Hypercholesterolemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2018-11-01Clinical Trial Update: A Study of MK-6213 Co-Administered With Atorvastatin in Participants With Hypercholesterolemia (MK-6213-006) [Phase 2]
Phase 2 trial evaluating MK-6213 with statin atorvastatin in hypercholesterolemia completed; results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-10-31Clinical Trial Update: Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression [Phase 4]
A Phase 4 randomized trial compared imaging-based therapy to risk-factor-based therapy for plaque regression in atherosclerosis and hypercho…
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FDA approval · 2018-10-26FDA Approved: EZETIMIBE — Original Application (Accord Healthcare Inc.)
FDA approved Accord Healthcare Inc.'s original ANDA for a generic ezetimibe product, authorizing its marketing as a cholesterol-lowering tre…
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CLINICAL_TRIALS trial_result · 2018-10-18Clinical Trial Update: Efficacy and Safety Study of HS-25 in Chinese Adults With Primary Hypercholesterolemia [Phase 3]
Phase 3 trial evaluating efficacy and safety of HS-25 in Chinese adults with primary hypercholesterolemia has completed.
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CLINICAL_TRIALS trial_result · 2018-10-18Clinical Trial Update: Efficacy and Safety of HS-25 or in Combination With Atorvastatin in Chinese Adults With Primary Hypercholesterolemia [Phase 3]
Phase 3 trial update evaluating HS-25 alone or in combination with atorvastatin in Chinese adults with primary hypercholesterolemia.
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CLINICAL_TRIALS trial_result · 2018-10-15Clinical Trial Update: Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients [Phase 4]
Phase 4 clinical trial evaluating novel biomarkers of acute kidney injury in post-operative patients was terminated.
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CLINICAL_TRIALS trial_result · 2018-10-09Clinical Trial Update: A Study of Evacetrapib (LY2484595) in Combination With Atorvastatin in Japanese Participants With Primary Hypercholesterolemia [Phase 3]
Phase 3 trial of Evacetrapib (LY2484595) with atorvastatin in Japanese participants with primary hypercholesterolemia was terminated; result…
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CLINICAL_TRIALS trial_result · 2018-10-09Clinical Trial Update: A Study of Evacetrapib (LY2484595) in Japanese Participants With Primary Hypercholesterolemia [Phase 3]
Phase 3 trial of evacetrapib in Japanese participants with primary hypercholesterolemia was terminated; results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-08-31Clinical Trial Update: Evaluation of Evolocumab (AMG 145) Efficacy in Diabetic Adults With Hypercholesterolemia/Mixed Dyslipidemia [Phase 3]
Phase 3 trial evaluating evolocumab in diabetic adults with hypercholesterolemia or mixed dyslipidemia has completed with results posted.
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CLINICAL_TRIALS trial_result · 2018-08-31Clinical Trial Update: Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-4 [Phase 3]
Phase 3 trial update assessing goal achievement with an anti-PCSK9 antibody in statin-intolerant subjects for hypercholesterolemia.
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CLINICAL_TRIALS trial_result · 2018-08-14Clinical Trial Update: Efficacy and Safety of Combination of Rosuvastatin and Ezetimibe in Patients With Primary Hypercholesterolemia [Phase 3]
Phase 3 trial assessing the efficacy and safety of rosuvastatin in combination with ezetimibe for primary hypercholesterolemia has completed…
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CLINICAL_TRIALS trial_result · 2018-07-27Clinical Trial Update: Study to Evaluate the Safety, PK, and Pharmacodynamics of LIB003 [Phase 1]
A Phase 1 study evaluating the safety, pharmacokinetics, and pharmacodynamics of LIB003 in Hypercholesterolemia has completed. The trial was…
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CLINICAL_TRIALS trial_result · 2018-07-24Clinical Trial Update: Open Label Study of Long Term Safety Evaluation of Alirocumab [Phase 3]
Open-label, long-term safety study of Alirocumab (Praluent) in adults with hypercholesterolemia. Phase 3 trial results were posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-07-23Clinical Trial Update: A Pharmacokinetic and Pharmacodynamic Study of PF-04950615 (RN316) in Subjects With Hypercholesterolemia [Phase 1]
Phase 1 pharmacokinetic and pharmacodynamic study of PF-04950615 (RN316) in subjects with hypercholesterolemia, with results posted.
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CLINICAL_TRIALS trial_result · 2018-07-05Clinical Trial Update: Effects of Two Herbal Dietary Supplements on Lipid Metabolism in Moderate Hypercholesterolemia and Hypertriglyceridemia [Phase 1, Phase 2]
Clinical trial update on two herbal dietary supplements evaluating lipid metabolism in moderate hypercholesterolemia and hypertriglyceridemi…
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CLINICAL_TRIALS trial_result · 2018-07-05Clinical Trial Update: Clinical Trial of Protein and Blood Pressure [NA]
A completed clinical trial update for a study investigating protein and blood pressure in hypertension and hypercholesterolemia; results pos…
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FDA approval · 2018-07-02FDA Approved: CHOLESTYRAMINE — Original Application (Zydus Pharmaceuticals (USA) Inc.)
FDA approved the original application for cholestyramine from Zydus Pharmaceuticals (USA) Inc., establishing a generic version of the bile a…
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CLINICAL_TRIALS trial_result · 2018-06-13Clinical Trial Update: A Clinical Trial to Compare the Efficacy and Safety of a Combination Therapy of Ezetimibe and Rosuvastatin Versus Monotherapy of Rosuvastatin in Hypercholesterolemia Patients (I-ROSETTE Study) [Phase 3]
A Phase 3 trial comparing the combination of ezetimibe and rosuvastatin versus rosuvastatin alone in hypercholesterolemia has completed.
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CLINICAL_TRIALS trial_result · 2018-06-08Clinical Trial Update: Low Fat Vegan or American Heart Association Diets & Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol [NA]
Clinical trial comparing low-fat vegan vs American Heart Association diets in obese children with elevated cholesterol; study completed with…
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CLINICAL_TRIALS trial_result · 2018-06-01Clinical Trial Update: Phytosterols, Ezetimibe, and Cholesterol Metabolism [EARLY_Phase 1]
An early Phase 1 trial update evaluating the interaction of phytosterols with ezetimibe on cholesterol metabolism. The study includes partic…
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CLINICAL_TRIALS trial_result · 2018-05-31Clinical Trial Update: A Trial to Evaluate the Efficacy of AB-Life Probiotic Product on LDL-Cholesterol Reduction in Moderate Hypercholesterolemia [NA]
A completed clinical trial evaluating the efficacy of AB-Life Probiotic Product on lowering LDL-cholesterol in adults with moderate hypercho…
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CLINICAL_TRIALS trial_result · 2018-05-17Clinical Trial Update: Efficacy and Safety of Alirocumab Versus Placebo on Top of Maximally Tolerated Lipid Lowering Therapy in Patients With Hypercholesterolemia Who Have Type 1 or Type 2 Diabetes and Are Treated With Insulin (ODYSSEY DM - Insulin) [Phase 3]
Phase 3 trial update showing the efficacy and safety of alirocumab versus placebo on top of maximally tolerated lipid-lowering therapy in ad…
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FDA approval · 2018-05-16FDA Approved: COLESEVELAM HYDROCHLORIDE — Original Application (Amneal Pharmaceuticals of New York LLC)
FDA approved a generic version of Colesevelam hydrochloride from Amneal Pharmaceuticals of New York LLC for lowering elevated LDL cholestero…
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CLINICAL_TRIALS trial_result · 2018-05-11Clinical Trial Update: The Effect of CBT- Based Weight Loss Program on Obesity [NA]
This document reports the completed status of a clinical trial evaluating a cognitive-behavioral therapy-based weight loss program for obesi…
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CLINICAL_TRIALS trial_result · 2018-05-07Clinical Trial Update: Efficacy and Safety of Alirocumab in Patients With Hypercholesterolemia Not Adequately Controlled With Non-statin Lipid Modifying Therapy or the Lowest Strength of Statin [Phase 3]
Phase 3 trial results show the efficacy and safety of alirocumab in patients with hypercholesterolemia not adequately controlled with non-st…