Hypercholesterolemia
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Comparing an Investigational Medication Versus an Approved Medication in Reducing Cholesterol Levels (0653-025) [Phase 3]
Phase 3 trial comparing an investigational cholesterol-lowering medication to an approved therapy in hypercholesterolemia; the study has com…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578) [Phase 3]
A Phase 3 trial comparing ezetimibe plus simvastatin versus simvastatin alone for progression of carotid artery atherosclerosis has complete…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Observational Study to Evaluate LDL-C Lowering Effect of Ezetimibe (0653-070) [Phase 3]
This update documents the completion of a Phase 3 observational study evaluating the LDL-C lowering effect of ezetimibe in individuals with …
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Cholesterol Lowering Level of MK0653A+Simvastatin in Patients With Hypercholesterolemia and Atherosclerotic or Coronary Vascular Disease (0653A-806)(COMPLETED) [Phase 3]
A completed Phase 3 trial evaluated MK0653A in combination with simvastatin for cholesterol lowering in patients with hypercholesterolemia a…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: TWICE (Ezetimibe Together With Any Statin Cholesterol Enhancement)(0653-060) [Phase 3]
Completed Phase 3 trial TWICE evaluated ezetimibe together with any statin for lowering cholesterol in hypercholesterolemia and hyperlipidem…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: A Multicenter Study to Evaluate the Cholesterol Lowering Effects of Two Marketed Products in Patients With Type 2 Diabetes Mellitus and Hypercholesterolemia (MK-0653A-077) [Phase 3]
Phase 3 multicenter trial completed to evaluate the cholesterol-lowering effects of two marketed products in patients with Type 2 diabetes m…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Study of an Approved Drug With a Statin (a Medication That Lowers Cholesterol Levels) as Compared to Statin Therapy Alone in Patients With High Cholesterol (0653-040) [Phase 3]
Phase 3 trial evaluating adding an approved lipid-lowering drug to statin therapy versus statin therapy alone in adults with hypercholestero…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808) [Phase 3]
Phase 3 trial status update for MK0653A in patients with hypercholesterolemia hospitalized for a possible heart problem; the study has compl…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Randomized Parallel Group Trial Of The Efficacy And Safety Of Ezetimibe With A Statin Versus Statin Dose Doubling In Patients With Persistent Primary Hypercholesterolemia (0653-152)(COMPLETED) [Phase 4]
A randomized Phase 4 trial comparing ezetimibe added to a statin versus doubling the statin dose in patients with persistent primary hyperch…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: To Evaluate the Lipid-Lowering Efficacy and Safety of Simvastatin 40 Mg Tablet In Patients With Hypercholesterolemia (0733-264) [Phase 4]
A Phase 4 clinical trial evaluating the lipid-lowering efficacy and safety of simvastatin 40 mg tablets in adults with hypercholesterolemia …
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Switching to Rosuvastatin Versus Adding Ezetimibe to Atorvastatin Versus Doubling the Dose of Atorvastatin in Patients With Hypercholesterolemia and Risk Factors (P03708) [Phase 4]
Phase 4 trial comparing switching to rosuvastatin, adding ezetimibe to atorvastatin, or doubling the dose of atorvastatin in patients with h…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Ezetimibe Plus Simvastatin Versus Simvastatin in Untreated Subjects With High Cholesterol (P03435) [Phase 4]
A Phase 4 trial comparing ezetimibe plus simvastatin versus simvastatin alone in untreated individuals with high cholesterol has completed.
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: MD Ezetimibe Cyclosporine Interaction (0653-057) [Phase 1]
Phase 1 trial update evaluating a potential pharmacokinetic interaction between ezetimibe and cyclosporine in the context of cholesterol man…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Comparison of Co-administration of Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Primary Hypercholesterolemia (P03476) [Phase 4]
A Phase 4 trial compared co-administration of ezetimibe with simvastatin versus simvastatin alone in primary hypercholesterolemia; the study…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Two Investigational Drugs in Patients With Mixed Hyperlipidemia (0653-036) [Phase 3]
Phase 3 trial evaluating two investigational drugs for mixed hyperlipidemia has completed.
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED) [Phase 3]
Phase 3 study P03757 comparing ezetimibe plus simvastatin versus ezetimibe or simvastatin alone in adults with primary hypercholesterolemia …
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Co-administration Study in Patients With Elevated Cholesterol and Coronary Heart Disease (0653-802)(COMPLETED) [Phase 3]
A Phase 3 co-administration study in patients with hypercholesterolemia and coronary artery disease has completed.
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Investigational Drug Study in Patients With Elevated Cholesterol and Coronary Heart Disease (0653-801) [Phase 3]
This clinical trial update reports completion of a Phase 3 investigational study in patients with hypercholesterolemia and coronary artery d…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089) [Phase 4]
The EASEGO Phase 4 trial evaluated doubling the dose of atorvastatin or simvastatin, or a drug called INEGY, in patients with hypercholester…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Effect of Ezetimibe Plus Simvastatin on Flow-Mediated Brachial Artery Vasoactivity in Subjects With Primary Hypercholesterolemia (Study P03336) [Phase 3]
A Phase 3 trial evaluating the effect of combining ezetimibe with simvastatin on flow-mediated brachial artery vasoreactivity in people with…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Ezetimibe Plus Simvastatin Versus Simvastatin Alone in African-American Subjects With Primary Hypercholesterolemia (P03377) [Phase 4]
Phase 4 trial comparing the addition of ezetimibe to simvastatin versus simvastatin alone in African-American adults with primary hyperchole…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: A Study to Evaluate Ezetimibe in Korean Patients With Primary Hypercholesterolemia (0653-042) [Phase 3]
A Phase 3 trial evaluating ezetimibe in Korean patients with primary hypercholesterolemia has completed.
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: A Study to Evaluate an Investigational Drug in Patients With Mixed Hyperlipidemia (0653A-071)(COMPLETED) [Phase 3]
A Phase 3 clinical trial evaluating an investigational drug (0653A-071) for mixed hyperlipidemia has completed; the study enrolled patients …
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Study to Evaluate the Cholesterol Lowering Effects of Two Marketed Drugs in Patients With Elevated Cholesterol Levels (0653A-058) [Phase 3]
An update on a Phase 3 clinical trial evaluating the cholesterol-lowering effects of two marketed drugs in adults with elevated cholesterol;…
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Co-administration Study in Patients With Elevated Cholesterol and Coronary Heart Disease (0653-803) [Phase 3]
A Phase 3 co-administration trial in patients with elevated cholesterol and coronary disease has completed.