Lymphoblastic Lymphoma

• CLINICAL_TRIALS research · 2025-12-16
  Clinical Trial Update: Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment [Phase 3]

  Update on a Phase 3 clinical trial evaluating individualized, targeted, and intensified therapy for adults with newly diagnosed acute lympho…

• CLINICAL_TRIALS research · 2025-12-12
  Clinical Trial Update: To Observe the CD7-targeted CAR-T Therapy in the Treatment of MRD Positive T-ALL/LBL Post Allo-HSCT [Phase 1]

  A Phase 1 clinical trial is evaluating CD7-targeted CAR-T therapy for patients with MRD-positive T-cell acute lymphoblastic leukemia or lymp…

• CLINICAL_TRIALS research · 2025-12-02
  Clinical Trial Update: CD7-CAR-T Cells in Pediatric Relapsed/Refractory CD7+ T-ALL/LL [Phase 1, Phase 2]

  An ongoing Phase 1/2 pediatric trial evaluating CD7-targeted CAR-T cells for relapsed/refractory CD7-positive T-cell acute lymphoblastic leu…

• CLINICAL_TRIALS research · 2025-10-15
  Clinical Trial Update: Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant [Phase 2]

  Phase 2 clinical trial evaluating naive T cell depletion to prevent chronic graft-versus-host disease in children and young adults receiving…

• CLINICAL_TRIALS trial_result · 2025-09-30
  Clinical Trial Update: A Phase 1 Study of of Anti-CD7 Allogeneic CAR-T Cell Therapy (WU-CART-007) in Patients With Relapsed or Refractory T-ALL/LBL [Phase 1]

  This report summarizes the completion of a Phase 1 study of WU-CART-007, an allogeneic anti-CD7 CAR-T cell therapy, in patients with relapse…

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• EMA approval · 2025-09-17
  EMA Authorised: Besponsa (Inotuzumab ozogamicin) — Pfizer Europe MA EEIG

  The European Medicines Agency authorised Besponsa (inotuzumab ozogamicin) for precursor cell lymphoblastic leukemia-lymphoma under Pfizer Eu…

• CLINICAL_TRIALS research · 2025-09-16
  Clinical Trial Update: HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies [Phase 1, Phase 2]

  This clinical trial registration outlines a Phase 1/2 pediatric study of a multi-drug regimen (dasatinib, venetoclax, dexamethasone, cycloph…

• CLINICAL_TRIALS research · 2025-09-16
  Clinical Trial Update: HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies [Phase 1, Phase 2]

  Ongoing Phase 1/Phase 2 clinical trial evaluating trametinib with dexamethasone and chemotherapy in children with relapsed or refractory acu…

• CLINICAL_TRIALS research · 2025-09-16
  Clinical Trial Update: HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies [Phase 1, Phase 2]

  Clinical trial update for HEM-iSMART-C evaluating ruxolitinib, venetoclax, dexamethasone, cyclophosphamide, and cytarabine in pediatric pati…

• CLINICAL_TRIALS trial_result · 2025-09-16
  Clinical Trial Update: HEM-iSMART E: Capivasertib + Venetoclax + Dexamethasone in Pediatric Patients With Relapsed or Refractory Hematological Malignancies [Phase 1, Phase 2]

  This pediatric Phase 1/2 clinical trial evaluates capivasertib plus venetoclax and dexamethasone for relapsed or refractory hematologic mali…

• CLINICAL_TRIALS trial_result · 2025-08-11
  Clinical Trial Update: Tagraxofusp and Low-Intensity Chemotherapy for the Treatment of CD123 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma [Phase 1, Phase 2]

  Phase 1/2 trial evaluating tagraxofusp in combination with low-intensity chemotherapy for CD123-positive relapsed or refractory acute lympho…

• CLINICAL_TRIALS trial_result · 2025-06-17
  Clinical Trial Update: PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma [Phase 1, Phase 2]

  This clinical trial update summarizes the Phase 1/2 results of oral ixazomib in combination with chemotherapy for pediatric patients with re…

• CLINICAL_TRIALS research · 2025-05-23
  Clinical Trial Update: Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment

  An ongoing clinical trial is evaluating whether dexrazoxane hydrochloride affects biomarkers linked to cardiomyopathy and heart failure afte…

• CLINICAL_TRIALS other · 2025-04-29
  Clinical Trial Update: MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing [NA]

  Clinical trial update from the Medical College of Wisconsin describes a study using targeted antithymocyte globulin dosing to deplete alpha/…

• CLINICAL_TRIALS research · 2025-03-21
  Clinical Trial Update: International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma [Phase 3]

  An international Phase 3 clinical trial protocol assessing treatment for children and adolescents with lymphoblastic lymphoma; recruitment i…

• CLINICAL_TRIALS trial_result · 2025-03-07
  Clinical Trial Update: Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease [Phase 2]

  Phase 2 trial evaluating an umbilical cord blood transplant regimen with cyclophosphamide, fludarabine, and total-body irradiation for hemat…

• CLINICAL_TRIALS research · 2025-03-06
  Clinical Trial Update: Effectiveness and Safety of InO±DLI for Relapsed B-ALL/LBL After Allo-HSCT [Phase 2]

  Phase 2 clinical trial evaluating inotuzumab ozogamicin with or without donor lymphocyte infusion for relapsed B-lymphoblastic leukemia or l…

• CLINICAL_TRIALS research · 2025-03-06
  Clinical Trial Update: A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemia and Lymphoblastic Lymphoma in Children

  This ClinicalTrials.gov update describes a pediatric study at University Children's Hospital Basel evaluating how glucocorticoid therapy for…

• CLINICAL_TRIALS research · 2025-03-06
  Clinical Trial Update: Thiotepa, Cyclophosphamide, Clarithromycin and Cytarabine [Phase 1]

  A Phase 1 clinical trial evaluating a thiotepa, cyclophosphamide, clarithromycin, and cytarabine combination in adults with Burkitt lymphoma…

• CLINICAL_TRIALS withdrawal · 2025-02-03
  Clinical Trial Update: Expanded Access Program of Venetoclax and Navitoclax for Pediatric Patients with Relapsed or Refractory ALL or LL

  Expanded access program for venetoclax and navitoclax in pediatric relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphom…

• CLINICAL_TRIALS trial_result · 2024-12-06
  Clinical Trial Update: Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies [Phase 1]

  Phase 1 clinical trial studying tagraxofusp in pediatric patients with CD123-expressing hematologic malignancies is currently recruiting, sp…

• CLINICAL_TRIALS research · 2024-09-24
  Clinical Trial Update: BCL-2 Inhibitors Combined with the HyperCVAD Regimen for Newly Diagnosed T-lymphoblastic Leukemia/lymphoma. [Phase 2]

  A Phase 2 clinical trial evaluating BCL-2 inhibitors in combination with the HyperCVAD regimen for newly diagnosed T-cell lymphoblastic leuk…

• CLINICAL_TRIALS trial_result · 2024-08-16
  Clinical Trial Update: Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL) [Phase 1]

  Phase 1 trial results evaluate palbociclib in combination with chemotherapy for pediatric patients with relapsed acute lymphoblastic leukemi…

• CLINICAL_TRIALS research · 2024-08-14
  Clinical Trial Update: Glucose Intolerance and Diabetes Related to Treatment With Steroids and PEG- Asparaginase in Children and Adolescents With ALL and Lymphoma

  A clinical trial update evaluating glucose intolerance and diabetes related to steroid and PEG-asparaginase treatment in children and adoles…

• CLINICAL_TRIALS research · 2024-07-31
  Clinical Trial Update: Vitamin A and D Supplementation in Allogeneic HCT [Phase 2]

  Phase 2 clinical trial in allogeneic hematopoietic cell transplantation is evaluating vitamin A and vitamin D supplementation, currently rec…