Infective Endocarditis
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Sign up freeTop drugs studied for this disease
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FDA approval · 2019-07-12FDA Approved: DAPTOMYCIN — Original Application (Accord Healthcare, Inc.)
FDA approved Accord Healthcare, Inc.'s original application for daptomycin (generic), authorizing a generic version of the antibiotic.
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FDA approval · 2019-06-26FDA Approved: DAPTOMYCIN — Original Application (BE Pharmaceuticals Inc.)
FDA approved BE Pharmaceuticals Inc.'s original application for daptomycin, enabling the generic version of this antibiotic.
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FDA approval · 2019-06-24FDA Approved: DAPTOMYCIN — Original Application (Accord Healthcare Inc.)
FDA approves the original application for Daptomycin (generic) from Accord Healthcare Inc., authorizing its commercialization as a generic a…
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CLINICAL_TRIALS trial_result · 2019-01-23Clinical Trial Update: Combining Opioid Addiction Treatment Services With CARe for Infectious Endocarditis [NA]
A completed clinical trial evaluating integrating opioid addiction treatment with CARe for infective endocarditis.
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CLINICAL_TRIALS trial_result · 2018-07-17Clinical Trial Update: The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery [Phase 4]
Phase 4 study evaluating whether perioperative sodium bicarbonate improves postoperative kidney function in patients with infective endocard…
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CLINICAL_TRIALS trial_result · 2018-07-06Clinical Trial Update: Detection of the Most Common Microorganism of Infective Endocarditis in Assiut University Hospital
The document reports a clinical trial update focused on identifying the most common microorganism responsible for infective endocarditis at …
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FDA approval · 2018-06-05FDA Approved: DAPTOMYCIN — Original Application (Mylan Institutional LLC)
FDA approved a generic daptomycin product from Mylan Institutional LLC via an Original Application. This approval provides a non-brand versi…
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CLINICAL_TRIALS trial_result · 2018-03-08Clinical Trial Update: Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis [Phase 4]
This document reports the completion of a Phase 4 clinical trial evaluating the combination of fosfomycin and imipenem for treating infectiv…
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CLINICAL_TRIALS trial_result · 2017-11-27Clinical Trial Update: Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis
This completed clinical trial evaluated systemic microvascular endothelial dysfunction in patients presenting with infective endocarditis.
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FDA approval · 2017-09-12FDA Approved: DAPTOMYCIN — Original Application (Sagent Pharmaceuticals)
FDA approval record for Daptomycin under an Original Application by Sagent Pharmaceuticals (NDA 208385). The entry documents FDA approval of…
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FDA label_change · 2016-12-21FDA Approved: DAPTOMYCIN — Supplemental Application (Hikma Pharmaceuticals USA Inc.)
FDA approved the supplemental application for daptomycin by Hikma Pharmaceuticals USA Inc., resulting in changes to the labeling and potenti…
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CLINICAL_TRIALS research · 2016-08-05Clinical Trial Update: Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis
The trial update discusses the potential impact of a standardized clinical care pathway on prognosis and therapeutic management for infectiv…
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FDA approval · 2016-06-15FDA Approved: DAPTOMYCIN — Original Application (Hikma Pharmaceuticals USA Inc.)
FDA approved the original application for daptomycin, a bacterial antibiotic, as a generic version manufactured by Hikma Pharmaceuticals USA…
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CLINICAL_TRIALS withdrawal · 2015-12-14Clinical Trial Update: Retrospective Review of Management of Infective Endocarditis
Withdrawn clinical trial update for a retrospective review of management of infective endocarditis.
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CLINICAL_TRIALS trial_result · 2015-08-24Clinical Trial Update: Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism [NA]
A completed clinical trial examining how endothelial activation and coagulation changes in infective endocarditis influence embolism risk.
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CLINICAL_TRIALS research · 2015-06-18Clinical Trial Update: Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis
This is a clinical trial update from the University of Aarhus on beta-lactam pharmacokinetics in patients with Infective Endocarditis; the s…
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CLINICAL_TRIALS trial_result · 2015-06-09Clinical Trial Update: Early Clinical, Laboratory and Microbiological Predictors of Treatment Outcomes in Infective Endocaridtis
The update reports on early clinical, laboratory, and microbiological factors that may predict treatment outcomes in infective endocarditis.
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CLINICAL_TRIALS other · 2015-05-28Clinical Trial Update: PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I
A pilot study update describing the use of PET CT imaging to evaluate suspected infection of cardiac implantable electronic devices (CIEDs) …
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CLINICAL_TRIALS trial_result · 2013-05-22Clinical Trial Update: Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) [Phase 4]
Phase 4 study evaluating Cubicin with and without combination therapy for Staphylococcus aureus infective endocarditis; study terminated wit…
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CLINICAL_TRIALS trial_result · 2012-09-07Clinical Trial Update: Early Surgery Versus Conventional Treatment in Infective Endocarditis [Phase 4]
This Phase 4 trial compared early surgery to conventional treatment for infective endocarditis, with results posted in 2012.
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CLINICAL_TRIALS trial_result · 2011-12-06Clinical Trial Update: Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia [Phase 2]
Phase 2 study investigating higher doses of daptomycin and vancomycin for MRSA bacteremia/endocarditis was terminated with results posted in…
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CLINICAL_TRIALS withdrawal · 2011-09-28Clinical Trial Update: Safety and Efficacy Study of CUBICIN (Daptomycin) Under Conditions of Actual Use
A study evaluating the safety and efficacy of Cubicin (daptomycin) under real-use conditions has been withdrawn.
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CLINICAL_TRIALS research · 2010-01-20Clinical Trial Update: How to Improve Diagnosis in Infective Endocarditis
This clinical trial update discusses efforts to improve the diagnosis of infective endocarditis and outlines the NCT00524212 study conducted…
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CLINICAL_TRIALS trial_result · 2009-02-12Clinical Trial Update: IMAGE-Endocarditis: Resonance Magnetic Imaging at the Acute Phase of Endocarditis [NA]
Clinical trial update noting the completion of the IMAGE-Endocarditis study, which evaluated magnetic resonance imaging during the acute pha…
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CLINICAL_TRIALS research · 2008-02-26Clinical Trial Update: Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) [Phase 4]
This document outlines the rationale, design, and methods for the ENDOVAL trial, a Phase 4 study evaluating early surgery in patients with i…