Records containing: Low-grade Glioma
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CLINICAL_TRIALS study record update · 2026-04-24A Phase 2 Study of Trametinib for Patients With Pediatric Glioma or Plexiform Neurofibroma With Refractory Tumor and Activation of the MAPK/ERK Pathway.
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CLINICAL_TRIALS study record update · 2026-04-13PNOC021: A Phase I Trial Evaluating the Combination of Trametinib and Everolimus in Pediatric and Young Adult Patients With Recurrent Low-Grade Gliomas and High Grade Gliomas
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CLINICAL_TRIALS study record update · 2026-04-01PNOC042: A Phase 2, Multi-institutional Trial, Evaluating the Efficacy of Laser Interstitial Thermal Therapy (LITT) in Children, Adolescents and Young Adults With Recurrent or Progressive Low-grade Gliomas (LGG)
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CLINICAL_TRIALS study record update · 2026-03-12A Phase 2 De-escalation Study of Dabrafenib and Trametinib for Patients With BRAF V600 Mutant Low-Grade Gliomas
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CLINICAL_TRIALS study record update · 2026-03-02LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy
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CLINICAL_TRIALS study record update · 2026-03-02A Phase I, Open-label, Single-arm, Multicentre Study to Evaluate the Safety and Pharmacokinetics of Tovorafenib in Japanese Paediatric Participants With BRAF-altered Recurrent or Progressive Low-grade Glioma
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CLINICAL_TRIALS study record update · 2026-02-25\Multi-Center Phase I Study of Avutometinib (VS-6766), a RAF/MEK Clamp in Combination With Defactinib, a FAK Inhibitor, in Pediatric Patients With Refractory or Recurrent Solid Tumors Harboring Activating MAPK Pathway or NF2 Alterations
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CLINICAL_TRIALS study record update · 2026-02-19A Phase I Study of Tovorafenib/DAY101 (Formerly TAK-580, MLN2480) for Children With Low-Grade Gliomas and Other RAS/RAF/MEK/ERK Pathway Activated Tumors
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CLINICAL_TRIALS study record update · 2026-02-09A Phase 0 Clinical Trial to Evaluate Drug Concentrations and Pharmacodynamic Parameters of Niraparib in Tumor Tissue of Patients With Surgically Accessible Recurrent IDH 1/2 Gliomas
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CLINICAL_TRIALS study record update · 2026-01-27HiLoGlio Organoid Study: 'A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors'
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CLINICAL_TRIALS study record update · 2026-01-26Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas
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CLINICAL_TRIALS study record update · 2025-12-04Evaluation of 18F-Fluciclovine PET-MRI as a Biomarker of Response in Pediatric and Young Adult Patients With Low Grade Gliomas (LGG)
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CLINICAL_TRIALS study record update · 2025-11-21HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)
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CLINICAL_TRIALS study record update · 2025-06-17Ultrasound Imaging in Brain Tumour Surgery With the Use of SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue
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CLINICAL_TRIALS study record update · 2025-06-04An Open-label, Randomized, Multi-center Phase III Clinical Study: Aim to Evaluate the Efficacy and Safety of FCN-159 Monotherapy Versus the Treatment by Investigator's Choice in Patients With Pediatric Low-grade Glioma Harboring KIAA1549-BRAF Fusion or BRAF V600E Mutation
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CLINICAL_TRIALS study record update · 2025-05-15VICTORY: A Pilot Study to Investigate Safety and Efficacy of Weekly Combination of Intravenous Vinblastine With Oral Type II RAF Inhibitor Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas
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CLINICAL_TRIALS study record update · 2025-04-10FIREFLY-1: A Phase 2, Open-Label, Multicenter Study to Evaluate the Safety and Efficacy of the Oral Pan-RAF Inhibitor DAY101 in Pediatric Patients With RAF-Altered, Recurrent or Progressive Low-Grade Glioma and Advanced Solid Tumors
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CLINICAL_TRIALS study record update · 2025-03-21A Phase II Trial of Poly-ICLC for Progressive, Previously Treated Low-Grade Gliomas in Children and Young Adults With Neurofibromatosis Type 1
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CLINICAL_TRIALS study record update · 2024-11-12An Open-label, Non-randomized, Single Dose, Phase II Trial of FG001 (an Optical Imaging Agent) for Localization of Meningiomas or Presumed Low-Grade Gliomas Scheduled for Neurosurgery
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CLINICAL_TRIALS study record update · 2024-09-24Monitoring of Patients With Low-grade Gliomas Using Circulating miRNA
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CLINICAL_TRIALS study record update · 2024-08-12Expanded Access to the Oral Pan-RAF Inhibitor DAY101 in Pediatric Patients With RAF-Altered, Relapsed or Refractory Low-Grade Glioma
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CLINICAL_TRIALS study record update · 2024-07-05A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
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CLINICAL_TRIALS study record update · 2023-12-13Phase II Investigator-initiated Trial of Binimetinib in Patients With BRAF Fusion-positive Low-grade Glioma or Pancreatic Cancer (Perfume)
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CLINICAL_TRIALS study record update · 2023-09-26Evaluating the Impact of 2D Non-Navigated Intraoperative Ultrasound on Extent of Resection and Patients' Outcome in Glioma Surgery: A Retrospective Study
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CLINICAL_TRIALS study record update · 2023-08-18A Multi-institutional Observational Study of CEST Imaging in Low-grade Glioma