radiotracer [18F]PF-06445974 to image PDE4B in individuals with major depressiv…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Nebulized Ketamine for the Treatment of Major Depressive Disorder [Phase 3]
A Phase 3 clinical trial is evaluating nebulized ketamine for major depressive disorder and is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Mindfulness-Based fMRI Neurofeedback for Depression [NA]
Columbia University is conducting a trial to evaluate mindfulness-based fMRI neurofeedback as a treatment for depression in adolescence, wit…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders [Phase 2]
Clinical trial update for a Phase 2 study by the National Institute of Mental Health (NIMH) exploring neuro-cognitive correlates of pediatri…
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Sedation and Guided Education for Depression Study [NA]
Clinical trial update for a Sedation and Guided Education for Depression study focused on Major Depressive Disorder; the study status is NOT…