Hepatocellular Carcinoma

• CLINICAL_TRIALS trial_result · 2025-08-28
  Clinical Trial Update: 18F-DCFPyL PET/CT in Hepatocellular Carcinoma [Phase 2]

  Phase 2 trial evaluating the PSMA PET imaging agent 18F-DCFPyL for hepatocellular carcinoma was terminated; results have been posted.

• CLINICAL_TRIALS trial_result · 2025-08-27
  Clinical Trial Update: Dietary Intervention and Gut Microbiota in Hepatocellular Carcinoma (HCC) [NA]

  This entry reports on a dietary intervention and gut microbiota study in hepatocellular carcinoma, and the trial has completed.

• CLINICAL_TRIALS trial_result · 2025-08-26
  Clinical Trial Update: Holmium-166 Transarterial Radioembolization in Unresectable, Early Stage Hepatocellular Carcinoma. [NA]

  A clinical trial evaluating Holmium-166 transarterial radioembolization for unresectable, early-stage hepatocellular carcinoma was terminate…

• CLINICAL_TRIALS trial_result · 2025-08-21
  Clinical Trial Update: A Phase I Clinical Study of Intratumoral Injection Oncolytic Vaccinia Virus GC001 in Patient With Advanced Solid Tumors [Phase 1]

  A Phase I trial evaluating intratumoral injection of GC001, an oncolytic vaccinia virus, in patients with advanced solid tumors is currently…

• CLINICAL_TRIALS trial_result · 2025-08-20
  Clinical Trial Update: Perflutren Protein-Type A Microspheres and Contrast-Enhanced Ultrasound in Improving Response to Radioembolization Therapy in Patients With Liver Cancer [Phase 2]

  Phase 2 clinical trial evaluating whether Definity (perflutren protein-type A microspheres) contrast-enhanced ultrasound improves response t…

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• CLINICAL_TRIALS trial_result · 2025-08-17
  Clinical Trial Update: CTLA-4 /PD-L1 Blockade Following Transarterial Chemoembolization (DEB-TACE) in Patients With Intermediate Stage of HCC (Hepatocellular Carcinoma) Using Durvalumab and Tremelimumab [Phase 2]

  A Phase 2 trial at Johns Hopkins evaluated a combination of CTLA-4 and PD-L1 blockade (tremelimumab and durvalumab) after DEB-TACE in interm…

• CLINICAL_TRIALS trial_result · 2025-08-14
  Clinical Trial Update: Phase II Study of Concurrent Lenvatinib and Radiotherapy for Advanced HCC [Phase 2]

  This update reports the completion of a Phase II study evaluating concurrent lenvatinib and radiotherapy for advanced hepatocellular carcino…

• CLINICAL_TRIALS trial_result · 2025-08-14
  Clinical Trial Update: MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005) [Phase 2]

  Merck completed a Phase 2 trial (MK-7684A-005) evaluating MK-7684A with or without other anticancer therapies in selected solid tumors.

• CLINICAL_TRIALS trial_result · 2025-08-14
  Clinical Trial Update: Locoregional Therapy Combined With Bevacizumab and PD1/L1 Inhibitor in Advanced Hepatocellular Carcinoma

  A study evaluating locoregional therapy combined with Bevacizumab and a PD-1/PD-L1 inhibitor in advanced hepatocellular carcinoma is current…

• CLINICAL_TRIALS trial_result · 2025-08-13
  Clinical Trial Update: Safety and Efficacy of Coformulated Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib (E7080/MK-7902) in Advanced Hepatocellular Carcinoma (MK-1308A-004) [Phase 2]

  Phase 2 trial assessing the safety and efficacy of a coformulated pembrolizumab/quavonlimab plus lenvatinib in patients with advanced hepato…

• CLINICAL_TRIALS trial_result · 2025-08-07
  Clinical Trial Update: Bleeding in Laparoscopic Liver Surgery [NA]

  A terminated clinical trial (NCT04609410) investigated intraoperative bleeding during laparoscopic liver surgery in hepatic cancer and relat…

• CLINICAL_TRIALS trial_result · 2025-08-01
  Clinical Trial Update: Evaluating the Potential Usefulness of 18F-AlF-FAPI PET/CT in Patients With Gastrointestinal Tumors and Compared With 18F-FDG PET/CT [NA]

  Completed clinical trial comparing 18F-AlF-FAPI PET/CT with 18F-FDG PET/CT in patients with gastric cancer, pancreatic cancer, and hepatocel…

• CLINICAL_TRIALS trial_result · 2025-07-31
  Clinical Trial Update: Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer [NA]

  This completed clinical trial compared different anesthetic techniques to assess their impact on intraoperative and postoperative pain and c…

• CLINICAL_TRIALS trial_result · 2025-07-28
  Clinical Trial Update: CT Imaging for Guiding PA-TACE for HCC

  The clinical trial evaluating CT imaging to guide PA-TACE for hepatocellular carcinoma has completed.

• CLINICAL_TRIALS trial_result · 2025-07-25
  Clinical Trial Update: Study of Pembrolizumab and Radiotherapy in Liver Cancer [Phase 2]

  Phase 2 study evaluating pembrolizumab with radiotherapy for hepatocellular carcinoma was terminated, with results posted on 2025-07-25.

• CLINICAL_TRIALS trial_result · 2025-07-23
  Clinical Trial Update: Non-Interventional Registry Study to Evaluate the Effectiveness of TheraSphere® in the Treatment of Hepatocellular Carcinoma (HCC)

  A completed non-interventional registry study evaluating the effectiveness of TheraSphere for hepatocellular carcinoma.

• CLINICAL_TRIALS trial_result · 2025-07-23
  Clinical Trial Update: Pembrolizumab and Lenvatinib in Patients With Advanced HCC Who Are Refractory to Atezolizumab and Bevacizumab/ IO-based Therapy [Phase 2]

  A Phase 2 trial evaluating pembrolizumab in combination with lenvatinib for advanced hepatocellular carcinoma refractory to IO-based therapy…

• CLINICAL_TRIALS trial_result · 2025-07-22
  Clinical Trial Update: WGc-0201 Plus Tislelizumab in HCC With High Risk of Recurrence and Metastasis After Radical Therapy [Phase 1]

  A Phase 1 clinical trial update evaluating WGc-0201 in combination with tislelizumab for hepatocellular carcinoma at high risk of recurrence…

• CLINICAL_TRIALS trial_result · 2025-07-22
  Clinical Trial Update: Adjuvant Sintilimab Plus Lenvatinib for HCC Characterized With VETC Following Liver Resection [NA]

  This trial update describes evaluating adjuvant therapy with sintilimab plus lenvatinib for hepatocellular carcinoma with VETC after liver r…

• CLINICAL_TRIALS trial_result · 2025-07-22
  Clinical Trial Update: Application of mRNA Vaccine in Liver Transplantation for Hepatocellular Carcinoma [Phase 1]

  Phase 1 clinical trial evaluating an mRNA vaccine in liver transplantation for hepatocellular carcinoma is currently recruiting.

• CLINICAL_TRIALS trial_result · 2025-07-20
  Clinical Trial Update: TACE Plus Bevacizumab for Hepatocellular Carcinoma With Portal Vein Invasion [NA]

  A completed clinical trial investigated transarterial chemoembolization (TACE) plus bevacizumab for hepatocellular carcinoma with portal vei…

• CLINICAL_TRIALS trial_result · 2025-07-15
  Clinical Trial Update: Pembrolizumab (MK-3475) in Hepatocellular Carcinoma [Phase 2]

  Phase 2 study of pembrolizumab (MK-3475) in hepatocellular carcinoma (BCLC stages B and C) has completed with results posted.

• CLINICAL_TRIALS trial_result · 2025-07-15
  Clinical Trial Update: RCT of Screening Strategies Among Patients at High Risk for Developing HCC in a Safety-net Health System [NA]

  This completed randomized controlled trial evaluated screening strategies for hepatocellular carcinoma among high-risk patients in a safety-…

• CLINICAL_TRIALS trial_result · 2025-07-14
  Clinical Trial Update: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors [Phase 1]

  This Phase 1 trial reports on the safety, tolerability, pharmacokinetics, and pharmacodynamics of INCB099280 in participants with advanced s…

• CLINICAL_TRIALS trial_result · 2025-07-10
  Clinical Trial Update: 89Zr-girentuximab for PET Imaging of CAIX Positive Solid Tumors [Phase 2]

  Telix's phase 2 trial of the CAIX-targeting PET tracer 89Zr-girentuximab in CAIX-positive solid tumors was terminated.