Hyperalgesia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-06-04Clinical Trial Results: Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia [Phase 2]
Phase 2 trial investigating ultra-low dose naloxone to mitigate remifentanil-induced hyperalgesia; study terminated with results posted.
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CLINICAL_TRIALS trial_result · 2025-09-11Clinical Trial Update: Hyperalgesia and Pain [Phase 1]
Phase 1 clinical trial update focusing on hyperalgesia and pain has completed.
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CLINICAL_TRIALS trial_result · 2024-11-05Clinical Trial Update: Preventing Pain After Heart Surgery [Phase 4]
Phase 4 clinical trial update indicating completion of a study on preventing postoperative pain after heart surgery.
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting [Phase 4]
Phase 4 clinical trial update evaluating hyperalgesia, persistent pain, and fentanyl dosing in on-pump coronary artery bypass grafting.
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CLINICAL_TRIALS trial_result · 2024-05-21Clinical Trial Update: Evaluation of a Patient-Centred, Multidisciplinary Opioid Tapering Program for Individuals With Chronic Non-Cancer Pain on Long Term Opioid Therapy [NA]
Completed clinical trial evaluating a patient-centered, multidisciplinary opioid tapering program for individuals with chronic noncancer pai…
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CLINICAL_TRIALS trial_result · 2024-03-08Clinical Trial Update: Safety and Efficacy Evaluation of S (+) - Ketamine in Children [Phase 4]
A Phase 4 clinical trial assessing safety and efficacy of S(+)-ketamine in children for acute postoperative analgesia and related outcomes i…
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CLINICAL_TRIALS trial_result · 2024-02-22Clinical Trial Update: Effect of High-dose Naloxone Following Third Molar Extraction [Phase 2]
Phase 2 clinical trial evaluating high-dose naloxone after third molar extraction; completed study with healthy subjects and hyperalgesia in…
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CLINICAL_TRIALS trial_result · 2024-02-22Clinical Trial Update: Effect of High-dose Naloxone Infusion on Pain and Hyperalgesia in Patients Following Groin-Hernia Repair. [Phase 2]
Phase 2 trial studying high-dose naloxone infusion for pain and hyperalgesia after groin-hernia repair; completed.
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CLINICAL_TRIALS trial_result · 2021-08-03Clinical Trial Update: Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia [NA]
A completed clinical trial evaluated the combination of dexmedetomidine with low-dose nalmefene for preventing remifentanil-induced postoper…
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CLINICAL_TRIALS trial_result · 2019-06-21Clinical Trial Update: The Effect of Hyperbaric Oxygen Therapy on Inflammatory Parameters Induced by a Heat Injury Model [Phase 2]
Phase 2 trial updating on the effects of hyperbaric oxygen therapy on inflammatory parameters in a heat injury model.
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CLINICAL_TRIALS trial_result · 2018-12-31Clinical Trial Update: Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia [Phase 4]
Phase 4 trial evaluating acetazolamide to prevent remifentanil-induced hyperalgesia has completed.
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CLINICAL_TRIALS trial_result · 2017-08-07Clinical Trial Update: A Study Of GSK189254 And Duloxetine In The Electrical Hyperalgesia Model Of Healthy Volunteers [Phase 1]
A Phase 1 study evaluating GSK189254 and duloxetine in an electrical hyperalgesia model in healthy volunteers has completed.
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CLINICAL_TRIALS trial_result · 2016-06-21Clinical Trial Update: IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery [Phase 4]
Phase 4 trial results on intravenous acetaminophen as an adjunct analgesic in cardiac surgery, evaluating effects on acute pain and hyperalg…
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CLINICAL_TRIALS trial_result · 2016-06-06Clinical Trial Update: Preoperative Intraarticular Injection of Methylprednisolone in Patients Scheduled for Total Knee-arthroplasty [Phase 2]
Phase 2 clinical trial evaluating preoperative intraarticular methylprednisolone in patients scheduled for total knee arthroplasty has compl…
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CLINICAL_TRIALS trial_result · 2016-04-29Clinical Trial Update: Fenobam on Heat/Capsaicin Induced Hyperalgesia in Healthy Volunteers [Phase 1]
Phase 1 study evaluating fenobam for heat/capsaicin-induced hyperalgesia and allodynia in healthy volunteers has completed.
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CLINICAL_TRIALS trial_result · 2016-04-01Clinical Trial Update: Dextromethorphan Effect on Central Sensitization to Pain in Healthy Volunteers [Phase 1]
Phase 1 trial evaluating the effect of dextromethorphan on central sensitization to pain in healthy volunteers has completed.
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CLINICAL_TRIALS trial_result · 2015-11-18Clinical Trial Update: Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen [NA]
A completed clinical trial evaluated whether intravenous ibuprofen can prevent remifentanil-induced postoperative hyperalgesia.
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CLINICAL_TRIALS trial_result · 2014-11-10Clinical Trial Update: Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia [Phase 3]
Phase 3 clinical trial evaluating whether ketamine influences remifentanil-induced hyperalgesia; study completed with results posted in 2014…
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CLINICAL_TRIALS trial_result · 2014-10-29Clinical Trial Update: Opioid-induced Hyperalgesia After Remifentanil Infusion [Phase 4]
Phase 4 clinical trial update evaluating opioid-induced hyperalgesia after remifentanil infusion. The study status is completed.
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CLINICAL_TRIALS trial_result · 2014-09-17Clinical Trial Update: MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI
This completion update describes a completed clinical trial evaluating MR spectroscopy as a diagnostic tool and outcome measure in pain asso…
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CLINICAL_TRIALS trial_result · 2014-02-25Clinical Trial Update: Effect of High Dose Naloxone on Secondary Hyperalgesia [Phase 1]
A Phase 1 trial evaluating whether high-dose naloxone can affect secondary hyperalgesia has completed.
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CLINICAL_TRIALS trial_result · 2013-12-13Clinical Trial Update: Hypoalgesic Effects Neural Mobilization Techniques [EARLY_Phase 1]
This document provides an update on an early Phase 1 clinical trial evaluating hypoalgesic effects of neural mobilization techniques in indi…
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CLINICAL_TRIALS trial_result · 2013-10-14Clinical Trial Update: Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil [NA]
A completed clinical trial evaluating the development of opioid-induced hyperalgesia after exposure to alfentanil; results posted in 2013.
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CLINICAL_TRIALS trial_result · 2012-06-20Clinical Trial Update: Local Anesthetic Infiltration to Prevent Postoperative Pain After Lumbar Surgery [Phase 3]
The document reports the completion of a Phase 3 trial evaluating local anesthetic infiltration to prevent postoperative pain after lumbar s…
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CLINICAL_TRIALS trial_result · 2011-07-01Clinical Trial Update: Modulation of Remifentanil-induced Postinfusion Hyperalgesia [Phase 4]
This clinical trial update reports on a Phase 4 study investigating strategies to modulate remifentanil-induced postinfusion hyperalgesia.