Langerhans Cell Histiocytosis
📧 Sign up to get email alerts when something new happens for Langerhans Cell Histiocytosis.
Sign up freeTop drugs studied for this disease
-
CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Adebrelimab Combined With Trametinib in the Treatment of Refractory Recurrent Langerhans Cell Histiocytosis in Children and Adolescents [Phase 1]
A Phase 1 clinical trial evaluating the combination of adebrelimab and trametinib for refractory recurrent Langerhans cell histiocytosis in …
-
CLINICAL_TRIALS research · 2025-01-24Clinical Trial Update: To Evaluate the Efficacy, Safety, and PK Characteristics of FCN-159 in Pediatric Patients With Refractory/Recurrent LCH [Phase 2]
This clinical trial update notes a Phase 2 study evaluating FCN-159 in pediatric patients with refractory or recurrent Langerhans cell histi…
-
CLINICAL_TRIALS research · 2025-01-15Clinical Trial Update: Denosumab for the Treatment of Adult LCH [Phase 2]
Clinical trial update noting completion of a Phase 2 study evaluating denosumab for adult Langerhans cell histiocytosis.
-
CLINICAL_TRIALS trial_result · 2024-09-04Clinical Trial Update: Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 Pediatric MATCH trial evaluating samotolisib in pediatric patients with relapsed or refractory tumors harboring TSC or PI3K/mTOR mut…
-
CLINICAL_TRIALS research · 2024-07-17Clinical Trial Update: Biomarkers for Diagnostic, Prognostic and of Response to Treatment in Adult Langerhans Cell Histiocytosis
This clinical trial update describes ongoing research into biomarkers for diagnosing, prognosticating, and assessing treatment response in a…
- Want full summaries, importance scores, and drug timelines? Upgrade to Plus or Pro.
-
CLINICAL_TRIALS trial_result · 2023-09-13Clinical Trial Update: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
This Phase 2 Pediatric MATCH trial evaluated vemurafenib in children with BRAF V600-mutant relapsed or refractory advanced solid tumors, non…
-
CLINICAL_TRIALS trial_result · 2023-08-08Clinical Trial Update: The Efficacy and Safety of HLX208 in Adult Langerhans Cell Histiocytosis (LCH) and Erdheim-Chester Disease (ECD) With BRAF V600E Mutation [Phase 2]
Phase 2 clinical trial evaluating HLX208 for adult Langerhans Cell Histiocytosis and Erdheim-Chester Disease with BRAF V600E mutation; curre…
-
CLINICAL_TRIALS trial_result · 2023-05-16Clinical Trial Update: Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 Pediatric MATCH trial evaluating Ulixertinib for MAPK-pathway-mutant tumors in children, including advanced solid tumors, Non-Hodgki…
-
CLINICAL_TRIALS trial_result · 2023-04-27Clinical Trial Update: Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
This Phase 2 pediatric MATCH trial update reports results for tazemetostat in patients with relapsed or refractory solid tumors, non-Hodgkin…
-
CLINICAL_TRIALS trial_result · 2023-03-16Clinical Trial Update: A Combination of Vemurafenib, Cytarabine and 2-chlorodeoxyadenosine in Children With LCH and BRAF V600E Mutation [Phase 2]
Phase 2 trial evaluating a combination of vemurafenib, cytarabine, and 2-chlorodeoxyadenosine in children with Langerhans Cell Histiocytosis…
-
CLINICAL_TRIALS trial_result · 2022-07-26Clinical Trial Update: A Prospective Study for the Treatment of Children With Newly Diagnosed LCH Using a Cytarabine Contained Protocol [Phase 3]
A Phase 3 prospective trial evaluating a cytarabine-containing protocol for newly diagnosed Langerhans Cell Histiocytosis in children, curre…
-
CLINICAL_TRIALS trial_result · 2022-03-17Clinical Trial Update: Central China Rosai-Dorfman Disease Registry [Phase 4]
A Phase 4 clinical trial update for Rosai-Dorfman Disease registry in Central China; status is currently unknown.
-
CLINICAL_TRIALS trial_result · 2022-02-16Clinical Trial Update: Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-related Disorders [Phase 2]
Phase 2 clinical trial update on clofarabine for recurrent or refractory Langerhans cell histiocytosis with results posted.
-
CLINICAL_TRIALS trial_result · 2021-06-08Clinical Trial Update: AraC for Newly Diagnosed Adult Langerhans Cell Histiocytosis [Phase 2]
Phase 2 trial update for AraC in newly diagnosed adult Langerhans Cell Histiocytosis.
-
CLINICAL_TRIALS trial_result · 2021-06-08Clinical Trial Update: Thalidomide, Cyclophosphamide and Dexamethasone for Recurrent/Refractory Adult Langerhans Cell Histiocytosis [Phase 2]
Phase 2 clinical trial evaluating thalidomide, cyclophosphamide, and dexamethasone for recurrent/refractory adult Langerhans Cell Histiocyto…
-
CLINICAL_TRIALS trial_result · 2020-09-09Clinical Trial Update: A Study to Test the Ability of and Safety of GSK2110183 in Treating Langerhans Cell Histiocytosis [Phase 2]
A Phase 2 trial evaluating the efficacy and safety of GSK2110183 for Langerhans Cell Histiocytosis has completed.
-
CLINICAL_TRIALS trial_result · 2020-01-09Clinical Trial Update: Treatment of Resistant Langerhans Cell Histiocytosis With ENBREL [Phase 2]
Phase 2 trial update exploring ENBREL (etanercept) for resistant Langerhans cell histiocytosis.
-
CLINICAL_TRIALS trial_result · 2018-09-12Clinical Trial Update: Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis [Phase 2]
Phase 2 trial updates for methotrexate and cytosine in adult Langerhans Cell Histiocytosis.
-
CLINICAL_TRIALS trial_result · 2017-04-14Clinical Trial Update: Stem Cell Transplant for Immunologic or Histiocytic Disorders [Phase 2]
Phase 2 trial update on stem cell transplantation for immunologic or histiocytic disorders, with completed status and results posted in 2017…
-
CLINICAL_TRIALS trial_result · 2015-11-03Clinical Trial Update: Reduced Intensity Hematopoietic Cell Transplantation for Patients With Resistant Langerhans Cell Histiocytosis [Phase 2]
Phase 2 trial update on reduced intensity hematopoietic cell transplantation for patients with resistant Langerhans cell histiocytosis has b…
-
CLINICAL_TRIALS withdrawal · 2015-08-25Clinical Trial Update: Clofarabine for Langerhans in Pedi [Phase 2]
A Phase 2 trial of Clofarabine for pediatric Langerhans cell histiocytosis has been withdrawn.
-
CLINICAL_TRIALS trial_result · 2015-05-04Clinical Trial Update: Study of Sequential Administration of Oral 6-Thioguanine After Methotrexate in Patients With LCH [Phase 2]
A Phase 2 trial evaluating sequential administration of oral 6-thioguanine after methotrexate in patients with Langerhans cell histiocytosis…
-
CLINICAL_TRIALS trial_result · 2014-06-06Clinical Trial Update: Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer
The clinical trial evaluating blood stem cell transplants in adults and children with various hematologic cancers, sponsored by Columbia Uni…
-
CLINICAL_TRIALS trial_result · 2014-04-28Clinical Trial Update: T-Cell Depletion and Stem Cell Transplant for Immune Deficiencies and Histiocytic Disorders [Phase 2, Phase 3]
Phase 2/3 clinical trial evaluating T-cell depletion and stem cell transplantation for immune deficiencies and histiocytic disorders has bee…
-
CLINICAL_TRIALS trial_result · 2014-03-17Clinical Trial Update: Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy [Phase 1]
A National Cancer Institute-sponsored Phase 1 trial evaluating sunitinib malate in HIV-positive cancer patients on antiretroviral therapy ha…