Hepatocellular Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Impact of Splenectomy on the Efficacy of Targeted Therapy and Immunotherapy in Unresectable HCC Patients With Cirrhotic Portal Hypertension
This clinical trial update notes a study evaluating whether splenectomy influences the effectiveness of targeted therapy and immunotherapy i…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Acceptance and Commitment Therapy (ACT-HBC) for the Improvement of Cancer Distress in Patients With Hepatobiliary Cancers [NA]
Mayo Clinic is recruiting for a study of Acceptance and Commitment Therapy for reducing cancer-related distress in patients with malignant h…
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CLINICAL_TRIALS trial_result · 2025-08-14Clinical Trial Update: Phase II Study of Concurrent Lenvatinib and Radiotherapy for Advanced HCC [Phase 2]
This update reports the completion of a Phase II study evaluating concurrent lenvatinib and radiotherapy for advanced hepatocellular carcino…
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CLINICAL_TRIALS trial_result · 2025-08-14Clinical Trial Update: MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005) [Phase 2]
Merck completed a Phase 2 trial (MK-7684A-005) evaluating MK-7684A with or without other anticancer therapies in selected solid tumors.
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC) [Phase 2]
A Phase 2 clinical trial evaluating adverse events and changes in disease activity when Livmoniplimab is combined with Budigalimab in adults…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: Autologous Neoantigen-Specific T-Cell Therapy for Advanced Hepatocellular Carcinoma [Phase 1, Phase 2]
Clinical trial update on an autologous neoantigen-specific T-cell therapy for advanced hepatocellular carcinoma; the Phase 1/2 study is curr…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: Evaluation of SIRT Followed by Immunotherapy for Treatment of Hepatocellular Carcinoma With Portal Vein Thrombosis [Phase 2]
Phase 2 clinical trial evaluating selective internal radiation therapy (SIRT) followed by immunotherapy for non-resectable hepatocellular ca…
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CLINICAL_TRIALS trial_result · 2025-08-14Clinical Trial Update: Locoregional Therapy Combined With Bevacizumab and PD1/L1 Inhibitor in Advanced Hepatocellular Carcinoma
A study evaluating locoregional therapy combined with Bevacizumab and a PD-1/PD-L1 inhibitor in advanced hepatocellular carcinoma is current…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: TACE Combined With Lenvatinib and PD-1 Inhibitor for Ruptured Hepatocellular Carcinoma [NA]
A clinical trial update indicates a study evaluating transarterial chemoembolization (TACE) combined with lenvatinib and a PD-1 inhibitor fo…
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CLINICAL_TRIALS trial_result · 2025-08-13Clinical Trial Update: Safety and Efficacy of Coformulated Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib (E7080/MK-7902) in Advanced Hepatocellular Carcinoma (MK-1308A-004) [Phase 2]
Phase 2 trial assessing the safety and efficacy of a coformulated pembrolizumab/quavonlimab plus lenvatinib in patients with advanced hepato…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: A Clinical Study Evaluating HAIC Combined With Iparomlimab and Tuvonralimab Injection Plus Bevacizumab in Patients With Initially Potentially Resectable Hepatocellular Carcinoma (ITBHaic Study) [Phase 2]
A Phase 2 trial evaluating a combination of hepatic arterial infusion chemotherapy with iparomlimab, tuvonralimab, and bevacizumab for initi…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: Post-Radical Treatment Antiviral Strategies in HBV-Related Liver Cancer: Impact on Tumor Prognosis
A clinical trial update describing post-radical treatment antiviral strategies for HBV-related hepatocellular carcinoma and their potential …
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: CT-guided Localization for Micro Hepatocellular Carcinoma Before Surgical Resection [NA]
This clinical trial is evaluating CT-guided localization for micro hepatocellular carcinoma before surgical resection. The study is currentl…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: ProspEXPO : Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome [NA]
A clinical trial called ProspEXPO investigates associations between hepatocellular carcinoma and chemical and psychosocial environmental exp…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: Enhanced Outpatient Symptom Management to Reduce Acute Care Visits Due to Chemotherapy-Related Adverse Events [NA]
A clinical trial at MD Anderson Cancer Center is evaluating enhanced outpatient symptom management to reduce acute care visits caused by che…
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CLINICAL_TRIALS withdrawal · 2025-08-12Clinical Trial Update: A Clinical Study of TQB2618 Injection Combined With Penpulimab Injection and Anlotinib Hydrochloride Capsules for First-line Treatment of Advanced Hepatocellular Carcinoma (HCC). [Phase 1]
Phase 1 trial evaluating TQB2618 with Penpulimab and Anlotinib for first-line advanced hepatocellular carcinoma has been terminated.
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: A Prospective Observational Cohort Study on Dynamic CD8+ T-cell Profiling and Multi-omics Biomarkers for Predicting Conversion Therapy Response in Unresectable Hepatocellular Carcinoma
This clinical trial update describes a prospective observational cohort in unresectable hepatocellular carcinoma to profile dynamic CD8+ T c…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: AHCC® as Immune Modulator in Cancer Patients Treated With Immunotherapy [NA]
Clinical trial update assessing AHCC as an immune modulator in cancer patients treated with immunotherapy; the study status is not yet recru…
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: A Single-center, Single-arm, Phase II Clinical Study of Iparomlimab and Tuvonralimab Injection Combined With Regorafenib in the Treatment of Advanced Second-line or Above Hepatocellular Carcinoma [NA]
A single-center, single-arm Phase II study evaluating a combination of Iparomlimab and Tuvonralimab with Regorafenib for advanced second-lin…
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: A Study of Valemetostat Tosylate (DS-3201b) With Atezolizumab and Bevacizumab in HCC [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating valemetostat tosylate (DS-3201b) in combination with atezolizumab and bevacizumab for hepatocellular car…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: To Test Whether Time-restricted Eating Coupled With a Healthy Diet is Beneficial in Liver Cancer Patients [NA]
This ClinicalTrials.gov update indicates a study evaluating whether time-restricted eating plus a healthy diet benefits adults with liver ca…
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: Development and Prospective Validation of a Heterogeneous Treatment Effect-Based Decision Model for Transarterial Chemoembolization Combined With or Without Atezolizumab Plus Bevacizumab in Unresectable Hepatocellular Carcinoma [NA]
This clinical trial update describes the development and prospective validation of a heterogeneous treatment effect-based decision model for…
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Bleeding in Laparoscopic Liver Surgery [NA]
A terminated clinical trial (NCT04609410) investigated intraoperative bleeding during laparoscopic liver surgery in hepatic cancer and relat…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA) [Phase 2]
A Phase 2 clinical trial (FLORA) is evaluating fecal microbiota transfer to overcome resistance to atezolizumab/bevacizumab in hepatocellula…
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CLINICAL_TRIALS research · 2025-08-05Clinical Trial Update: Predictors of HCC in Post-HCV Cirrhotic Patients After SVR
This clinical trial aims to identify predictors of hepatocellular carcinoma in patients with HCV-related cirrhosis who achieved sustained vi…